| Title: |
Fixation using alternative implants for the treatment of hip fractures (FAITH): design and rationale for a multi-centre randomized trial comparing sliding hip screws and cancellous screws. |
| Authors: |
McCormack, Robert; Apostle, Kelly; Boyer, Dory; Moola, Farhad; Perey, Bertrand; Stone, Trevor; Viskontas, Darius; Lemke, H Michael; Zomar, Mauri; Moon, Karyn; Moon, Raely; Oatt, Amber; Buckley, Richard E; Duffy, Paul; Korley, Robert; Puloski, Shannon; Johnston, Kelly; Powell, James; Carcary, Kimberly; Sanders, David; Lawendy, Abdel; Tieszer, Christina; Stephen, David; Kreder, Hans; Jenkinson, Richard; Nousiainen, Markku; Axelrod, Terry; Murnaghan, John; Nam, Diane; Wadey, Veronica; Yee, Albert; Milner, Katrine; Kunz, Monica; Schemitsch, Emil H; Ahn, Henry; Hall, Jeremy A; McKee, Michael D; Whelan, Daniel B; Nauth, Aaron; Vicente, Milena R; Wild, Lisa M; Khan, Ryan M; Hidy, Jennifer T; Coles, Chad; Leighton, Ross; Biddulph, Michael; Johnston, David; Glazebrook, Mark; Alexander, David; Coady, Cathy; Dunbar, Michael; Amirault, David; Gross, Michael; Oxner, William; Reardon, Gerald; Richardson, Glen; Trenholm, Andrew; Wong, Ivan; Trask, Kelly; MacDonald, Shelley; Dobbin, Gwen; Bicknell, Ryan; Yach, Jeff; Bardana, Davide; Wood, Gavin; Harrison, Mark; Yen, David; Lambert, Sue; Howells, Fiona; Ward, Angela; Zalzal, Paul; Brien, Heather; Naumetz, V; Weening, Brad; Simunovic, Nicole; Wai, Eugene K; Papp, Steve; Gofton, Wade T; Liew, Allen; Kingwell, Stephen P; Johnson, Garth; O'Neil, Joseph; Roffey, Darren M; Borsella, Vivian; Avram, Victoria; Oliver, Todd M; Jones, Vicki; Jones, Clifford B; Ringler, James R; Endres, Terrence J; Sietsema, Debra L; Jeray, Kyle J; Broderick, J Scott; Goetz, David R; Pace, Thomas B; Schaller, Thomas M; Porter, Scott E; Tanner, Stephanie L; Snider, Rebecca G; Nastoff, Lauren A; Bielby, Shea A; Switzer, Julie A; Cole, Peter A; Anderson, Sarah A; Lafferty, Paul M; Li, Mengnai; Ly, Thuan V; Marston, Scott B; Foley, Amy L; Vang, Sandy; Wright, David M; Marcantonio, Andrew J; Kain, Michael SH; Iorio, Richard; Specht, Lawrence M; Tilzey, John F; Lobo, Margaret J; Garfi, John S; Vallier, Heather A; Dolenc, Andrea; Robinson, Chalitha; Prayson, Michael J; Laughlin, Richard; Rubino, L Joseph; May, Jedediah; Rieser, Geoffrey Ryan; Dulaney-Cripe, Liz; Gayton, Chris; Shaer, James; Schrickel, Tyson; Hileman, Barbara; Gorczyca, John T; Gross, Jonathan M; Humphrey, Catherine A; Kates, Stephen; Noble, Krista; McIntyre, Allison W; Pecorella, Kaili; Davis, Craig A; Weinerman, Stewart; Weingarten, Peter; Stull, Philip; Lindenbaum, Stephen; Hewitt, Michael; Schwappach, John; Baker, Janell K; Rutherford, Tori; Newman, Heike; Lieberman, Shane; Finn, Erin; Robbins, Kristin; Hurley, Meghan; Lyle, Lindsey; Mitchell, Khalis; Browner, Kieran; Whatley, Erica; Payton, Krystal; Reeves, Christina; Cannada, Lisa