| Title: |
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes |
| Authors: |
Petrie, John R.; Boehnke, Mike; Ferrannini, Ele; Ríos, Manuel Serrano; Östenson, Claes Göran; Makrilakis, Konstantinos; Forsen, Tom J.; Osmond, Clive; Cooper, Cyrus C.; Dennison, Elaine M.; Jameson, Karen A.; Sayer, Avan A.; Kuulasmaa, Teemu; Stancakova, Alena; Lind, Lars; Mannila, Maria Nastase; Gu, Harvest; Zethelius, Björn; Turrini, Fabiola; Pascoe, Laura; Syvänen, Ann Christine; Ahlqvist, Emma; Horikoshi, Momoko; Barnes, Daniel; Luan, Jian'an; Han, Chen; Manning, Alisa K.; Rybin, Denis; Kanoni, Stavroula; Barker, Adam; Xie, Weijia; Gustafsson, Stefan; Eury, Elodie; Kerr-Conte, Julie; Pattou, François; Johnson, Paul; Folkersen, Lasse; Steinthorsdottir, Valgerdur; Dina, Christian; Zeggini, Eleftheria; Huth, Cornelia; Aulchenko, Yurii S.; McCulloch, Laura J.; Ferreira, Teresa; Wu, Guanming; Willer, Cristen J.; McCarroll, Steve A.; Langenberg, Claudia; Hofmann, Oliver M.; Dupuis, Josée; van Hoek, Mandy; Navarro, Pau; Ardlie, Kristin; Benediktsson, Rafn; Blagieva, Roza; Boström, Kristina Bengtsson; Bravenboer, Bert; Bumpstead, Suzannah; Burtt, Noisël P.; Charpentier, Guillaume; Cornelis, Marilyn; Couper, David J.; Crawford, Gabe; Doney, Alex S F; Elliott, Katherine S.; Elliott, Amanda L.; Franklin, Christopher S.; Ganser, Martha; Grarup, Niels; Green, Todd; Griffin, Simon; Hadjadj, Samy; Herder, Christian; Jackson, Anne U.; Johnson, Paul R V; Kao, Wen H L; Klopp, Norman; Lauritzen, Torsten; Li, Man; Lieverse, Aloysius; Lyssenko, Valeriya; Nilsson, Peter; Owen, Katharine R.; Payne, Felicity; Petersen, Ann Kristin; Platou, Carl; Proença, Christine; Rathmann, Wolfgang; Rayner, N. William; Rocheleau, Ghislain; Roden, Michael; Sampson, Michael J.; Saxena, Richa; Shields, Beverley M.; Shrader, Peter; Sigurdsson, Gunnar; Sparsø, Thomas; Strassburger, Klaus; Stringham, Heather M.; Sun, Qi; Thorand, Barbara; Tichet, Jean; van Dam, Rob M.; van Haeften, Timon W.; van Herpt, Thijs; van Vliet-Ostaptchouk, Jana V.; Bragi Walters, G.; Weedon, Michael N.; Wijmenga, Cisca; Witteman, Jacqueline; Cauchi, Stephane; Gloyn, Anna L.; Hide, Winston A.; Hitman, Graham A.; Morris, Andrew D.; Palmer, Colin N A; Sijbrands, Eric; Stein, Lincoln D.; Uitterlinden, Andre; Walker, Mark; Boehm, Bernhard O.; Daly, Mark J.; Meigs, James B.; Pankow, James S.; Florez, Jose C.; Groop, Leif; Sladek, Rob; Speliote, Elizabeth K.; Wille, Cristen J.; Bernd, Sonja I.; Mond, Keri L.; Thorleifsso, Gudmar; Jackso, Anne U.; Lango Allen, Hana; Lindgre, Cecilia M.; Lua, Jian'an; Mäg, Reedik; Randal, Joshua C.; Vedanta, Sailaja; Winkle, Thomas W.; Qi, Lu; Workalemah, Tsegaselassie; Hei, Iris M.; Steinthorsdotti, Valgerdur; Stringha, Heather M.; Weedo, Michael N.; Wheele, Eleanor; Woo, Andrew R.; Ferreir, Teresa; Weyan, Robert J.; Segrè, Ayellet V.; Estrad, Karol; Lian, Liming; Nemes, James; Par, Ju Hyun; Gustafsso, Stefan; Kilpeläine, Tuomas O.; Yang, Jian; Bouatia-Naji, Nabila; Esko, Tõnu; Feitosa, Mary