Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies
| Title: | Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies |
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| Authors: | Assimes TL; Hólm H; Kathiresan S; Reilly MP; Thorleifsson G; Voight BF; Erdmann J; Willenborg C; Vaidya D; Xie C; Patterson CC; Morgan TM; Burnett MS; Li M; Hlatky MA; Knowles JW; Thompson JR; Absher D; Iribarren C; Go A; Fortmann SP; Sidney S; Risch N; Tang H; Myers RM; Berger K; Stoll M; Shah SH; Thorgeirsson G; Andersen K; Havulinna AS; Herrera JE; Faraday N; Kim Y; Kral BG; Mathias RA; Ruczinski I; Suktitipat B; Wilson AF; Yanek LR; Becker LC; Linsel Nitschke P; Lieb W; König IR; Hengstenberg C; Fischer M; Stark K; Reinhard W; Winogradow J; Grassl M; Grosshennig A; Preuss M; Schreiber S; Wichmann HE; Meisinger C; Yee J; Friedlander Y; Do R; Meigs JB; Williams G; Nathan DM; MacRae CA; Qu L; Wilensky RL; Matthai WH Jr; Qasim AN; Hakonarson H; Pichard AD; Kent KM; Satler L; Lindsay JM; Waksman R; Knouff CW; Waterworth DM; Walker MC; Mooser VE; Marrugat J; Lucas G; Subirana I; Sala J; Ramos R; MARTINELLI, Nicola; OLIVIERI, Oliviero; TRABETTI, Elisabetta; MALERBA, Giovanni; PIGNATTI, Pierfranco; Guiducci C; Mirel D; Parkin M; Hirschhorn JN; Asselta R; Duga S; Musunuru K; Daly MJ; Purcell S; Eifert S; Braund PS; Wright BJ; Balmforth AJ; Ball SG; Myocardial Infarction Genetics Consortium; Wellcome Trust Case Control Consortium; Cardiogenics; Ouwehand WH; Deloukas P; Scholz M; Cambien F; Huge A; Scheffold T; Salomaa V; GIRELLI, Domenico; Granger CB; Peltonen L; McKeown PP; Altshuler D; Melander O; Devaney JM; Epstein SE; Rader DJ; Elosua R; Engert JC; Anand SS; Hall AS; Ziegler A; O'Donnell CJ; Spertus JA; Siscovick D; Schwartz SM; Becker D; Thorsteinsdottir U; Stefansson K; Schunkert H; Samani NJ; Quertermous T. |
| Contributors: | Assimes, Tl; Hólm, H; Kathiresan, S; Reilly, Mp; Thorleifsson, G; Voight, Bf; Erdmann, J; Willenborg, C; Vaidya, D; Xie, C; Patterson, Cc; Morgan, Tm; Burnett, M; Li, M; Hlatky, Ma; Knowles, Jw; Thompson, Jr; Absher, D; Iribarren, C; Go, A; Fortmann, Sp; Sidney, S; Risch, N; Tang, H; Myers, Rm; Berger, K; Stoll, M; Shah, Sh; Thorgeirsson, G; Andersen, K; Havulinna, A; Herrera, Je; Faraday, N; Kim, Y; Kral, Bg; Mathias, Ra; Ruczinski, I; Suktitipat, B; Wilson, Af; Yanek, Lr; Becker, Lc; Linsel Nitschke, P; Lieb, W; König, Ir; Hengstenberg, C; Fischer, M; Stark, K; Reinhard, W; Winogradow, J; Grassl, M; Grosshennig, A; Preuss, M; Schreiber, S; Wichmann, He; Meisinger, C; Yee, J; Friedlander, Y; Do, R; Meigs, Jb; Williams, G; Nathan, Dm; Macrae, Ca; Qu, L; Wilensky, Rl; Matthai WH, Jr; Qasim, An; Hakonarson, H; Pichard, Ad; Kent, Km; Satler, L; Lindsay, Jm; Waksman, R; Knouff, Cw; Waterworth, Dm; Walker, Mc; Mooser, Ve; Marrugat, J; Lucas, G; Subirana, I; Sala, J; Ramos, R; Martinelli, Nicola; Olivieri, Oliviero; Trabetti, Elisabetta; Malerba, Giovanni; Pignatti, Pierfranco; Guiducci, C; Mirel, D; Parkin, M; Hirschhorn, Jn; Asselta, R; Duga, S; Musunuru, K; Daly, Mj; Purcell, S; Eifert, S; Braund, P; Wright, Bj; Balmforth, Aj; Ball, Sg |
| Publication Year: | 2010 |
| Collection: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| Subject Terms: | coronary artery disease; KIF6; kinesin-like protein 6; myocardial infarction; polymorphism |
| Description: | OBJECTIVES: We sought to replicate the association between the kinesin-likeprotein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary arterydisease (CAD).BACKGROUND: Recent prospective studies suggest that carriers of the 719Arg allelein KIF6 are at increased risk of clinical CAD compared with noncarriers.METHODS: The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19case-control studies of nonfatal CAD either as part of a genome-wide association study or in a formal attempt to replicate the initial positive reports.RESULTS: A total of 17,000 cases and 39,369 controls of European descent as well as a modest number of South Asians, African Americans, Hispanics, East Asians,and admixed cases and controls were successfully genotyped. None of the 19studies demonstrated an increased risk of CAD in carriers of the 719Arg allelecompared with noncarriers. Regression analyses and fixed-effects meta-analysesruled out with high degree of confidence an increase of ≥2% in the risk of CADamong European 719Arg carriers. We also observed no increase in the risk of CADamong 719Arg carriers in the subset of Europeans with early-onset disease(younger than 50 years of age for men and younger than 60 years of age for women)compared with similarly aged controls as well as all non-European subgroups.CONCLUSIONS: The KIF6 Trp719Arg polymorphism was not associated with the risk of clinical CAD in this large replication study. |
| Document Type: | article in journal/newspaper |
| File Description: | STAMPA |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/20933357; info:eu-repo/semantics/altIdentifier/wos/WOS:000283538000005; volume:56; issue:19; firstpage:1552; lastpage:1563; numberofpages:12; journal:JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY; https://hdl.handle.net/11562/348694; https://doi.org/10.1016/j.jacc.2010.06.022 |
| DOI: | 10.1016/j.jacc.2010.06.022 |
| Availability: | https://hdl.handle.net/11562/348694; https://doi.org/10.1016/j.jacc.2010.06.022 |
| Rights: | info:eu-repo/semantics/closedAccess ; license:Accesso ristretto |
| Accession Number: | edsbas.F93F20B9 |
| Database: | BASE |