| Title: |
Severe hypercalcaemia due to subcutaneous fat necrosis: presentation, management and complications |
| Authors: |
Shumer, Daniel E; Thaker, Vidhu; Taylor, George A; Wassner, Ari J |
| Publisher Information: |
BMJ Publishing Group Ltd |
| Publication Year: |
2014 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Original articles |
| Description: |
Objective Subcutaneous fat necrosis (SCFN) is a rare form of panniculitis in infants that generally occurs following birth trauma, meconium aspiration, or therapeutic cooling. Severe hypercalcaemia occurs in a subset of patients, but data on its presentation, management and outcomes are limited. This report details the clinical course and complications of infants treated for severe hypercalcaemia (peak serum calcium ≥3.0 mmol/L) due to SCFN. Design Chart review of all infants with SCFN seen at a single paediatric centre over a 13-year period. Patients Seven infants with SCFN developed severe hypercalcaemia, with median peak serum calcium 4.1 mmol/L (range 3.3–5.1). Results Severe hypercalcaemia occurred before 6 weeks of age, and was asymptomatic in 3/7 patients (43%). Most patients were treated with intravenous hydration, furosemide, glucocorticoids and low-calcium formula, which restored normocalcaemia in a median of 9 days (range 2–42). Fever developed during treatment in 4/7 infants (57%): two patients had bacterial infections and two had no infectious source identified. Nephrocalcinosis was present in 5/6 patients (83%) who were evaluated by renal ultrasound. Nephrocalcinosis failed to resolve in all cases over a median follow-up of 20 months (range 8–48), but no renal dysfunction was observed. Eosinophilia, which has not been reported previously in SCFN, was present in 6/7 patients (86%). Conclusions In this largest series to date of infants with severe hypercalcaemia due to SCFN, novel findings include the common occurrence of fever and a high incidence of persistent nephrocalcinosis without evidence of adverse renal outcomes. |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://fn.bmj.com/cgi/content/short/99/5/F419; http://dx.doi.org/10.1136/archdischild-2014-306069 |
| DOI: |
10.1136/archdischild-2014-306069 |
| Availability: |
http://fn.bmj.com/cgi/content/short/99/5/F419; https://doi.org/10.1136/archdischild-2014-306069 |
| Rights: |
Copyright (C) 2014, BMJ Publishing Group |
| Accession Number: |
edsbas.FA12C1B6 |
| Database: |
BASE |