| Title: |
Circulating Citrate is Elevated During Profound Hypothyroidism:An Observational Study |
| Authors: |
Li, Yakun; Links, Mirthe H.; Post, Adrian; Connelly, Margery A.; Links, Thera P.; Dullaart, Robin P.F. |
| Source: |
Li, Y, Links, M H, Post, A, Connelly, M A, Links, T P & Dullaart, R P F 2025, 'Circulating Citrate is Elevated During Profound Hypothyroidism : An Observational Study', Metabolic syndrome and related disorders, vol. 23, no. 7, pp. 366-370. https://doi.org/10.1089/met.2025.0026 |
| Publication Year: |
2025 |
| Collection: |
University of Groningen research database |
| Subject Terms: |
circulating citrate; differentiated thyroid carcinoma; hypothyroidism; ketone bodies; mitochondrial dysfunction; nuclear magnetic resonance spectroscopy; thyroid stimulating hormone |
| Description: |
Purpose: We conducted an observational study on how profound hypothyroidism affects circulating citrate, a potential biomarker of mitochondrial dysfunction linked to mortality. Methods: Sixteen differentiated thyroid carcinoma patients were first studied during hypothyroidism, i.e., 4-6 weeks after total thyroidectomy, and subsequently after 20 weeks of thyroid hormone supplementation. 5 patients were also studied during euthyroidism, i.e., before total thyroidectomy. Circulating citrate and total ketone bodies were measured by nuclear magnetic resonance spectroscopy. Results: During profound hypothyroidism (mean thyroid stimulating hormone [TSH] 106 ± 77 mU/L), circulating citrate was 72% higher (95% CI: 48%-96%), reaching 157 ± 48 µmol/L, compared to 93 ± 25 µmol/L during thyroid hormone administration (mean TSH 0.20 ± 0.53 mU/L). This increase remained significant after adjusting for estimated glomerular filtration rate (eGFR) (P < 0.001) and body mass index (BMI) (P < 0.001). Citrate during hypothyroidism was also higher compared to five euthyroid patients studied before total thyroidectomy (P = 0.014). Total ketone bodies did not significantly change during hypothyroidism (P = 0.62). Conclusion: Short-term profound hypothyroidism gives rise to a major increase in circulating citrate, also when adjusted for changes in eGFR and BMI, conceivably attributable to hypothyroidism-related mitochondrial dysfunction. It is suggested that thyroid function status should be taken into consideration when evaluating the association of circulating citrate with adverse health outcomes. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
1540-4196 |
| Relation: |
info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/11370/41de6dfc-9f64-489c-9f1c-3a20d60db50f; info:eu-repo/semantics/altIdentifier/pissn/1540-4196 |
| DOI: |
10.1089/met.2025.0026 |
| Availability: |
https://hdl.handle.net/11370/41de6dfc-9f64-489c-9f1c-3a20d60db50f; https://research.rug.nl/en/publications/41de6dfc-9f64-489c-9f1c-3a20d60db50f; https://doi.org/10.1089/met.2025.0026; https://pure.rug.nl/ws/files/1419859966/Circulating_Citrate_is_Elevated_During_Profound_Hypothyroidism_An_Observational_Study.pdf; https://www.scopus.com/pages/publications/105008583325 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.F99E861F |
| Database: |
BASE |