F.; Kutalik, Zoltán; Mangino, Massimo; Raychaudhuri, Soumya; Scherag, Andre; Welch, Ryan; Zhao, Jing Hua; Aben, Katja K.; Amin, Najaf; Dixon, Anna L.; Fisher, Eva; Glazer, Nicole L.; Goddard, Michael E.; Heard-Costa, Nancy L.; Hoesel, Volker; Hottenga, Jouke Jan; Johansson, Åsa; Johnson, Toby; Ketkar, Shamika; Lamina, Claudia; Li, Shengxu; Moffatt, Miriam F.; Myers, Richard H.; Narisu, Narisu; Perry, John R B; Peters, Marjolein J.; Ripatti, Samuli; Rivadeneira, Fernando; Sandholt, Camilla; Scott, Laura J.; Timpson, Nicholas J.; Tyrer, Jonathan P.; van Wingerden, Sophie; Watanabe, Richard M.; White, Charles C.; Wiklund, Fredrik; Barlassina, Christina; Chasman, Daniel I.; Cooper, Matthew N.; Jansson, John Olov; Lawrence, Robert W.; Pellikka, Niina; Prokopenko, Inga; Shi, Jianxin; Thiering, Elisabeth; Alavere, Helene; Alibrandi, Maria T S; Almgren, Peter; Arnold, Alice M.; Aspelund, Thor; Atwood, Larry D.; Balkau, Beverley; Bennett, Amanda J.; Ben-Shlomo, Yoav; Bergman, Richard N.; Bergmann, Sven; Biebermann, Heike; Blakemore, Alexandra I F; Boes, Tanja; Bonnycastle, Lori L.; Bornstein, Stefan R.; Buchanan, Thomas A.; Busonero, Fabio; Campbell, Harry; Cappuccio, Francesco P.; Cavalcanti-Proença, Christine; Ida Chen, Yii Der; Chen, Chih Mei; Chines, Peter S.; Coin, Lachlan; Connell, John; Day, Ian N M; den Heijer, Martin; Duan, Jubao; Ebrahim, Shah; Eiriksdottir, Gudny; Erdos, Michael R.; Eriksson, Johan G.; Facheris, Maurizio F.; Felix, Stephan B.; Fischer-Posovszky, Pamela; Friedrich, Nele; Freimer, Nelson B.; Fu, Mao; Gaget, Stefan; Gejman, Pablo V.; Geus, Eco J C; Gjesing, Anette P.; Goyette, Philippe; Grallert, Harald; Gräßler, Jürgen; Greenawalt, Danielle M.; Groves, Christopher J.; Guiducci, Candace; Hartikainen, Anna Liisa; Havulinna, Aki S.; Hayward, Caroline; Heath, Andrew C.; Hicks, Andrew A.; Hinney, Anke; Homuth, Georg; Hui, Jennie; Igl, Wilmar; Isomaa, Bo; Jacobs, Kevin B.; Jarick, Ivonne; Jewell, Elizabeth; John, Ulrich; Jørgensen, Torben; Jousilahti, Pekka; Jula, Antti; Kaakinen, Marika; Kajantie, Eero; Kettunen, Johannes; Kinnunen, Leena; Kolcic, Ivana; Koskinen, Seppo; Kovacs, Peter; Kuusisto, Johanna; Kraft, Peter; Kvaløy, Kirsti; Laitinen, Jaana; Lantieri, Olivier; Lanzani, Chiara; Launer, Lenore J.; Lecoeur, Cecile; Lehtimäki, Terho; Liu, Jianjun; Lokki, Marja Liisa; Lorentzon, Mattias; Luben, Robert N.; Ludwig, Barbara; Manunta, Paolo; Marek, Diana; Marre, Michel; Martin, Nicholas G.; McArdle, Wendy L.; McCarthy, Anne; McKnight, Barbara; Meyre, David; Midthjell, Kristian; Montgomery, Grant W.; Morken, Mario A.; Morris, Andrew P.; Mulic, Rosanda; Ngwa, Julius S.; Nelis, Mari; Neville, Matt J.; Nyholt, Dale R.; O'Donnel, Christopher J.; O'Rahilly, Stephen; Ong, Ken K.; Oostra, Ben; Paré, Guillaume; Parker, Alex N.; Perola, Markus; Pichler, Irene; Pietiläinen, Kirsi H.; Platou, Carl G P; Polasek, Ozren; Pouta, Anneli; Rafelt, Suzanne; Raitakari, Olli; Rayner, Nigel W.; Ridderstråel, Martin; Rief, Winfried; Ruokonen, Aimo; Robertson, Neil R.; Rzehak, Peter; Sanders, Alan R.; Sandhu, Manjinder