| Title: |
Outcomes of CMML patients undergoing allo‐HCT are significantly worse compared to MDS—a study of the CMWP of the EBMT |
| Authors: |
Rovó, Alicia; Gras, Luuk; Piepenbroek, Brian; Kröger, Nicolaus; Reinhardt, H. Christian; Radujkovic, Aleksandar; Blaise, Didier; Kobbe, Guido; Niityvuopio, Riitta; Platzbecker, Uwe; Sockel, Katja; Hunault‐Berger, Mathilde; Cornelissen, J. J.; Forcade, Edouard; Bourhis, Jean Henri; Chalandon, Yves; Kinsella, Francesca; Nguyen‐Quoc, Stéphanie; Maertens, Johan; Elmaagacli, Ahmet; Mordini, Nicola; Hayden, Patrick; Raj, Kavita; Drozd‐Sokolowska, Joanna; de Wreede, Liesbeth C.; McLornan, Donal P.; Robin, Marie; Yakoub‐Agha, Ibrahim; Onida, Francesco |
| Contributors: |
A. Rovó; L. Gra; B. Piepenbroek; N. Kröger; H.C. Reinhardt; A. Radujkovic; D. Blaise; G. Kobbe; R. Niityvuopio; U. Platzbecker; K. Sockel; M. Hunault‐berger; J.J. Cornelissen; E. Forcade; J.H. Bourhi; Y. Chalandon; F. Kinsella; S. Nguyen‐quoc; J. Maerten; A. Elmaagacli; N. Mordini; P. Hayden; K. Raj; J. Drozd‐sokolowska; L.C. de Wreede; D.P. Mclornan; M. Robin; I. Yakoub‐agha; F. Onida |
| Publisher Information: |
WILEY |
| Publication Year: |
2024 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
CMML; MDS; Allo-SCT; Settore MED/15 - Malattie del Sangue; Settore MED/06 - Oncologia Medica |
| Description: |
Although CMML since long has been separated from MDS, many studies continue to evaluate the outcomes of both diseases after hematopoietic cell transplantation (allo-HCT) together. Data evaluating outcomes of a large CMML cohort after allo-HCT compared to MDS are limited. We aim to compare outcomes of CMML to MDS patients who underwent allo-HCT between 2010 and 2018. Patients >= 18 years with CMML and MDS undergoing allo-HCT reported to the EBMT registry were analyzed. Progression to AML before allo-HCT was an exclusion criterion. Overall survival (OS), progression/relapse-free survival (PFS), relapse incidence (including progression) (REL), and non-relapse mortality (NRM) were evaluated in univariable and multivariable (MVA) Cox proportional hazard models including interaction terms between disease and confounders. In total, 10832 patients who underwent allo-HCT were included in the study, there were a total of 1466 CMML, and 9366 MDS. The median age at time of allo-HCT in CMML (median 60.5, IQR 54.3-65.2 years) was significantly higher than in the MDS cohort (median 58.8, IQR 50.2-64.5 years; p < .001). A significantly higher percentage of CMML patients were male (69.4%) compared to MDS (61.2%; p < .001). There were no clinically meaningful differences in the distribution of Karnofsky score, Sorror HCT-CI score at allo-HCT, and donor type, between the CMML and MDS patients. RIC platforms were utilized in 63.9% of CMML allo-HCT, and in 61.4% of MDS patients (p = .08). In univariable analyses, we found that OS, PFS, and REL were significantly worse in CMML when compared with MDS (all p < .0001), whereas no significant difference was observed in NRM (p = .77). In multivariable analyses, the HR comparing MDS versus CMML for OS was 0.81 (95% CI, 0.74-0.88, p < .001), PFS 0.76 (95% CI 0.70-0.82, p < .001), relapse 0.66 (95% CI 0.59-0.74, p < .001), and NRM 0.87 (95% CI 0.78-0.98, p = .02), respectively. The association between baseline variables and outcome was found to be similar in MDS and CMML ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38009469; info:eu-repo/semantics/altIdentifier/wos/WOS:001109826100001; volume:99; issue:2; firstpage:203; lastpage:215; numberofpages:13; journal:AMERICAN JOURNAL OF HEMATOLOGY; https://hdl.handle.net/2434/1042872 |
| DOI: |
10.1002/ajh.27150 |
| Availability: |
https://hdl.handle.net/2434/1042872; https://doi.org/10.1002/ajh.27150 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.FBDF933F |
| Database: |
BASE |