| Title: |
Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study |
| Authors: |
Drake, TM; Riad, AM; Fairfield, CJ; Egan, C; Knight, SR; Pius, R; Hardwick, HE; Norman, L; Shaw, CA; McLean, KA; Thompson, AAR; Ho, A; Swann, OV; Sullivan, M; Soares, F; Holden, KA; Merson, L; Plotkin, D; Sigfrid, L; de Silva, TI; Girvan, M; Jackson, C; Russell, CD; Dunning, J; Solomon, T; Carson, G; Olliaro, P; Nguyen-Van-Tam, JS; Turtle, L; Docherty, AB; Openshaw, PJM; Baillie, JK; Harrison, EM; Semple, MG; Alex, B; Bach, B; Barclay, WS; Bogaert, D; Chand, M; Cooke, GS; da Silva Filipe, A; Fletcher, T; Green, CA; Hiscox, JA; Ho, AYW; Horby, PW; Ijaz, S; Khoo, S; Klenerman, P; Law, A; Lim, WS; Mentzer, AJ; Meynert, AM; Noursadeghi, M; Moore, SC; Palmarini, M; Paxton, WA; Pollakis, G; Price, N; Rambaut, A; Robertson, DL; Sancho-Shimizu, V; Scott, JT; de Silva, T; Sriskandan, S; Stuart, D; Summers, C; Tedder, RS; Thomson, EC; Thwaites, RS; Turtle, LCW; Gupta, RK; Palmieri, C; Zambon, M; Dumas, M-E; Griffin, J; Takats, Z; Chechi, K; Andrikopoulos, P; Osagie, A; Olanipekun, M; Liggi, S; Lewis, M; dos Santos Correia, G; Sands, C; Takis, P; Maslen, L; Hardwick, H; Donohue, C; Griffiths, F; Oosthuyzen, W; Mclean, KA; Murphy, D; Dalton, J; Saviciute, E; Roberts, S; Harrison, J; Marsh, L; Connor, M; Halpin, S; Gamble, C; Lee, J; Leeming, G; Wham, M; Clohisey, S; Hendry, R; Scott-Brown, J; Greenhalf, W; Shaw, V; McDonald, SE; Keating, S; Ahmed, KA; Armstrong, JA; Ashworth, M; Asiimwe, IG; Bakshi, S; Barlow, SL; Booth, L; Brennan, B; Bullock, K; Catterall, BWA; Clark, JJ; Clarke, EA; Cole, S; Cooper, L; Cox, H; Davis, C; Dincarslan, O; Dunn, C; Dyer, P; Elliott, A; Evans, A; Finch, L; Fisher, LWS; Foster, T; Garcia-Dorival, I; Gunning, P; Hartley, C; Jensen, RL; Jones, CB; Jones, TR; Khandaker, S; King, K; Kiy, RT; Koukorava, C; Lake, A; Lant, S; Latawiec, D; Lavelle-Langham, L; Lefteri, D; Lett, L; Livoti, LA; Mancini, M; McDonald, S; McEvoy, L; McLauchlan, J; Metelmann, S; Miah, NS; Middleton, J; Mitchell, J; Murphy, EG; Penrice-Randal, R; Pilgrim, J; Prince, T; Reynolds, W; Ridley, PM; Sales, D; Shaw, VE; Shears, RK; Small, B; Subramaniam, KS; Szemiel, A; Taggart, A; Tanianis-Hughes, J; Thomas, J; Trochu, E; van Tonder, L; Wilcock, E; Zhang, JE; Flaherty, L; Maziere, N; Cass, E; Doce Carracedo, A; Carlucci, N; Holmes, A; Massey, H; Murphy, L; Wrobel, N; McCafferty, S; Morrice, K; MacLean, A; Adeniji, K; Agranoff, D; Agwuh, K; Ail, D; Aldera, EL; Alegria, A; Angus, B; Ashish, A; Atkinson, D; Bari, S; Barlow, G; Barnass, S; Barrett, N; Bassford, C; Basude, S; Baxter, D; Beadsworth, M; Bernatoniene, J; Berridge, J; Best, N; Bothma, P; Chadwick, D; Brittain-Long, R; Bulteel, N; Burden, T; Burtenshaw, A; Caruth, V; Chambler, D; Chee, N; Child, J; Chukkambotla, S; Clark, T; Collini, P; Cosgrove, C; Cupitt, J; Cutino-Moguel, M-T; Dark, P; Dawson, C; Dervisevic, S; Donnison, P; Douthwaite, S; Drummond, A; DuRand, I; Dushianthan, A; Dyer, T; Evans, C; Eziefula, C; Fegan, C; Finn, A; Fullerton, D; Garg, S; Garg, A; Gkrania-Klotsas, E; Godden, J; Goldsmith, A; Graham, C; Hardy, E; Hartshorn, S; Harvey, D; Havalda, P; Hawcutt, DB; Hobrok, M; Hodgson, L; Hormis, A; Jacobs, M; Jain, S; Jennings, P; Kaliappan, A; Kasipandian, V; Kegg, S; Kelsey, M; Kendall, J; Kerrison, C; Kerslake, I; Koch, O; Koduri, G; Koshy, G; Laha, S; Laird, S; Larkin, S; Leiner, T; Lillie, P; Limb, J; Linnett, V; Little, J; Lyttle, M; MacMahon, M; MacNaughton, E; Mankregod, R; Masson, H; Matovu, E; McCullough, K; McEwen, R; Meda, M; Mills, G; Minton, J; Mirfenderesky, M; Mohandas, K; Mok, Q; Moon, J; Moore, E; Morgan, P; Morris, C; Mortimore, K; Moses, S; Mpenge, M; Mulla, R; Murphy, M; Nagel, M; Nagarajan, T; Nelson, M; Norris, L; O'Shea, MK; Otahal, I; Ostermann, M; Pais, M; Panchatsharam, S; Papakonstantinou, D; Paraiso, H; Patel, B; Pattison, N; Pepperell, J; Peters, M; Phull, M; Pintus, S; Singh