| Title: |
WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene |
| Authors: |
Nersisyan, Lilit; Nikoghosyan, Maria; Francioli, Laurent, C; Menelaou, Androniki; Pulit, Sara, L; Elbers, Clara, C; Kloosterman, Wigard, P; van Setten, Jessica; Nijman, Isaäc, J; Renkens, Ivo; de Bakker, Paul, I W; van Dijk, Freerk; Neerincx, Pieter, B T; Deelen, Patrick; Kanterakis, Alexandros; Dijkstra, Martijn; Byelas, Heorhiy; van der Velde, K, Joeri; Platteel, Mathieu; Swertz, Morris, A; Wijmenga, Cisca; Palamara, Pier, Francesco; Pe’er, Itsik; Ye, Kai; Lameijer, Eric-Wubbo; Moed, Matthijs, H; Beekman, Marian; de Craen, Anton, J M; Suchiman, H, Eka D; Slagboom, P, Eline; Guryev, Victor; Abdellaoui, Abdel; Jan Hottenga, Jouke; Kattenberg, Mathijs; Willemsen, Gonneke; Boomsma, Dorret, I; van Leeuwen, Elisabeth, M; Karssen, Lennart, C; Amin, Najaf; Rivadeneira, Fernando; Isaacs, Aaron; Hofman, Albert; Uitterlinden, André, G; van Duijn, Cornelia, M; van Oven, Mannis; Kayser, Manfred; Vermaat, Martijn; Laros, Jeroen, F J; den Dunnen, Johan, T; van Enckevort, David; Mei, Hailiang; Li, Mingkun; Stoneking, Mark; van Schaik, Barbera, D C; Bot, Jan; Marschall, Tobias; Schönhuth, Alexander; Hehir-Kwa, Jayne, Y; Handsaker, Robert, E; Polak, Paz; Sohail, Mashaal; Vuzman, Dana; Estrada, Karol; Mccarroll, Steven, A; Sunyaev, Shamil, R; Hormozdiari, Fereydoun; Koval, Vyacheslav; Medina-Gomez, Carolina; Oostra, Ben; Veldink, Jan, H; van den Berg, Leonard, H; Pitts, Steven, J; Potluri, Shobha; Sundar, Purnima; Cox, David, R; de Knijff, Peter; Li, Qibin; Li, Yingrui; Du, Yuanping; Chen, Ruoyan; Cao, Hongzhi; Wang, Jun; Li, Ning; Cao, Sujie; Bovenberg, Jasper, A; van Ommen, Gert-Jan B; Arakelyan, Arsen |
| Contributors: |
Russian-Armenian University (RAU); Bioinformatique, phylogénie et génomique évolutive LBBE (BPGE); Département PEGASE LBBE (PEGASE); Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE); Université de Lyon-Université de Lyon-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS) |
| Source: |
ISSN: 2045-2322. |
| Publisher Information: |
CCSD; Nature Publishing Group |
| Publication Year: |
2019 |
| Collection: |
HAL Lyon 1 (University Claude Bernard Lyon 1) |
| Subject Terms: |
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics; [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE] |
| Description: |
International audience ; Telomere length (TL) regulation is an important factor in ageing, reproduction and cancer development. Genetic, hereditary and environmental factors regulating TL are currently widely investigated, however, their relative contribution to TL variability is still understudied. We have used whole genome sequencing data of 250 family trios from the Genome of the Netherlands project to perform computational measurement of TL and a series of regression and genome-wide association analyses to reveal TL inheritance patterns and associated genetic factors. Our results confirm that TL is a largely heritable trait, primarily with mother’s, and, to a lesser extent, with father’s TL having the strongest influence on the offspring. In this cohort, mother’s, but not father’s age at conception was positively linked to offspring TL. Age-related TL attrition of 40 bp/year had relatively small influence on TL variability. Finally, we have identified TL-associated variations in ribonuclease reductase catalytic subunit M1 (RRM1 gene), which is known to regulate telomere maintenance in yeast. We also highlight the importance of multivariate approach and the limitations of existing tools for the analysis of TL as a polygenic heritable quantitative trait |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1038/s41598-019-55109-7 |
| Availability: |
https://cnrs.hal.science/hal-04604758; https://cnrs.hal.science/hal-04604758v1/document; https://cnrs.hal.science/hal-04604758v1/file/Nersisyan_telomere_length_GONL.SciRep.pdf; https://doi.org/10.1038/s41598-019-55109-7 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.F835FF98 |
| Database: |
BASE |