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Serum copper, rubidium, selenium, strontium, and zinc and psychophysical health in adults of the Sarno river Basin: PREVES-STOP 2025 community biomonitoring results

Title: Serum copper, rubidium, selenium, strontium, and zinc and psychophysical health in adults of the Sarno river Basin: PREVES-STOP 2025 community biomonitoring results
Authors: Scafuri, Luca; Baio, Raffaele; Buonerba, Carlo; Crocetto, Felice; Verde, Antonio; Ferraioli, Antonella; Riccio, Vittorio; Rizzano, Serena; Rizzano, Sara; Pisapia, Armando; Montanaro, Vittorino; Ronga, Emily; Romeo, Giuseppe; Ruffo, Antonio; Ferro, Matteo; Iuliano, Mauro; Trifuoggi, Marco; Marano, Alessandra; De Tommaso, Gaetano; Conte, Flavia; Di Trolio, Rossella; Strianese, Oriana; Vitolo, Alessia; Maglione, Luigia; Tarantino, Paola; Stanzione, Francesco; Cappuccio, Francesca; Costabile, Ferdinando; Di Lorenzo, Giuseppe
Contributors: Scafuri, Luca; Baio, Raffaele; Buonerba, Carlo; Crocetto, Felice; Verde, Antonio; Ferraioli, Antonella; Riccio, Vittorio; Rizzano, Serena; Rizzano, Sara; Pisapia, Armando; Montanaro, Vittorino; Ronga, Emily; Romeo, Giuseppe; Ruffo, Antonio; Ferro, Matteo; Iuliano, Mauro; Trifuoggi, Marco; Marano, Alessandra; De Tommaso, Gaetano; Conte, Flavia; Di Trolio, Rossella; Strianese, Oriana; Vitolo, Alessia; Maglione, Luigia; Tarantino, Paola; Stanzione, Francesco; Cappuccio, Francesca; Costabile, Ferdinando; Di Lorenzo, Giuseppe
Publication Year: 2026
Collection: IRIS Università degli Studi di Napoli Federico II
Subject Terms: Sarno river basin; copper; rubidium; selenium; strontium; zinc
Description: Evaluate associations between serum copper (Cu), rubidium (Rb), selenium (Se), strontium (Sr), and zinc (Zn) and psychophysical health in adults from Italy's Sarno River Basin within the 2025 PREVES-STOP program. Adults aged 30-65 completed validated questionnaires plus clinical evaluation and blood sampling. Elements were quantified by collision/reaction-cell inductively coupled plasma mass spectrometry (ICP-MS). Associations were evaluated using Spearman and partial Spearman correlations. Significant associations included Zn and Rb associated with lower odds (odds ratio, OR) of severe fatigue - Recognizing and Estimating Signs of Tiredness (REST): Zn OR=0.38, 95†̄% confidence interval (CI) 0.21-0.68, q=0.02; Rb OR=0.33, 95†̄% CI 0.15-0.71, q=0.03 - while Sr was associated with higher well-being - the World Health Organization-5 Well-Being Index (WHO-5) OR=1.36, 95†̄% CI 1.12-1.65, q=0.02. Findings support broader trace-element panels to inform psychophysical and cardiometabolic risk beyond classical toxic metals, complementing prior PREVES-STOP evidence on lead (Pb) and cadmium (Cd). Further investigation is warranted.
Document Type: article in journal/newspaper
Language: English
Relation: volume:Online ahead of print; numberofpages:13; journal:JOURNAL OF BASIC AND CLINICAL PHYSIOLOGY AND PHARMACOLOGY; https://hdl.handle.net/11588/1025641
DOI: 10.1515/jbcpp-2025-0195
DOI: 10.1515/jbcpp-2025-0195/html
Availability: https://hdl.handle.net/11588/1025641; https://doi.org/10.1515/jbcpp-2025-0195; https://www.degruyterbrill.com/document/doi/10.1515/jbcpp-2025-0195/html
Rights: info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc-nd/4.0/
Accession Number: edsbas.F853E5CD
Database: BASE