| Title: |
Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia |
| Authors: |
Gonzalez, MC; Tovar-Rios, DA; Alves, G; Dalen, I; Williams-Gray, CH; Camacho, M; Forsgren, L; Bäckström, D; Lawson, RA; Macleod, AD; Counsell, CE; Paquet, C; DeLena, C; D'Antonio, F; Pilotto, A; Padovani, A; Blanc, F; Falup-Pecurariu, C; Lewis, SJG; Rejdak, K; Papuc, E; Hort, J; Nedelska, Z; O'Brien, J; Bonanni, L; Marquié, M; Boada, M; Pytel, V; Abdelnour, C; Alcolea, D; Beyer, K; Tysnes, OB; Aarsland, D; Maple-Grødem, J |
| Publisher Information: |
Wiley; //doi.org/10.1002/mdc3.13752 |
| Publication Year: |
2023 |
| Collection: |
Apollo - University of Cambridge Repository |
| Subject Terms: |
Parkinson's disease dementia; dementia with Lewy bodies; international cohort; parkinsonism; rate of cognitive decline |
| Description: |
Background: There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD). Objectives: To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E-DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts. Methods: The annual change in MMSE and MDS-UPDRS part III was estimated using linear mixed regression models in patients with at least one follow-up (DLB n = 837 and PDD n = 157). Results: When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (−1.8 [95% CI −2.3, −1.3] vs. −1.9 [95% CI −2.6, −1.2] [P = 0.74]). MDS-UPDRS part III showed nearly identical annual changes (DLB 4.8 [95% CI 2.1, 7.5]) (PDD 4.8 [95% CI 2.7, 6.9], [P = 0.98]). Conclusions: DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/msword; image/png |
| Language: |
English |
| Relation: |
https://www.repository.cam.ac.uk/handle/1810/350106 |
| Availability: |
https://www.repository.cam.ac.uk/handle/1810/350106 |
| Rights: |
All rights reserved ; http://purl.org/NET/rdflicense/allrightsreserved |
| Accession Number: |
edsbas.FB78F91B |
| Database: |
BASE |