S.; Sanna, Serena; Saramies, Jouko; Savolainen, Markku J.; Scherag, Susann; Schipf, Sabine; Silander, Kaisa; Sinisalo, Juha; Smit, Jan H.; Sovio, Ulla; Stephens, Jonathan; Surakka, Ida; Swift, Amy J.; Tammesoo, Mari Liis; Tardif, Jean Claude; Teder-Laving, Maris; Teslovich, Tanya M.; Thomson, Brian; Tönjes, Anke; Tuomi, Tiinamaija; van Meurs, Joyce B.; van Ommen, Gert Jan; Vatin, Vincent; Viikari, Jorma; Visvikis-Siest, Sophie; Vitart, Veronique; Vogel, Carla I G; Waite, Lindsay L.; Wallaschofski, Henri; Walter, G. Bragi; Widen, Elisabeth; Wiegand, Susanna; Wild, Sarah H.; Willemsen, Gonneke; Witte, Daniel R.; Witteman, Jacqueline C.; Xu, Jianfeng; Zhang, Qunyuan; Zgaga, Lina; Zitting, Paavo; Beilby, John P.; Farooqi, I. Sadaf; Hebebrand, Johannes; Huikuri, Heikki V.; James, Alan L.; Kähönen, Mika; Levinson, Douglas F.; Macciardi, Fabio; Nieminen, Markku S.; Ohlsson, Claes; Palmer, Lyle J.; Ridker, Paul M.; Stumvoll, Michael; Beckmann, Jacques S.; Boeing, Heiner; Boomsma, Dorret I.; Chanock, Stephen J.; Collins, Francis S.; Smith, George Davey; Grönberg, Henrik; Gyllensten, Ulf; Hall, Per; Hansen, Torben; Harris, Tamara B.; Hattersley, Andrew T.; Hayes, Richard B.; Heinrich, Joachim; Hu, Frank B.; Hveem, Kristian; Jarvelin, Marjo Riitta; Kaprio, Jaakko; Karpe, Fredrik; Kiemeney, Lambertus A.; Krude, Heiko; Laakso, Markku; Lawlor, Debbie A.; Metspalu, Andres; Munroe, Patricia B.; Pedersen, Oluf; Penninx, Brenda W.; Pramstaller, Peter P.; Reinehr, Thomas; Rissanen, Aila; Rudan, Igor; Schwarz, Peter E H; Shuldiner, Alan R.; Tuomilehto, Jaakko; Uda, Manuela; Uitterlinden, André; Valle, Timo T.; Wabitsch, Martin; Waeber, Gérard; Wareham, Nicholas J.; Wilson, James F.; Wright, Alan F.; Zillikens, M. Carola; Chatterjee, Nilanjan; McCarroll, Steven A.; Purcell, Shaun; Visscher, Peter M.; Borecki, Ingrid B.; Fox, Caroline S.; Groop, Leif C.; Haritunians, Talin; Hunter, David J.; Kaplan, Robert C.; Mohlke, Karen L.; O'Connell, Jeffrey R.; Peltonen, Leena; Schlessinger, David; Strachan, David P.; van Duijn, Cornelia M.; Frayling, Timothy M.; Abecasis, Gonçalo R.; Boehnke, Michael; North, Kari E.; Hirschhorn, Joel N.; Ingelsson, Erik; Loos, Ruth J F; Nica, Alexandra C.; Parts, Leopold; Glass, Daniel; Nisbet, James; Barrett, Amy; Sekowska, Magdalena; Travers, Mary; Potter, Simon; Grundberg, Elin; Small, Kerrin; Hedman, Åsa K.; Bataille, Veronique; Tzenova Bell, Jordana; Surdulescu, Gabriela; Dimas, Antigone S.; Ingle, Catherine; Nestle, Frank O.; di Meglio, Paola; Min, Josine L.; Wilk, Alicja; Hammond, Christopher J.; Hassanali, Neelam; Yang, Tsun Po; Montgomery, Stephen B.; O'Rahilly, Steve; Lindgren, Cecilia M.; Zondervan, Krina T.; Barroso, Inês; Durbin, Richard; Ahmadi, Kourosh; Dermitzakis, Emmanouil T.; Spector, Timothy D.; Schunkert, Heribert; König, Inke R.; Kathiresan, Sekar; Reilly, Muredach P.; Assimes, Themistocles L.; Holm, Hilma; Preuss, Michael; Stewart, Alexandre F R; Barbalic, Maja; Gieger, Christian; Absher, Devin; Aherrahrou, Zouhair; Allayee, Hooman; Altshuler, David; Anand, Sonia