Pooni, J; Post, F; Price, D; Prout, R; Rae, N; Reschreiter, H; Reynolds, T; Richardson, N; Roberts, M; Roberts, D; Rose, A; Rousseau, G; Ryan, B; Saluja, T; Shah, A; Shanmuga, P; Sharma, A; Shawcross, A; Sizer, J; Shankar-Hari, M; Smith, R; Snelson, C; Spittle, N; Staines, N; Stambach, T; Stewart, R; Subudhi, P; Szakmany, T; Tatham, K; Thompson, C; Thompson, R; Tridente, A; Tupper-Carey, D; Twagira, M; Vallotton, N; Vancheeswaran, R; Vincent-Smith, L; Visuvanathan, S; Vuylsteke, A; Waddy, S; Wake, R; Walden, A; Welters, I; Whitehouse, T; Whittaker, P; Whittington, A; Papineni, P; Wijesinghe, M; Williams, M; Wilson, L; Sarah, S; Winchester, S; Wiselka, M; Wolverson, A; Wootton, DG; Workman, A; Yates, B; Young, P |
| Publisher Information: |
Elsevier BV |
| Publication Year: |
2021 |
| Collection: |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
| Description: |
Background COVID-19 is a multisystem disease and patients who survive might have in-hospital complications. These complications are likely to have important short-term and long-term consequences for patients, health-care utilisation, health-care system preparedness, and society amidst the ongoing COVID-19 pandemic. Our aim was to characterise the extent and effect of COVID-19 complications, particularly in those who survive, using the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK. Methods We did a prospective, multicentre cohort study in 302 UK health-care facilities. Adult patients aged 19 years or older, with confirmed or highly suspected SARS-CoV-2 infection leading to COVID-19 were included in the study. The primary outcome of this study was the incidence of in-hospital complications, defined as organ-specific diagnoses occurring alone or in addition to any hallmarks of COVID-19 illness. We used multilevel logistic regression and survival models to explore associations between these outcomes and in-hospital complications, age, and pre-existing comorbidities. Findings Between Jan 17 and Aug 4, 2020, 80 388 patients were included in the study. Of the patients admitted to hospital for management of COVID-19, 49·7% (36 367 of 73 197) had at least one complication. The mean age of our cohort was 71·1 years (SD 18·7), with 56·0% (41 025 of 73 197) being male and 81·0% (59 289 of 73 197) having at least one comorbidity. Males and those aged older than 60 years were most likely to have a complication (aged ≥60 years: 54·5% [16 579 of 30 416] in males and 48·2% [11 707 of 24 288] in females; aged |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
0140-6736 |
| Relation: |
https://eprints.whiterose.ac.uk/id/eprint/176374/1/1-s2.0-S0140673621007996-main.pdf; Drake, TM, Riad, AM, Fairfield, CJ et al. (400 more authors) (2021) Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. The Lancet, 398 (10296). pp. 223-237. ISSN: 0140-6736 |
| Availability: |
https://eprints.whiterose.ac.uk/id/eprint/176374/ |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.F943FDA7 |
| Database: |
BASE |