| Title: |
CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth |
| Authors: |
Griffith, Gina L.; Machmach, Kawthar; Jian, Ningbo; Kim, Dohoon; Costanzo, Margaret C.; Creegan, Matthew; Swafford, Isabella; Kundu, Gautam; Yum, Lauren; Bolton, Jessica S.; Smith, Lauren; Slike, Bonnie M.; Bergmann-Leitner, Elke S.; Thomas, Rasmi; Michael, Nelson L.; Ake, Julie A.; Eller, Leigh Anne; Robb, Merlin L.; Townsley, Samantha M.; Krebs, Shelly J.; Paquin-Proulx, Dominic |
| Contributors: |
Reeves, R. Keith; U.S. Department of Defense; Division of Intramural Research, National Institute of Allergy and Infectious Diseases |
| Source: |
PLOS Pathogens ; volume 21, issue 1, page e1012916 ; ISSN 1553-7374 |
| Publisher Information: |
Public Library of Science (PLoS) |
| Publication Year: |
2025 |
| Collection: |
PLOS Publications (via CrossRef) |
| Description: |
New HIV vaccine approaches are focused on eliciting broadly neutralizing antibodies. We characterized early gamma-delta (γδ) T cell responses starting from pre-acquisition and during acute HIV infection (AHI) in participants previously characterized for neutralization breadth development. We found significant differences in γδ T cell surface marker expression in participants that developed neutralization breadth compared to those that did not. Activation of γδ T cells occurred within the first weeks of HIV acquisition and associated with viral load. Expression of CD16 on Vδ1 T cells and CD57 on Vδ2 T cells were found to be significantly higher in broad neutralizers during AHI, and associated with the development of neutralization breadth years later. In addition, the levels of CD16 on Vδ1 T cells was associated with early production of founder virus Env-specific IgM. Thus, γδ T cells may promote development of neutralization breadth, which has implications for HIV vaccine strategies. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1371/journal.ppat.1012916 |
| Availability: |
https://doi.org/10.1371/journal.ppat.1012916; https://dx.plos.org/10.1371/journal.ppat.1012916 |
| Rights: |
https://creativecommons.org/publicdomain/zero/1.0/ |
| Accession Number: |
edsbas.FB116FE2 |
| Database: |
BASE |