THC on the brain: Adult vs. Adolescent Changes
| Title: | THC on the brain: Adult vs. Adolescent Changes |
|---|---|
| Authors: | Smartt, Addison; Edwards, Jeffrey, PhD |
| Source: | Library/Life Sciences Undergraduate Poster Competition 2023 |
| Publisher Information: | BYU ScholarsArchive |
| Publication Year: | 2023 |
| Collection: | Brigham Young University (BYU): ScholarsArchive |
| Subject Terms: | THC; neuroscience; PCR; synaptic plasticity; long term depression (LTD); Life Sciences |
| Description: | Δ9 -tetrahydrocannabinol (THC) has been demonstrated to cause elimination of cannabinoid 1 receptor (CB1) mediated long term depression (LTD) of GABA neurons in the ventral tegmental area (VTA) of the brain. Through electrophysiology and quantitative PCR experiments, this study reveals that LTD elimination is more pronounced in adolescents than adults, giving an explanation for the increased risk of THC dependency in adolescence. However, after a seven day withdrawal period, these effects were reversed. The data also supports the hypothesis that removal or desensitization of CB1 receptors from the synapse is an important mechanism of THC-induced neural and cognitive changes. ; https://scholarsarchive.byu.edu/library_studentposters_2023/1057/thumbnail.jpg |
| Document Type: | text |
| File Description: | application/pdf |
| Language: | English |
| Relation: | https://scholarsarchive.byu.edu/library_studentposters_2023/10; https://scholarsarchive.byu.edu/context/library_studentposters_2023/article/1057/viewcontent/THC_on_the_brain_poster.pdf |
| Availability: | https://scholarsarchive.byu.edu/library_studentposters_2023/10; https://scholarsarchive.byu.edu/context/library_studentposters_2023/article/1057/viewcontent/THC_on_the_brain_poster.pdf |
| Accession Number: | edsbas.FB917DE2 |
| Database: | BASE |
