| Title: |
Playing the devil’s advocate: Should we give a second chance to mTOR inhibition in renal clear cell carcinoma? – ie strategies to revert resistance to mtor inhibitors |
| Authors: |
Pezzicoli G.; Filoni E.; Gernone A.; Cosmai L.; Rizzo M.; Porta C. |
| Contributors: |
Pezzicoli, G.; Filoni, E.; Gernone, A.; Cosmai, L.; Rizzo, M.; Porta, C. |
| Publication Year: |
2021 |
| Collection: |
Università degli Studi di Bari Aldo Moro: CINECA IRIS |
| Subject Terms: |
Anti-angiogenic; Autophagy; Everolimu; Rapa-Link; Temsirolimus |
| Description: |
In the last decade, the inhibition of the mechanistic target of Rapamycin (mTOR) in renal clear cell carcinoma (RCC) has disappointed the clinician’s expectations. Many clinical trials highlighted the low efficacy and unmanageable safety profile of first-generation mTOR inhibitors (Rapalogs), thus limiting their use in the clinical practice only to those patients who already failed several therapy lines. In this review, we analyze the major resistance mechanisms that undermine the efficacy of this class of drugs. Moreover, we describe some of the possible strategies to overcome the mechanisms of resistance and their clinical experimentation, with particular focus on novel mTOR inhibitors and the combina-tions of mTOR inhibitors and other anti-cancer drugs. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/34675658; info:eu-repo/semantics/altIdentifier/wos/WOS:000705483400002; volume:13; firstpage:7623; lastpage:7636; numberofpages:14; journal:CANCER MANAGEMENT AND RESEARCH; https://hdl.handle.net/11586/389081 |
| DOI: |
10.2147/CMAR.S267220 |
| Availability: |
https://hdl.handle.net/11586/389081; https://doi.org/10.2147/CMAR.S267220; https://www.dovepress.com/playing-the-devils-advocate-should-we-give-a-second-chance-to-mtor-inh-peer-reviewed-fulltext-article-CMAR |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.FA105939 |
| Database: |
BASE |