Do demographic and clinical features and comorbidities affect the risk of spread to an additional body site in functional motor disorders?
| Title: | Do demographic and clinical features and comorbidities affect the risk of spread to an additional body site in functional motor disorders? |
|---|---|
| Authors: | Ercoli T; Tinazzi M; Geroin C; Marcuzzo E; Erro R; Cuoco S; Ceravolo R; Mazzucchi S; Pilotto A; Padovani A; Romito LM; Eleopra R; Zappia M; Nicoletti A; Dallocchio C; Arbasino C; Bono F; Spano G; Demartini B; Gambini O; Modugno N; Olivola E; Bonanni L; Albanese A; Ferrazzano G; Tessitore A; Lopiano L; Calandra-Buonaura G; Petracca M; Morgante F; Esposito M; Pisani A; Manganotti P; Tesolin L; Teatini F; Stocchi F; Defazio G. |
| Contributors: | Ercoli, T; Tinazzi, M; Geroin, C; Marcuzzo, E; Erro, R; Cuoco, S; Ceravolo, R; Mazzucchi, S; Pilotto, A; Padovani, A; Romito, Lm; Eleopra, R; Zappia, M; Nicoletti, A; Dallocchio, C; Arbasino, C; Bono, F; Spano, G; Demartini, B; Gambini, O; Modugno, N; Olivola, E; Bonanni, L; Albanese, A; Ferrazzano, G; Tessitore, A; Lopiano, L; Calandra-Buonaura, G; Petracca, M; Morgante, F; Esposito, M; Pisani, A; Manganotti, P; Tesolin, L; Teatini, F; Stocchi, F; Defazio, G. |
| Publication Year: | 2022 |
| Collection: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| Subject Terms: | Functional motor disorders; Functional neurological disorders; Outcome; Phenotypic change; Spread |
| Description: | The aim of this study isto assess changes in the body distribution and the semeiology of functional motor disorder (FMD) in patients who reported only one or more than one body site affected at FMD onset. Data were obtained from the Italian Registry of Functional Motor Disorders, which included patients with a diagnosis of clinically definite FMDs. The relationship between FMD features and spread to other body sites was estimated by multivariate Cox regression analysis. We identified 201 (49%) patients who reported only one body site affected at FMD onset and 209 (51%) who reported multiple body sites affected at onset. FMD spread from the initial site to another site in 43/201 (21.4%) patients over 5.7 ± 7.1years in those with only one site affected at FMD onset; FMD spread to an another body site in 29/209 (13.8%) over 5.5 ± 6.5years. The spread of FMD was associated with non-motor functional symptoms and psychiatric comorbidities only in the patients with one body site affected at FMD onset. Our findings provide novel insight into the natural history of FMD. The number of body sites affected at onset does not seem to have a consistent influence on the risk of spread. Furthermore, our findings suggest that psychiatric comorbidities and non-motor functional symptoms may predict the spread of FMD symptoms, at least in patients with one body site affected at onset. |
| Document Type: | article in journal/newspaper |
| File Description: | STAMPA |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/35972697; info:eu-repo/semantics/altIdentifier/wos/WOS:000841060900001; volume:129; issue:10; firstpage:1271; lastpage:1276; numberofpages:6; journal:JOURNAL OF NEURAL TRANSMISSION; https://hdl.handle.net/11562/1073648 |
| DOI: | 10.1007/s00702-022-02537-x |
| Availability: | https://hdl.handle.net/11562/1073648; https://doi.org/10.1007/s00702-022-02537-x |
| Rights: | info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.FA9810FA |
| Database: | BASE |