K; Karges, David; Hill, Leslie; Mehta, Samir; Esterhai, John; Ahn, Jaimo; Horan, Annamarie D; McGinnis, Kelly; Kaminski, Christine A; Kowalski, Brynn N; Keeve, Jonathan P; Anderson, Christopher G; McDonald, Michael D; Hoffman, Jodi M; Tarkin, Ivan; Siska, Peter; Gruen, Gary; Evans, Andrew; Farrell, Dana J; Irrgang, James; Luther, Arlene; Cross, William W; Cass, Joseph R; Sems, Stephen A; Torchia, Michael E; Scrabeck, Tyson; Jenkins, Mark; Dumais, Jules; Romero, Amanda W; Sagebien, Carlos A; Butler, Mark S; Monica, James T; Seuffert, Patricia; Hsu, Joseph R; Ficke, James; Charlton, Michael; Napierala, Matthew; Fan, Mary; Tornetta, Paul; Tannoury, Chadi; Carlisle, Hope; Silva, Heather; Archdeacon, Michael; Finnan, Ryan; Le, Toan; Wyrick, John; Hess, Shelley; Brennan, Michael L; Probe, Robert; Kile, Evelyn; Mills, Kelli; Clipper, Lydia; Yu, Michelle; Erwin, Katie; Horwitz, Daniel; Strohecker, Kent; Swenson, Teresa K; Aurang, Kamran; Zohman, Gary; Peterson, Brett; Huff, Roger B; Baele, Joseph; Weber, Timothy; Edison, Matt; McBeth, Jessica; Shively, Karl; Ertl, Janos P; Mullis, Brian; Parr, J Andrew; Worman, Ripley; Frizzell, Valda; Moore, Molly M; Tobias, Erin; Thomas, Emily; DePaolo, Charles J; Alosky, Rachel; Shell, Leslie E; Hampton, Lynne; Shepard, Stephanie; Nanney, Tracy; Cuento, Claudine; Cantu, Robert V; Henderson, Eric R; Eickhoff, Linda S; Hammerberg, E Mark; Stahel, Philip; Hak, David; Mauffrey, Cyril; Gibula, Douglas; Gissel, Hannah; Henderson, Corey; Zamorano, David P; Tynan, Martin C; Pourmand, Deeba; Lawson, Deanna; Della Rocca, Gregory J; Crist, Brett D; Murtha, Yvonne M; Anderson, Linda K; Linehan, Colleen; Pilling, Lindsey; Lewis, Courtland G; Caminiti, Stephanie; Sullivan, Raymond J; Roper, Elizabeth; Obremskey, William; Kregor, Philip; Richards, Justin E; Stringfellow, Kenya; Dohm, Michael P; Zellar, Abby; Segers, Michiel JM; Zijl, Jacco AC; Verhoeven, Bart; Smits, Anke B; de Vries, Jean Paul PM; Fioole, Bram; van der Hoeven, Henk; Theunissen, Evert BM; Reilingh, Tammo S de Vries; Govaert, Lonneke; Wittich, Philippe; de Brauw, Maurits; Wille, Jan; Go, Peter MNYM; Ritchie, Ewan D; Wessel, Ronald N; Hammacher, Eric R; Heetveld, Martin J; Visser, Gijs A; Stockmann, Heyn; Silvis, Rob; Snellen, Jaap P; Rijbroek, Bram; Scheepers, Joris JG; Vermeulen, Erik GJ; Siroen, Michiel PC; Vuylsteke, Ronald; Brom, Hans LF; Rijna, Herman; de Rijcke, Piet AR; Koppert, Cees L; Buijk, Steven E; Groenendijk, Richard PR; Dawson, Imro; Tetteroo, Geert WM; Bruijninckx, Milko MM; Doornebosch, Pascal G; de Graaf, Eelco JR; van der Elst, Maarten; van der Pol, Carmen C; van 't Riet, Martijne; Karsten, Tom M; de Vries, Mark R; Stassen, Laurents PS; Schep, Niels WL; Ben Schmidt, G; Hoffman, WH; Poolman, Rudolf W; Simons, Maarten P; van der Heijden, Frank HWM; Willems, W Jaap; de Meulemeester, Frank RAJ; van der Hart, Cor P; Turckan, Kahn; Festen, Sebastiaan; de