| Title: |
Validity of the Chronic Airways Assessment Test (CAAT) in asthma, asthma+COPD and COPD in NOVELTY |
| Authors: |
Jones, PW; Tomaszewski, EL; Belton, L; Burgel, P-R; Hughes, R; Keen, C; Make, BJ; Papi, A; Müllerová, H; Reddel, HK |
| Publisher Information: |
European Respiratory Society (ERS) |
| Publication Year: |
2025 |
| Collection: |
St George's University of London: Repository |
| Description: |
Background To assess health status in respiratory diseases, the Chronic Airways Assessment Test (CAAT) was adapted from the COPD Assessment Test (CAT) by replacing COPD-specific wording. It has demonstrated good psychometric properties in asthma and/or COPD. This cross-sectional analysis evaluated how CAAT scores are associated with clinical characteristics in patients with asthma and/or COPD. Methods Using baseline NOVELTY data (NCT02760329) for patients with physician-assigned asthma and/or COPD, linear regression models were implemented to assess the association between CAAT score (range 0–40; higher scores indicating worse health status) and physician-assessed severity, lung function, modified Medical Research Council dyspnoea grade, Respiratory Symptoms Questionnaire score and, for asthma and asthma+COPD, symptom control assessed by Asthma Control Test score. Results Among 7828 patients (asthma: 4138; asthma+COPD: 991; COPD: 2699), CAAT score was lower in patients with asthma (mean±sd 14.0±8.5) versus patients with asthma+COPD (17.2±8.6) or COPD (17.0±8.3), indicating better health status in asthma. Associations between CAAT score and clinical characteristics were similar across diagnostic groups (interaction p-values >0.01), with higher CAAT scores associated with more respiratory symptoms, greater exercise limitation due to breathlessness, lower lung function, worse physician-assessed severity and (in asthma+COPD) with worse asthma symptom control. CAAT scores among those with asthma were lower versus other diagnostic groups by physician-assessed severities. Findings were similar when adjusting for age and for age, sex and smoking status. Conclusion The CAAT demonstrated consistent cross-sectional validity across asthma and/or COPD, making it applicable for assessing health status in these conditions in clinical practice and research. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
2312-0541 |
| Relation: |
https://openaccess.sgul.ac.uk/id/eprint/117785/1/ERJ%20Open%20Res-2025-Jones-01359-2024.pdf; https://openaccess.sgul.ac.uk/id/eprint/117785/2/inline-supplementary-material-1.pdf; Jones, PW; Tomaszewski, EL; Belton, L; Burgel, P-R; Hughes, R; Keen, C; Make, BJ; Papi, A; Müllerová, H; Reddel, HK (2025) Validity of the Chronic Airways Assessment Test (CAAT) in asthma, asthma+COPD and COPD in NOVELTY. ERJ Open Research, 11 (4). 01359-2024. ISSN 2312-0541 https://doi.org/10.1183/23120541.01359-2024 SGUL Authors: Jones, Paul Wyatt |
| DOI: |
10.1183/23120541.01359-2024 |
| Availability: |
https://openaccess.sgul.ac.uk/id/eprint/117785/; https://doi.org/10.1183/23120541.01359-2024 |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.FD0F79D8 |
| Database: |
BASE |