| Title: |
Clinical standards for antimicrobial stewardship in TB care |
| Authors: |
Brehm, T T; Akkerman, O W; Sotgiu, G; Tiberi, S; Chang, K -C; Dheda, K; Duarte, R; Vambe, D; Udwadia, Z F; Chesov, D; Mendelson, M; Iswari Saktiawati, A M; van Ingen, J; Eyuboglu, F O; Tängdén, T; Quang Vo, L N; Riccardi, N; Moschos, C; Friedland, J S; Lillebaek, T; Chandy, S J; Caminero, J A; Thwaites, G; Gandra, S; Thursky, K; George, I A; Konstantynovska, O; Fatima, R; Yim, J-J; Kwak, N; Olaru, I D; Gillespie, S H; Kherabi, Y; Perl, S H; Grønningen, E; Rodrigues, C; Bjerrum, S; Bange, F; Cox, V; Cirillo, D M; Saluzzo, F; Hara, G L; Wagner, D; Ismail, N; Sloan, D J; Eshun-Wilsonova, I; Zeng, M; Cantero, C; Vasankari, T; Mandalakas, A; Kay, A; Ness, T; Torrico, M M; Günther, G; Kuksa, L; Guglielmetti, L; García-Basteiro, A L; Marks, G B; Pulcini, C; Lange, C |
| Contributors: |
European and Developing Countries; University of St Andrews.School of Medicine; University of St Andrews.Centre for Biophotonics; University of St Andrews.Biomedical Sciences Research Complex; University of St Andrews.Sir James Mackenzie Institute for Early Diagnosis; University of St Andrews.Infection and Global Health Division; University of St Andrews.Global Health Implementation Group |
| Publication Year: |
2026 |
| Collection: |
University of St Andrews: Digital Research Repository |
| Subject Terms: |
RA0421 Public health. Hygiene. Preventive Medicine; T-NDAS; SDG 3 - Good Health and Well-being; MCC; RA0421 |
| Description: |
Funding: SHG reports support from the European and Developing Countries Clinical Trials Partnership (EDCTP) for the SimpliciTB clinical trial. ; BACKGROUND: While antimicrobial stewardship (AMS) is essential for combating antimicrobial resistance (AMR), TB-specific AMS strategies remain poorly defined. METHODS: An international panel of 62 experts participated in a Delphi process. Using a 5-point Likert scale (5 = strong agreement; 1 = strong disagreement), participants evaluated 10 draft clinical standards developed by a core coordination team. A standard was adopted if ≥90% of respondents rated it three or higher, according to a predefined consensus threshold. RESULTS: All 10 standards reached the consensus threshold and were adopted: Standard 1, integration of TB into national AMR action plans; Standard 2, implementation of TB surveillance systems; Standard 3, education of health care providers, individuals affected by TB, and the public; Standard 4, integration of TB into AMS activities; Standard 5, establishment of expert consultation services; Standard 6, targeted testing and preventive treatment for individuals at risk for TB; Standard 7, access to timely and comprehensive drug susceptibility testing; Standard 8, prioritisation of efficacy, safety, and resistance prevention in TB treatment regimens; Standard 9, clinical and microbiological monitoring of treatment response; and Standard 10, assessment of adherence, drug exposure, and resistance in treatment failure. CONCLUSION: These clinical standards aim to support clinicians, programme managers, and public health authorities in implementing effective, TB-specific AMS strategies. ; Peer reviewed |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
IJTLD open; 331400398; 105026604748; PubMedCentral: PMC12699960; https://hdl.handle.net/10023/33432 |
| DOI: |
10.5588/ijtldopen.25.0522 |
| Availability: |
https://hdl.handle.net/10023/33432; https://doi.org/10.5588/ijtldopen.25.0522 |
| Rights: |
Copyright © 2025 The Authors. This is an open access article published by The Union under the terms of the Creative Commons Attribution License CC-BY. |
| Accession Number: |
edsbas.FBDEA9CC |
| Database: |
BASE |