Nies, Frank; Haverlag, Robert; Out, Nico JM; Bosma, Jan; van Kampen, Albert; Biert, Jan; van Vugt, Arie B; Edwards, Michael JR; Blokhuis, Taco J; Frolke, Jan Paul M; Geeraedts, Leo MG; Gardeniers, Jean WM; Tan, Edward TCH; Poelhekke, Lodewijk MSJ; Malefijt, Maarten C de Waal; Schreurs, Bart; Roukema, Gert R; Josaputra, Hong A; Keller, Paul; de Rooij, Peter D; Kuiken, Hans; Boxma, Han; Cleffken, Berry I; Liem, Ronald; Rhemrev, Steven J; Bosman, Coks HR; van Otterloo, Alexander de Mol; Hoogendoorn, Jochem; de Vries, Alexander C; Meylaerts, Sven AG; Verhofstad, Michiel HJ; Meijer, Joost; van Egmond, Teun; van der Brand, Igor; Patka, Peter; Eversdijk, Martin G; Peters, Rolf; Den Hartog, Dennis; Van Waes, Oscar JF; Oprel, Pim; van der Vis, Harm M; Campo, Martin; Verhagen, Ronald; Albers, GH Robert; Zurcher, Arthur W; Simmermacher, Rogier KJ; van Mulken, Jeroen; van Wessem, Karlijn; van Gaalen, Steven M; Leenen, Luke PH; Bronkhorst, Maarten WGA; Guicherit, Onno R; Goslings, J Carel; Ponsen, Kees Jan; Bhatia, Mahesh; Arora, Vinod; Tyagi, Vivek; Liew, Susan; Bedi, Harvinder; Carr, Ashley; Curry, Hamish; Chia, Andrew; Csongvay, Steve; Donohue, Craig; Doig, Stephen; Edwards, Elton; Etherington, Greg; Esser, Max; Gong, Andrew; Jain, Arvind; Li, Doug; Miller, Russell; Moaveni, Ash; Russ, Matthias; Ton, Lu; Wang, Otis; Dowrick, Adam; Murdoch, Zoe; Sage, Claire; Frihagen, Frede; Clarke-Jenssen, John; Hjorthaug, Geir; Ianssen, Torben; Amundsen, Asgeir; Brattgjerd, Jan Egil; Borch, Tor; Boe, Berthe; Flatoy, Bernhard; Hasselund, Sondre; Haug, Knut Jorgen; Hemlock, Kim; Hoseth, Tor Magne; Jomaas, Geir; Kibsgard, Thomas; Lona, Tarjei; Moatshe, Gilbert; Muller, Oliver; Molund, Marius; Nicolaisen, Tor; Nilsen, Fredrik; Rydinge, Jonas; Smedsrud, Morten; Stodle, Are; Trommer, Axel; Ugland, Stein; Karlsten, Anders; Ekas, Guri; Vesterhus, Elise Berg; Brekke, Anne Christine; Gupta, Ajay; Jain, Neeraj; Khan, Farah; Sharma, Ateet; Sanghavi, Amir; Trivedi, Mittal; Rai, Anil; Subash; Rai, Kamal; Yadav, Vineet; Singh, Sanjay; Tetsworth, Kevin; Donald, Geoff; Weinrauch, Patrick; Pincus, Paul; Yang, Steven; Halliday, Brett; Gervais, Trevor; Holt, Michael; Flynn, Annette; Prasad, Amal Shankar; Mishra, Vimlesh; Sundaresh, DC; Khanna, Angshuman; Cherian, Joe Joseph; Olakkengil, Davy J; Sharma, Gaurav; Pirpiris, Marinis; Love, David; Bucknill, Andrew; Farrugia, Richard J; Pape, Hans-Christoph; Knobe, Matthias; Pfeifer, Roman; Hull, Peter; Lewis, Sophie; Evans, Simone; Nanda, Rajesh; Logishetty, Rajanikanth; Anand, Sanjeev; Bowler, Carol; Dadi, Akhil; Palla, Naveen; Ganguly, Utsav; Rai, B Sachidananda; Rajakumar, Janakiraman; Jennings, Andrew; Chuter, Graham; Rose, Glynis; Horner, Gillian; Clark, Callum; Eke, Kate; Reed, Mike; Herriott, Chris; Dobb, Christine; Bhandari, Mohit; Swiontkowski, Marc; Devereaux, Pj; Jeray, Kyle; Thabane, Lehana; Walter, Stephen; Sprague, Sheila; Scott, Taryn; Guyatt, Gordon; Viveiros, Helena; McKay, Paula; Swinton, Marilyn; Truong, Victoria; Koo, Kaitlin; Heels-Ansdell, Diane; Zhou, Qi; Buckingham, Lisa; Duraikannan, Aravin; Maddock, Deborah; Agel, Julie; Van