| Title: |
Anti-protein C antibodies and acquired protein C resistance in SLE: novel markers for thromboembolic events and disease activity? |
| Authors: |
Ramirez, GA; Mackie, I; Nallamilli, S; Pires, T; Moll, R; Pericleous, C; Isenberg, DA; Cohen, H; Efthymiou, M |
| Source: |
Rheumatology , 60 (3) pp. 1376-1386. (2021) |
| Publication Year: |
2021 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
activated protein C resistance; anti-protein C antibodies; antiphospholipid antibodies; systemic lupus erythematosus; thrombosis |
| Description: |
OBJECTIVES: Risk factors for thromboembolism in SLE are poorly understood. We hypothesized a possible role for protein C, based on its dual activity in inflammation and haemostasis and on the evidence of an association between acquired activated protein C (APC) resistance (APCR) and high-avidity anti-protein C antibodies (anti-PC) with a severe thrombotic phenotype in venous thrombosis APS patients. METHODS: In a cross-sectional study of 156 SLE patients, the presence and avidity of IgG anti-PC was established by in house-ELISA, and APCR to exogenous recombinant human APC (rhAPC) and Protac (which activates endogenous protein C) was assessed by thrombin generation-based assays. Associations with aPL profile, thrombotic history and disease activity (BILAG and SLEDAI-2K) were also established. RESULTS: Anti-PC were detected in 54.5% of patients and APCR in 59%. Anti-PC positivity was associated with APCR to both rhAPC (P |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10110831/1/Manuscript_aPC_SLE.pdf; https://discovery.ucl.ac.uk/id/eprint/10110831/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10110831/1/Manuscript_aPC_SLE.pdf; https://discovery.ucl.ac.uk/id/eprint/10110831/ |
| Rights: |
open |
| Accession Number: |
edsbas.FAD87F53 |
| Database: |
BASE |