| Title: |
The Adenovirus Dodecahedron: Beyond the Platonic Story |
| Authors: |
Besson, Solène; Vragniau, Charles; Vassal-Stermann, Emilie; Dagher, Marie Claire; Fender, Pascal |
| Contributors: |
Institut de biologie structurale (IBS - UMR 5075); Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG); Direction de Recherche Fondamentale (CEA) (DRF (CEA)); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA); Génomique et Évolution des Microorganismes (TIMC-IMAG-GEM); Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications Grenoble - UMR 5525 (TIMC-IMAG); VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP); Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP); Université Grenoble Alpes (UGA); ANR-18-CE11-0001,Ad-Cadh,Mécanisme d'interaction des adenovirus du sous-groupe B2 à la cadhérine desmosomale DSG2 et ses applications(2018) |
| Source: |
ISSN: 1999-4915 ; Viruses ; https://hal.science/hal-02993412 ; Viruses, 2020, 12 (7), pp.718. ⟨10.3390/v12070718⟩. |
| Publisher Information: |
CCSD; MDPI |
| Publication Year: |
2020 |
| Collection: |
Université Grenoble Alpes: HAL |
| Subject Terms: |
Viral spreading; Structure; Vaccines; Receptors; Virus Like Particles; Platonic solids; Dodecahedron; Adenovirus; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Many geometric forms are found in nature, some of them adhering to mathematical laws or amazing aesthetic rules. One of the best-known examples in microbiology is the icosahedral shape of certain viruses with 20 triangular facets and 12 edges. What is less known, however, is that a complementary object displaying 12 faces and 20 edges called a 'dodecahedron' can be produced in huge amounts during certain adenovirus replication cycles. The decahedron was first described more than 50 years ago in the human adenovirus (HAdV3) viral cycle. Later on, the expression of this recombinant scaffold, combined with improvements in cryo-electron microscopy, made it possible to decipher the structural determinants underlying their architecture. Recently, this particle, which mimics viral entry, was used to fish the long elusive adenovirus receptor, desmoglein-2, which serves as a cellular docking for some adenovirus serotypes. This breakthrough enabled the understanding of the physiological role played by the dodecahedral particles, showing that icosahedral and dodecahedral particles live more than a simple platonic story. All these points are developed in this review, and the potential use of the dodecahedron in therapeutic development is discussed. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.3390/v12070718 |
| Availability: |
https://hal.science/hal-02993412; https://hal.science/hal-02993412v1/document; https://hal.science/hal-02993412v1/file/Besson%20et%20al.%20-%202020%20-%20The%20Adenovirus%20Dodecahedron%20Beyond%20the%20Platonic%20S.pdf; https://doi.org/10.3390/v12070718 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.FBF60581 |
| Database: |
BASE |