| Title: |
Peptides derived from the heptad repeat region near the C‐terminal of Sendai virus F protein bind the hemagglutinin‐neuraminidase ectodomain |
| Authors: |
Tomasi, Maurizio; Pasti, Claudia; Manfrinato, Cristina; Dallocchio, Franco; Bellini, Tiziana |
| Source: |
FEBS Letters ; volume 536, issue 1-3, page 56-60 ; ISSN 0014-5793 1873-3468 |
| Publisher Information: |
Wiley |
| Publication Year: |
2003 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Previously, we showed that Sendai virus fusion protein (F) acts as an inhibitor of neuraminidase activity of hemagglutinin‐neuraminidase (HN) protein. Here we report that synthetic peptides derived from the heptad repeat region proximal to the transmembrane domain (HR2) of Sendai virus F inhibit fusion and enhance the enzymatic activity of the HN. This occurs on the virus‐bound HN and on its soluble globular head. The enhancing effect on virus‐bound HN is reversible and depends on the presence of F. The data indicate that, by binding to the HN ectodomain, the HR2 peptides abolish the F inhibition of HN and disrupt the communication between the F and HN essential to promote virus–cell fusion. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1016/s0014-5793(03)00010-3 |
| DOI: |
10.1016/S0014-5793%2803%2900010-3 |
| Availability: |
https://doi.org/10.1016/s0014-5793(03)00010-3; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2FS0014-5793%2803%2900010-3; https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/S0014-5793%2803%2900010-3 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.FCC92566 |
| Database: |
BASE |