| Title: |
Long-Term Risk of Stroke After Transient Ischemic Attack or Minor Stroke:A Systematic Review and Meta-Analysis |
| Authors: |
Khan,Faizan; Yogendrakumar,Vignan; Lun,Ronda; Ganesh,Aravind; Barber,Philip A; Lioutas,Vasileios-Arsenios; Vinding,Naja Emborg; Algra, Ale; Weimar,Christian; Ögren,Joachim; Edwards,Jodi D; Swartz,Richard H; Ois,Angel; Giralt-Steinhauer,Eva; Khanevski,Andrej Netland; Leng,Xinyi; Tian,Xuan; Leung,Thomas W; Park,Hong-Kyun; Bae,Hee-Joon; Kamouchi,Masahiro; Ago,Tetsuro; Verburgt,Esmee; Verhoeven,Jamie; de Leeuw,Frank-Erik; Berghout,Bernhard P; Ikram,M Kamran; Kostev,Karel; Whiteley,William; Uehara,Toshiyuki; Minematsu,Kazuo; Ildstad,Fredrik; Fandler-Höfler,Simon; Aarnio,Karoliina; von Sarnowski,Bettina; Foschi,Matteo; Jing,Jing; Baik,Minyoul; Kim,Young Dae; Spampinato,Michele Domenico; Hasegawa,Yasuhiro; Perera,Kanjana; Purroy,Francisco; Dutta,Dipankar; Yang,Xiaoli; Lippert,Julian; Myers,Laura; Bravata,Dawn M; Santos,Monica; Coveney,Sarah; Writing Committee for the PERSIST Collaborators; Cardiovasculaire Epi Team 5 |
| Publication Year: |
2025 |
| Subject Terms: |
Taverne; Journal Article |
| Description: |
IMPORTANCE: After a transient ischemic attack (TIA) or minor stroke, the long-term risk of stroke is not well-known. OBJECTIVE: To determine the annual incidence rates and cumulative incidences of stroke up to 10 years after TIA or minor stroke. DATA SOURCES: MEDLINE, Embase, and Web of Science were searched from inception through June 26, 2024. STUDY SELECTION: Prospective or retrospective cohort studies reporting stroke risk during a minimum follow-up of 1 year in patients with TIA or minor stroke. DATA EXTRACTION AND SYNTHESIS: Two reviewers independently performed data extraction and assessed study quality. Unpublished aggregate-level data on number of events and person-years during discrete follow-up intervals were obtained directly from the authors of the included studies to calculate incidence rates in individual studies. Data across studies were pooled using random-effects meta-analysis. MAIN OUTCOMES AND MEASURES: The primary outcome was any stroke. Study-level characteristics were investigated as potential sources of variability in stroke rates across studies. RESULTS: The analysis involved 171 068 patients (median age, 69 years [IQR, 65-71]; median proportion of male patients, 57% [IQR, 52%-60%]) from 38 included studies. The pooled rate of stroke per 100 person-years was 5.94 events (95% CI, 5.18-6.76; 38 studies; I2 = 97%) in the first year, 1.80 events (95% CI, 1.58-2.04; 25 studies; I2 = 90%) annually in the second through fifth years, and 1.72 events (95% CI, 1.31-2.18; 12 studies; I2 = 84%) annually in the sixth through tenth years. The 5- and 10-year cumulative incidence of stroke was 12.5% (95% CI, 11.0%-14.1%) and 19.8% (95% CI, 16.7%-23.1%), respectively. Stroke rates were higher in studies conducted in North America (rate ratio [RR], 1.43 [95% CI, 1.36-1.50]) and Asia (RR, 1.62 [95% CI, 1.52-1.73]), compared with Europe, in cohorts recruited in or after 2007 (RR, 1.42 [95% CI, 1.23-1.64]), and in studies that used active vs passive outcome ascertainment methods (RR, 1.11 [95% CI, ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0098-7484 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/465650 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/465650 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.F82DE107 |
| Database: |
BASE |