| Title: |
NT-proBNP response to dobutamine stress echocardiography predicts left ventricular contractile reserve in dilated cardiomyopathy |
| Authors: |
Parthenakis, Frangiskos I.; Patrianakos, Alexandros P.; Haritakis, Costas N.; Zacharis, Evangelos A.; Nyktari, Eva G.; Vardas, Panos E. |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2008 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Natriuretic Peptides |
| Description: |
Background: Brain natriuretic peptide (BNP) and left ventricular (LV) inotropic reserve are major prognostic indexes in heart failure (HF). Aims: To investigate the relationship between N-terminal-proBNP (NT-proBNP) changes in response to dobutamine stress echocardiography (DSE) and the LV inotropic reserve, in HF patients with dilated cardiomyopathy (DC). Methods: We studied 41 patients with DC, LVEF 31.6±7.7%, NYHA class II–III and 15 controls. Plasma NT-proBNP levels were measured before and 60 min after three 5-min stages of dobutamine (5 to 15μg/kg/min). Results: Based on NT-proBNP changes in response to dobutamine, patients were categorized into two groups: In Group A circulating NT-proBNP levels fell (−16.6 ± 7.8%), and in Group B they increased (8.4±9.1%). Group A had a marked improvement in WMSI compared to Group B (32.1±9.7% vs. 18.8±15.9%, p |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://eurjhf.oxfordjournals.org/cgi/content/short/10/5/475; http://dx.doi.org/10.1016/j.ejheart.2008.03.003 |
| DOI: |
10.1016/j.ejheart.2008.03.003 |
| Availability: |
http://eurjhf.oxfordjournals.org/cgi/content/short/10/5/475; https://doi.org/10.1016/j.ejheart.2008.03.003 |
| Rights: |
Copyright (C) 2008, European Society of Cardiology |
| Accession Number: |
edsbas.FA58644D |
| Database: |
BASE |