S.; Andersen, Karl; Anderson, Jeffrey L.; Ardissino, Diego; Ball, Stephen G.; Balmforth, Anthony J.; Barnes, Timothy A.; Becker, Diane M.; Becker, Lewis C.; Berger, Klaus; Bis, Joshua C.; Boekholdt, S. Matthijs; Boerwinkle, Eric; Braund, Peter S.; Brown, Morris J.; Burnett, Mary Susan; Buysschaert, Ian; Carlquist, John F.; Chen, Li; Cichon, Sven; Codd, Veryan; Davies, Robert W.; Dedoussis, George; Dehghan, Abbas; Demissie, Serkalem; Devaney, Joseph M.; Diemert, Patrick; Do, Ron; Doering, Angela; Eifert, Sandra; El Mokhtari, Nour Eddine; Ellis, Stephen G.; Elosua, Roberto; Engert, James C.; Epstein, Stephen E.; de Faire, Ulf; Fischer, Marcus; Folsom, Aaron R.; Freyer, Jennifer; Gigante, Bruna; Girelli, Domenico; Gretarsdottir, Solveig; Gudnason, Vilmundur; Gulcher, Jeffrey R.; Halperin, Eran; Hammond, Naomi; Hazen, Stanley L.; Hofman, Albert; Horne, Benjamin D.; Illig, Thomas; Iribarren, Carlos; Jones, Gregory T.; Jukema, J. Wouter; Kaiser, Michael A.; Kaplan, Lee M.; Kastelein, John J P; Khaw, Kay Tee; Knowles, Joshua W.; Kolovou, Genovefa; Kong, Augustine; Laaksonen, Reijo; Lambrechts, Diether; Leander, Karin; Lettre, Guillaume; Li, Mingyao; Lieb, Wolfgang; Loley, Christina; Lotery, Andrew J.; Mannucci, Pier M.; Maouche, Seraya; Martinelli, Nicola; McKeown, Pascal P.; Meisinger, Christa; Meitinger, Thomas; Melander, Olle; Merlini, Pier Angelica; Mooser, Vincent; Morgan, Thomas; Mühleisen, Thomas W.; Muhlestein, Joseph B.; Münzel, Thomas; Musunuru, Kiran; Nahrstaedt, Janja; Nelson, Christopher P.; Nöthen, Markus M.; Olivieri, Oliviero; Patel, Riyaz S.; Patterson, Chris C.; Peters, Annette; Peyvandi, Flora; Qu, Liming; Quyyumi, Arshed A.; Rader, Daniel J.; Rallidis, Loukianos S.; Rice, Catherine; Rosendaal, Frits R.; Rubin, Diana; Salomaa, Veikko; Sampietro, M. Lourdes; Sandhu, Manj S.; Schadt, Eric; Schäfer, Arne; Schillert, Arne; Schreiber, Stefan; Schrezenmeir, Jürgen; Schwartz, Stephen M.; Siscovick, David S.; Sivananthan, Mohan; Sivapalaratnam, Suthesh; Smith, Albert; Smith, Tamara B.; Snoep, Jaapjan D.; Soranzo, Nicole; Spertus, John A.; Stark, Klaus; Stirrups, Kathy; Stoll, Monika; Tang, W. H Wilson; Tennstedt, Stephanie; Thorgeirsson, Gudmundur; Thorleifsson, Gudmar; Tomaszewski, Maciej; Uitterlinden, Andre G.; van Rij, Andre M.; Voight, Benjamin F.; Wareham, Nick J.; Wells, George A.; Wichmann, H. Erich; Wild, Philipp S.; Willenborg, Christina; Witteman, Jaqueline C M; Wright, Benjamin J.; Ye, Shu; Zeller, Tanja; Ziegler, Andreas; Cambien, Francois; Goodall, Alison H.; Cupples, L. Adrienne; Quertermous, Thomas; März, Winfried; Hengstenberg, Christian; Blankenberg, Stefan; Ouwehand, Willem H.; Hall, Alistair S.; Thompson, John R.; Stefansson, Kari; Roberts, Robert; Thorsteinsdottir, Unnur; O'Donnell, Christopher J.; McPherson, Ruth; Erdmann, Jeanette; Parish, Sarah; Offer, Alison; Bowman, Louise; Sleight, Peter; Armitage, Jane; Peto, Richard; Chambers, John C.; Abecasis, Goncalo; Ahmed, Nabeel; Caulfield, Mark; Donnelly, Peter; Elliott, Paul; Froguel, Philippe; Kooner, Angad