Independent serum metabolomics approaches identify disrupted glutamic acid and serine metabolism in Parkinson’s disease patients
| Title: | Independent serum metabolomics approaches identify disrupted glutamic acid and serine metabolism in Parkinson’s disease patients |
|---|---|
| Authors: | Gervasoni J.; Marino C.; Imarisio A.; Santucci L.; Napolitano E.; Nuzzo T.; Yahyavi I.; Avenali M.; Cicchinelli M.; Buongarzone G.; Galandra C.; Picascia M.; Grimaldi M.; Pacchetti C.; Errico F.; D'Ursi A. M.; Urbani A.; Valente E. M.; Usiello A. |
| Contributors: | Gervasoni, J.; Marino, C.; Imarisio, A.; Santucci, L.; Napolitano, E.; Nuzzo, T.; Yahyavi, I.; Avenali, M.; Cicchinelli, M.; Buongarzone, G.; Galandra, C.; Picascia, M.; Grimaldi, M.; Pacchetti, C.; Errico, F.; D'Ursi, A. M.; Urbani, A.; Valente, E. M.; Usiello, A. |
| Publication Year: | 2025 |
| Collection: | Università degli Studi della Campania "Luigi Vanvitelli": CINECA IRIS V: |
| Description: | Whether distinct blood metabolomic profiles can distinguish Parkinson’s disease (PD) patients from healthy controls (HC) is still a matter of debate. Here, we employed 1H-NMR and UPLC/MS analyses on serum samples from a cohort of PD patients and HC. Compared to HC, PD patients showed: (1) higher glutamine, serine, pyruvate and lower α-ketoglutarate levels (1H-NMR); (2) higher glycine and lower glutamic acid concentrations (UPLC/MS). Several pathways associated with amino acids, mitochondrial and antioxidant metabolism emerged as dysregulated in PD. Our findings highlight a prominent disruption of cellular bioenergetic pathways and amino acid homeostasis in PD. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/40998834; info:eu-repo/semantics/altIdentifier/wos/WOS:001578783900003; volume:11; issue:1; journal:NPJ PARKINSON'S DISEASE; https://hdl.handle.net/11591/583266 |
| DOI: | 10.1038/s41531-025-01126-5 |
| Availability: | https://hdl.handle.net/11591/583266; https://doi.org/10.1038/s41531-025-01126-5 |
| Accession Number: | edsbas.F8D46B5 |
| Database: | BASE |