| Title: |
Analysis of SARS-CoV-2 synonymous codon usage evolution throughout the COVID-19 pandemic |
| Authors: |
Mogro, Ezequiel Gerardo; Bottero, Daniela; Lozano, Mauricio Javier |
| Publication Year: |
2022 |
| Collection: |
Universidad Nacional de La Plata (UNLP): SeDiCI (Servicio de Difusión de la Creación Intelectual) |
| Subject Terms: |
Biología; Codon usage bias; SARS-CoV-2; COVID-19; Betacoronavirus |
| Description: |
SARS-CoV-2, the seventh coronavirus known to infect humans, can cause severe life-threatening respiratory pathologies. To better understand SARS-CoV-2 evolution, genome-wide analyses have been made, including the general characterization of its codons usage profile. Here we present a bioinformatic analysis of the evolution of SARS-CoV-2 codon usage over time using complete genomes collected since December 2019. Our results show that SARS-CoV-2 codon usage pattern is antagonistic to, and it is getting farther away from that of the human host. Further, a selection of deoptimized codons over time, which was accompanied by a decrease in both the codon adaptation index and the effective number of codons, was observed. All together, these findings suggest that SARS-CoV-2 could be evolving, at least from the perspective of the synonymous codon usage, to become less pathogenic. ; Instituto de Biotecnología y Biología Molecular |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
http://sedici.unlp.edu.ar/handle/10915/159865 |
| Availability: |
http://sedici.unlp.edu.ar/handle/10915/159865 |
| Rights: |
http://creativecommons.org/licenses/by-nc-sa/4.0/ ; Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
| Accession Number: |
edsbas.FAAAF974 |
| Database: |
BASE |