| Title: |
Right ventricular remodelling in pulmonary arterial hypertension predicts treatment response. |
| Authors: |
Goh, Z.M.; Balasubramanian, N.; Alabed, S.; Dwivedi, K.; Shahin, Y.; Rothman, A.M.K.; Garg, P.; Lawrie, A.; Capener, D.; Thompson, A.A.R.; Alandejani, F.; Wild, J.M.; Johns, C.S.; Lewis, R.A.; Gosling, R.; Sharkey, M.; Condliffe, R.; Kiely, D.G.; Swift, A.J. |
| Publisher Information: |
BMJ Publishing Group |
| Publication Year: |
2022 |
| Collection: |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
| Description: |
Objectives: To determine the prognostic value of patterns of right ventricular adaptation in patients with pulmonary arterial hypertension (PAH), assessed using cardiac magnetic resonance (CMR) imaging at baseline and follow-up. Methods: Patients attending the Sheffield Pulmonary Vascular Disease Unit with suspected pulmonary hypertension were recruited into the ASPIRE (Assessing the Spectrum of Pulmonary hypertension Identified at a REferral Centre) Registry. With exclusion of congenital heart disease, consecutive patients with PAH were followed up until the date of census or death. Right ventricular end-systolic volume index adjusted for age and sex and ventricular mass index were used to categorise patients into four different volume/mass groups: low-volume-low-mass, low-volume-high-mass, high-volume-low-mass and high-volume-high-mass. The prognostic value of the groups was assessed with one-way analysis of variance and Kaplan-Meier plots. Transition of the groups was studied. Results: A total of 505 patients with PAH were identified, 239 (47.3%) of whom have died at follow-up (median 4.85 years, IQR 4.05). The mean age of the patients was 59±16 and 161 (32.7%) were male. Low-volume-low-mass was associated with CMR and right heart catheterisation metrics predictive of improved prognosis. There were 124 patients who underwent follow-up CMR (median 1.11 years, IQR 0.78). At both baseline and follow-up, the high-volume-low-mass group had worse prognosis than the low-volume-low-mass group (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
1355-6037 |
| Relation: |
https://eprints.whiterose.ac.uk/id/eprint/186763/1/heartjnl-2021-320733.full.pdf; Goh, Z.M., Balasubramanian, N., Alabed, S. orcid.org/0000-0002-9960-7587 et al. (16 more authors) (2022) Right ventricular remodelling in pulmonary arterial hypertension predicts treatment response. Heart, 108. pp. 1392-1400. ISSN: 1355-6037 |
| Availability: |
https://eprints.whiterose.ac.uk/id/eprint/186763/ |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.FB656648 |
| Database: |
BASE |