| Title: |
Extreme Phenotype Approach Suggests Taste Transduction Pathway for Carotid Plaque in a Multi-Ethnic Cohort |
| Authors: |
Dueker, Nicole D; Doliner, Brett; Gardener, Hannah; Dong, Chuanhui; Beecham, Ashley; Della-Morte, David; Sacco, Ralph L; Blanton, Susan H; Wang, Liyong; Rundek, Tatjana |
| Contributors: |
Dueker, Nd; Doliner, B; Gardener, H; Dong, C; Beecham, A; Della-Morte, D; Sacco, Rl; Blanton, Sh; Wang, L; Rundek, T |
| Publisher Information: |
LIPPINCOTT WILLIAMS & WILKINS |
| Publication Year: |
2021 |
| Collection: |
Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| Subject Terms: |
atherosclerosis; diabetes mellitus; genome-wide association study; hypertension; population; Settore MED/09 - MEDICINA INTERNA |
| Description: |
Background and Purpose: Carotid plaque is a heritable trait and a strong predictor of vascular events. Several loci have been identified for carotid plaque, however, studies in minority populations are lacking. Within a multi-ethnic cohort, we have identified individuals with extreme total carotid plaque area (TCPA), that is, higher or lower TCPA than expected based on traditional vascular risk factors (age, sex, smoking, diabetes mellitus, hypertension, etc). We hypothesized that these individuals are enriched with genetic variants accounting for the plaque burden that cannot be explained by traditional vascular risk factors. Herein, we sought to identify the genetic basis for TCPA using the multi-ethnic cohort. Methods: Three hundred forty participants (170 from each extreme group) from 3 race/ethnic groups (53% Hispanic, 29% non-Hispanic Black, and 18% non-Hispanic White) were genotyped using a genome-wide single-nucleotide polymorphism (SNP) array and imputed using 1000Genome data. SNP-based analyses using logistic regression and gene-based analyses using VEGAS2 were performed within each race/ethnic group and then meta-analyzed. Genes withPResults: No SNP or gene reached genome-wide significance. In the pathway analysis, GO:0050913 (sensory perception of bitter taste) gene set was significantly enriched (P=4.5x10(-6), false discovery rate=0.04), which was confirmed in MEGASTROKE (P=0.01). Within the GO:0050913 gene set, 3 genes were associated with extreme TCPA in our study (P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/32811377; info:eu-repo/semantics/altIdentifier/wos/WOS:000565641800044; volume:51; issue:9; firstpage:2761; lastpage:2769; numberofpages:9; journal:STROKE; https://hdl.handle.net/2108/322160 |
| DOI: |
10.1161/STROKEAHA.120.028979 |
| Availability: |
https://hdl.handle.net/2108/322160; https://doi.org/10.1161/STROKEAHA.120.028979 |
| Rights: |
info:eu-repo/semantics/restrictedAccess ; license:Non specificato ; license uri:iris.na |
| Accession Number: |
edsbas.F8FA6540 |
| Database: |
BASE |