| Title: |
Polygenic hazard score is associated with prostate cancer in multi-ethnic populations. |
| Authors: |
Huynh-Le, M-P; Fan, CC; Karunamuni, R; Thompson, WK; Martinez, ME; Eeles, RA; Kote-Jarai, Z; Muir, K; Schleutker, J; Pashayan, N; Batra, J; Grönberg, H; Neal, DE; Donovan, JL; Hamdy, FC; Martin, RM; Nielsen, SF; Nordestgaard, BG; Wiklund, F; Tangen, CM; Giles, GG; Wolk, A; Albanes, D; Travis, RC; Blot, WJ; Zheng, W; Sanderson, M; Stanford, JL; Mucci, LA; West, CML; Kibel, AS; Cussenot, O; Berndt, SI; Koutros, S; Sørensen, KD; Cybulski, C; Grindedal, EM; Menegaux, F; Khaw, K-T; Park, JY; Ingles, SA; Maier, C; Hamilton, RJ; Thibodeau, SN; Rosenstein, BS; Lu, Y-J; Watya, S; Vega, A; Kogevinas, M; Penney, KL; Huff, C; Teixeira, MR; Multigner, L; Leach, RJ; Cannon-Albright, L; Brenner, H; John, EM; Kaneva, R; Logothetis, CJ; Neuhausen, SL; De Ruyck, K; Pandha, H; Razack, A; Newcomb, LF; Fowke, JH; Gamulin, M; Usmani, N; Claessens, F; Gago-Dominguez, M; Townsend, PA; Bush, WS; Roobol, MJ; Parent, M-É; Hu, JJ; Mills, IG; Andreassen, OA; Dale, AM; Seibert, TM; UKGPCS collaborators; APCB (Australian Prostate Cancer BioResource); NC-LA PCaP Investigators; IMPACT Study Steering Committee and Collaborators; Canary PASS Investigators; Profile Study Steering Committee; PRACTICAL Consortium |
| Contributors: |
Eeles, Rosalind; Kote-Jarai, Zsofia |
| Publisher Information: |
NATURE PORTFOLIO |
| Publication Year: |
2021 |
| Collection: |
The Institute of Cancer Research (ICR): Publications Repository |
| Subject Terms: |
UKGPCS collaborators; APCB (Australian Prostate Cancer BioResource); NC-LA PCaP Investigators; IMPACT Study Steering Committee and Collaborators; Canary PASS Investigators; Profile Study Steering Committee; PRACTICAL Consortium; Humans; Prostatic Neoplasms; Neoplasm Invasiveness; Multivariate Analysis; Multifactorial Inheritance; Aged; Middle Aged; Ethnic Groups; Male; Self Report |
| Description: |
Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p < 10-180). Comparing the 80th/20th PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset. |
| Document Type: |
article in journal/newspaper |
| File Description: |
Electronic; ?; application/pdf |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
Nature communications, 2021, 12 (1), pp. 1236 - ?; https://repository.icr.ac.uk/handle/internal/4484 |
| Availability: |
https://repository.icr.ac.uk/handle/internal/4484 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 |
| Accession Number: |
edsbas.FC75618 |
| Database: |
BASE |