| Title: |
Bradykinin Receptor Antagonism and Endothelial Tissue Plasminogen Activator Release in Humans |
| Authors: |
Witherow, Fraser N.; Dawson, Pamela; Ludlam, Christopher A.; Webb, David J.; Fox, Keith A.A.; Newby, David E. |
| Source: |
Arteriosclerosis, Thrombosis, and Vascular Biology ; volume 23, issue 9, page 1667-1670 ; ISSN 1079-5642 1524-4636 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2003 |
| Description: |
Objective— We sought to assess pharmacodynamic responses to the bradykinin antagonist B9340 and to determine the contribution of the endothelial bradykinin receptor to stimulated tissue plasminogen activator (t-PA) release in humans. Methods and Results— Bilateral forearm blood flow and plasma fibrinolytic variables were measured in 8 volunteers during 100 minutes of intrabrachial infusions of saline placebo, B9340 at 4.5 nmol/min, or B9340 at 13.5 nmol/min. On each occasion, intra-arterial bradykinin (30 to 3000 pmol/min) and substance P (4 to 16 pmol/min) were coinfused for 10 minutes at each dose. To assess the onset and offset of action, 6 additional subjects on 2 occasions received intra-arterial bradykinin (100 pmol/min) for 60 minutes with a coinfusion of either saline placebo or B9340 (13.5 nmol/min) for 12 minutes. During placebo infusion, bradykinin and substance P caused dose-dependent vasodilatation in the infused forearm ( P |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1161/01.atv.0000087142.99472.f6 |
| DOI: |
10.1161/01.ATV.0000087142.99472.F6 |
| Availability: |
https://doi.org/10.1161/01.atv.0000087142.99472.f6; https://www.ahajournals.org/doi/full/10.1161/01.ATV.0000087142.99472.F6 |
| Accession Number: |
edsbas.FB53CFAB |
| Database: |
BASE |