S.; McCarthy, Mark; Scott, James; Sehmi, Joban; Zhang, Weihua; Kooner, Jaspal S.; Strawbridge, Rona; Sabater-Lleal, Maria; Mälarstig, Anders; Sennblad, Bengt; Öhrvik, John; Silveira, Angela; van't Hooft, Ferdinand; Eriksson, Per; Hamsten, Anders; Hellénius, Mai Lis; Olsson, Gunnar; Rust, Stephan; Assmann, Gerd; Seedorf, Udo; Barlera, Simona; Franzosi, Maria Grazia; Tognoni, Gianni; Clarke, Robert; Linksted, Pamela; Hopewell, Jemma C.; Collins, Rory; Peden, John F.; Goel, Anuj; Ongen, Halit; Kyriakou, Theodosios; Green, Fiona; Farrall, Martin; Watkins, Hugh; Saleheen, Danish; Rasheed, Asif; Zaidi, Moazzam; Shah, Nabi; Samuel, Maria; Mallick, Nadeem; Azhar, Muhammad; Zaman, Khan Shah; Samad, Adbus; Ishaq, Muhammad; Gardezi, Ali; Memon, Fazal ur Rehman; Samani, Nilesh; Frossard, Philippe; Deloukas, Panos; Danesh, John; Chen, Han; Taneera, Jalal; Zabena, Carina; Barker, David J P; Martínez-Larrad, María Teresa; Ohrvik, John; Ostenson, Claes-Göran; van Vliet, Jana V; Speliotes, Elizabeth K; Berndt, Sonja I; Monda, Keri L; Mägi, Reedik; Randall, Joshua C; Vedantam, Sailaja; Winkler, Thomas W; Workalemahu, Tsegaselassie; Heid, Iris M; Wheeler, Eleanor; Wood, Andrew R; Weyant, Robert J; Estrada, Karol; Liang, Liming; Nemesh, James; Park, Ju-Hyun; Kilpeläinen, Tuomas O; Terho, Lehtimäki; MAGIC, Unknown; Ridderstråle, Martin; Dorret I, Boomsma; Shaun, Purcell; Eric E, Schadt; Peter M, Visscher; Barroso, H; Cardiogenics, Unknown; Nilesh J, Samani |
| Source: |
Petrie, J R, Boehnke, M, Ferrannini, E, Ríos, M S, Östenson, C G, Makrilakis, K, Forsen, T J, Osmond, C, Cooper, C C, Dennison, E M, Jameson, K A, Sayer, A A, Kuulasmaa, T, Stancakova, A, Lind, L, Mannila, M N, Gu, H, Zethelius, B, Turrini, F, Pascoe, L, Syvänen, A C, Ahlqvist, E, Horikoshi, M, Barnes, D, Luan, J, Han, C, Manning, A K, Rybin, D, Kanoni, S, Barker, A, Xie, W, Gustafsson, S, Eury, E, Kerr-Conte, J, Pattou, F, Johnson, P, Folkersen, L, Steinthorsdottir, V, Dina, C, Zeggini, E, Huth, C, Aulchenko, Y S, McCulloch, L J, .... |
| Publication Year: |
2011 |
| Collection: |
The University of Manchester: Research Explorer - Publications |
| Description: |
OBJECTIVE - Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired b-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS - We have conducted a meta-analysis of genome-wide association tests of ;2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS - Nine SNPs at eight loci were associated with proinsulin levels (P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0012-1797 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/21873549; info:eu-repo/semantics/altIdentifier/eissn/0012-1797 |
| DOI: |
10.2337/db11-0415 |
| Availability: |
https://research.manchester.ac.uk/en/publications/3eea551c-6b01-421a-830b-9ec1b90b6111; https://doi.org/10.2337/db11-0415; http://diabetes.diabetesjournals.org/content/60/10/2624.full.pdf+html |
| Rights: |
info:eu-repo/semantics/closedAccess |
| Accession Number: |
edsbas.F88EDF49 |
| Database: |
BASE |