Lieshout, Esther MM; Zielinski, Stephanie M; Rangan, Amar; Hanusch, Birgit C; Kottam, Lucksy; Clarkson, Rachel; Slobogean, Gerard; Katz, Jeffrey; Gillespie, Brenda; Greendale, Gail A; Guy, Pierre; Hartman, Curtis; Rubin, Craig; Waddell, James |
| Publisher Information: |
BioMed Central |
| Publication Year: |
2014 |
| Collection: |
Griffith University: Griffith Research Online |
| Subject Terms: |
Clinical sciences |
| Description: |
Background Hip fractures are a common type of fragility fracture that afflict 293,000 Americans (over 5,000 per week) and 35,000 Canadians (over 670 per week) annually. Despite the large population impact the optimal fixation technique for low energy femoral neck fractures remains controversial. The primary objective of the FAITH study is to assess the impact of cancellous screw fixation versus sliding hip screws on rates of revision surgery at 24 months in individuals with femoral neck fractures. The secondary objective is to determine the impact on health-related quality of life, functional outcomes, health state utilities, fracture healing, mortality and fracture-related adverse events. Methods/Design FAITH is a multi-centre, multi-national randomized controlled trial utilizing minimization to determine patient allocation. Surgeons in North America, Europe, Australia, and Asia will recruit a total of at least 1,000 patients with low-energy femoral neck fractures. Using central randomization, patients will be allocated to receive surgical treatment with cancellous screws or a sliding hip screw. Patient outcomes will be assessed at one week (baseline), 10 weeks, 6, 12, 18, and 24 months post initial fixation. We will independently adjudicate revision surgery and complications within 24 months of the initial fixation. Outcome analysis will be performed using a Cox proportional hazards model and likelihood ratio test. Discussion This study represents major international efforts to definitively resolve the treatment of low-energy femoral neck fractures. This trial will not only change current Orthopaedic practice, but will also set a benchmark for the conduct of future Orthopaedic trials. ; Full Text |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
BMC Musculoskeletal Disorders; https://hdl.handle.net/10072/66463 |
| DOI: |
10.1186/1471-2474-15-219 |
| Availability: |
https://hdl.handle.net/10072/66463; https://doi.org/10.1186/1471-2474-15-219 |
| Rights: |
http://creativecommons.org/licenses/by/2.0 ; © 2014 The FAITH Investigators; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ; open access |
| Accession Number: |
edsbas.FA223209 |
| Database: |
BASE |