| Title: |
Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children |
| Authors: |
Bastard, P.; Gervais, A.; Taniguchi, M.; Saare, L.; Särekannu, K.; Voyer, T.L.; Philippot, Q.; Rosain, J.; Bizien, L.; Asano, T.; Garcia-Prat, M.; Parra-Martínez, A.; Migaud, M.; Tsumura, M.; Conti, F.; Belot, A.; Rivière, J.G.; Morio, T.; Tanaka, J.; Javouhey, E.; Haerynck, F.; Duvlis, S.; Özcelik, T.; Keles, S.; Tandjaoui-Lambiotte ,Y.; Escoda, S.; Husain, M.; Pan-Hammarström, Q.; Hammarström, L.; Ahlijah, G.; Haidar ,A.A.; Soudee, C.; Arseguel, V.; Abolhassani, H.; Sahanic, S.; Tancevski, I.; Nukui ,Y.; Hayakawa, S.; Chrousos, G.P.; Michos, A.; Tatsi ,E.B.; Filippatos, F.; Rodriguez-Palmero, A.; Troya, J.; Tipu, I.; Meyts, I.; Roussel, L.; Ostrowski, S.R.; Schidlowski,L.; Prando, C.; Condino-Neto, A.; Cheikh, N.; Bousfiha, A.A.; Bakkouri, J.E.; Peterson, P.; Pujol, A.; Lévy, R.; Quartier, P.; Vinh, D.C.; Boisson, B.; Béziat, V.; Zhang, S.Y.; Borghesi, A.; Pession, A.; Andreakos, E.; Marr, N.; Mentis, A.F.A.; H.mogensen, T.; Rodríguez-Gallego, C.; Soler-Palacin, P.; Colobran, R.; Tillmann, V.; Neven, B.; Trouillet-Assant, S.; Brodin, P.; Abel, L.; Jouanguy, E.; Zhang, Q.; Martinón-Torres, F.; Salas, A.; Gómez-Carballa, A.; Gonzalez-Granado, L.I.; Kisand, K.; Okada, S.; Puel, A.; Cobat, A.; Casanova, J.L.; Aguilera-Albesa, S.; Alkhater, S.A.; Alkan, G.; Castagnoli, R.; Cyrus, C.; Bozdemir, S.E.; Emiroglu, M.; Gulhan, B.; Erdeniz, E.H.; Hatipoglu, N.; Bayhan,G.I.; Jabandziev, P.; Yuksek, S.K. |
| Contributors: |
Tıp Fakültesi; Tıbbi Genetik Ana Bilim Dalı; TEMEL, ŞEHİME GÜLSÜN |
| Publisher Information: |
Rockefeller University Press |
| Publication Year: |
2025 |
| Collection: |
Açık Erişim@BUU (Bursa Uludağ Üniversitesi) |
| Subject Terms: |
Innate immunity and inflammation; Infectious disease and host defense; Immunodeficiency; COVID-19; SARS Coronavirus; Interferon Type I |
| Description: |
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plus IFN-β in two; IFN-ω only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-α2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-ω in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-α2 only (OR [95% CI] = 67.6 [5.7–9,196.6]) than for auto-Abs neutralizing IFN-ω only (OR [95% CI] = 2.6 [1.2–5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6–35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1–9.6]) of IFN-ω and/or IFN-α2. ; Square Foundation ; Battersea & Bowery Advisory Group ; BGI Genomics ; Institut National de la Santé et de la Recherche Médicale ; ANR AAILC ; Knut och Alice Wallenbergs Stiftelse ; General Atlantic Foundation ; Australasian Centre for Italian Studies ; Fonds de Recherche du Québec - Santé ; Generalitat de Catalunya ; Fondation Bettencourt Schueller ; BI-BACVIR ; Fondation du Souffle ; CovidPhy ; St. Giles Foundation ; Fonds Wetenschappelijk Onderzoek ; Fisher Center for Alzheimer's Research Foundation ; ELIDEK ; European Commission ; Merck Canada ; Agencia Estatal de Investigación ; Rockefeller University ; JPB Foundation ; University of Paris Cité and Imagine Institute ; Stavros Niarchos Foundation Institute for Global Infectious Disease Research ; Glenn Foundation for Medical Research ; Fondation Meyer pour le Développement Culturel et Artistique ; Vetenskapsrådet ; Howard Hughes Medical Institute ; Ministry of Education, Culture, Sports, Science and ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
Journal of Experimental Medicine; https://hdl.handle.net/11452/51420; 221 |
| DOI: |
10.1084/jem.20231353 |
| Availability: |
https://hdl.handle.net/11452/51420; https://doi.org/10.1084/jem.20231353 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.F954F33F |
| Database: |
BASE |