| Title: |
Recruitment and Expansion of Tregs Cells in the Tumor Environment—How to Target Them? |
| Authors: |
Cinier, Justine; Hubert, Margaux; Besson, Laurie; Di Roio, Anthony; Rodriguez, Céline; Lombardi, Vincent; Caux, Christophe; Ménétrier-Caux, Christine |
| Contributors: |
Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL); Centre Léon Bérard Lyon -Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Institut de Recherches SERVIER (IRS); ANR-10-LABX-0061,DEVWECAN,Development Cancer and Targeted Therapies(2010); ANR-11-IDEX-0007,Avenir L.S.E.,PROJET AVENIR LYON SAINT-ETIENNE(2011) |
| Source: |
ISSN: 2072-6694. |
| Publisher Information: |
CCSD; MDPI |
| Publication Year: |
2021 |
| Collection: |
Université de Lyon: HAL |
| Subject Terms: |
regulatory T cells; tumor microenvironment; recruitment; proliferation; stability; therapeutic targeting; [SDV.CAN]Life Sciences [q-bio]/Cancer; [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology; [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy |
| Description: |
International audience ; Regulatory T cells (Tregs) are present in a large majority of solid tumors and are mainly associated with a poor prognosis, as their major function is to inhibit the antitumor immune response contributing to immunosuppression. In this review, we will investigate the mechanisms involved in the recruitment, amplification and stability of Tregs in the tumor microenvironment (TME). We will also review the strategies currently developed to inhibit Tregs’ deleterious impact in the TME by either inhibiting their recruitment, blocking their expansion, favoring their plastic transformation into other CD4+ T-cell subsets, blocking their suppressive function or depleting them specifically in the TME to avoid severe deleterious effects associated with Treg neutralization/depletion in the periphery and normal tissues. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.3390/cancers13081850 |
| Availability: |
https://hal.science/hal-03769664; https://hal.science/hal-03769664v1/document; https://hal.science/hal-03769664v1/file/cancers-13-01850-v2.pdf; https://doi.org/10.3390/cancers13081850 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.FA81932A |
| Database: |
BASE |