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A highly virulent variant of HIV-1 circulating in the Netherlands

Title: A highly virulent variant of HIV-1 circulating in the Netherlands
Authors: Wymant, Chris; Bezemer, Daniela; Blanquart, François; Ferretti, Luca; Gall, Astrid; Hall, Matthew; Golubchik, Tanya; Bakker, Margreet; Ong, Swee Hoe; Zhao, Lele; Bonsall, David; de Cesare, Mariateresa; MacIntyre-Cockett, George; Abeler-Dörner, Lucie; Albert, Jan; Bannert, Norbert; Fellay, Jacques; Grabowski, M Kate; Gunsenheimer-Bartmeyer, Barbara; Günthard, Huldrych F; Kivelä, Pia; Kouyos, Roger D; Laeyendecker, Oliver; Meyer, Laurence; Porter, Kholoud; Ristola, Matti; van Sighem, Ard; Berkhout, Ben; Kellam, Paul; Cornelissen, Marion; Reiss, Peter; Fraser, Christophe; Aubert, V; Battegay, M; Bernasconi, E; Böni, J; Braun, D L; Bucher, H C; Burton-Jeangros, C; Calmy, A; Cavassini, M; Dollenmaier, G; Egger, M; Elzi, L; Fehr, J; Fellay, J; Furrer, H; Fux, C A; Gorgievski, M; Günthard, H; Haerry, D; Hasse, B; Hirsch, H H; Hoffmann, M; Hösli, I; Kahlert, C; Kaiser, L; Keiser, O; Klimkait, T; Kouyos, R; Kovari, H; Ledergerber, B; Martinetti, G; de Tejada, B Martinez; Marzolini, C; Metzner, K; Müller, N; Nadal, D; Nicca, D; Pantaleo, G; Rauch, A; Regenass, S; Rudin, C; Schöni-Affolter, F; Schmid, P; Speck, R; Stöckle, M; Tarr, P; Trkola, A; Vernazza, P; Weber, R; Yerly, S; van der Valk, M; Geerlings, S E; Goorhuis, A; Hovius, J W; Lempkes, B; Nellen, F J B; van der Poll, T; Prins, J M; Reiss, P; van Vugt, M; Wiersinga, W J; Wit, F W M N; van Duinen, M; van Eden, J; Hazenberg, A; van Hes, A M H; Pijnappel, F J J; Smalhout, S Y; Weijsenfeld, A M; Jurriaans, S; Back, N K T; Zaaijer, H L; Berkhout, B; Cornelissen, M T E; Schinkel, C J; Wolthers, K C; Peters, E J G; van Agtmael, M A; Autar, R S; Bomers, M; Sigaloff, K C E; Heitmuller, M; Laan, L M; Ang, C W; van Houdt, R; Jonges, M; Kuijpers, T W; Pajkrt, D; Scherpbier, H J; de Boer, C; van der Plas, A; van den Berge, M; Stegeman, A; Baas, S; Hage de Looff, L; Buiting, A; Reuwer, A; Veenemans, J; Wintermans, B; Pronk, M J H; Ammerlaan, H S M; van den Bersselaar, D N J; de Munnik, E S; Deiman, B; Jansz, A R; Scharnhorst, V; Tjhie, J; Wegdam, M C A; van Eeden, A; Nellen, J; Brokking, W; Elsenburg, L J M; Nobel, H; van Kasteren, M E E; Berrevoets, M A H; Brouwer, A E; Adams, A; van Erve, R; de Kruijf-van de Wiel, B A F M; Keelan-Phaf, S; van der Ven, B; Buiting, A G M; Murck, J L; de Vries-Sluijs, T E M S; Bax, H I; van Gorp, E C M; de Jong-Peltenburg, N C; de Mendonç A Melo, M; van Nood, E; Nouwen, J L; Rijnders, B J A; Rokx, C; Schurink, C A M; Slobbe, L; Verbon, A; Bassant, N; van Beek, J E A; Vriesde, M; van Zonneveld, L M; de Groot, J; Boucher, C A B; Koopmans, M P G; van Kampen, J J A; Fraaij, P L A; van Rossum, A M C; Vermont, C L; van der Knaap, L C; Visser, E; Branger, J; Douma, R A; Cents-Bosma, A S; Duijf-van de Ven, C J H M; Schippers, E F; van Nieuwkoop, C; van Ijperen, J M; Geilings, J; van der Hut, G; van Burgel, N D; Leyten, E M S; Gelinck, L B S; Mollema, F; Davids-Veldhuis, S; Tearno, C; Wildenbeest, G S; Heikens, E; Groeneveld, P H P; Bouwhuis, J W; Lammers, A J J; Kraan, S; van Hulzen, A G W; Kruiper, M S M; van der Bliek, G L; Bor, P C J; Debast, S B; Wagenvoort, G H J; Kroon, F P; de Boer, M G J; Jolink, H; Lambregts, M M C; Roukens, A H E; Scheper, H; Dorama, W; van Holten, N; Claas, E C J; Wessels, E; den Hollander, J G; El Moussaoui, R; Pogany, K; Smit, J V; Struik-Kalkman, D; van Niekerk, T; Pontesilli, O; Lowe, S H; Oude Lashof, A M L; Posthouwer, D; van Wolfswinkel, M E; Ackens, R P; Burgers, K; Schippers, J; Weijenberg-Maes, B; van Loo, I H M; Havenith, T R A; van Vonderen, M G A; Kampschreur, L M; Faber, S; Steeman-Bouma, R; Al Moujahid, A; Kootstra, G J; Delsing, C E; van der Burg-van de Plas, M; Scheiberlich, L; Kortmann, W; van Twillert, G; Renckens, R; Ruiter-Pronk, D; van Truijen-Oud, F A; Cohen Stuart, J W T; Jansen, E R; Hoogewerf, M; Rozemeijer, W; van der Reijden, W A; Sinnige, J C; Brinkman, K; van den Berk, G E L; Blok, W L; Lettinga, K D; de Regt, M; Schouten, W E M; Stalenhoef, J E; Veenstra, J; Vrouenraets, S M E; Blaauw, H; Geerders, G F; Kleene, M J; Kok, M; Knapen, M; van der Meché, I B; Mulder-Seeleman, E; Toonen, A J M; Wijnands, S; Wttewaal, E; Kwa, D; van Crevel, R; van Aerde, K; Dofferhoff, A S M; Henriet, S S V; Ter Hofstede, H J M; Hoogerwerf, J; Keuter, M; Richel, O; Albers, M; Grintjes-Huisman, K J T; de Haan, M; Marneef, M; Strik-Albers, R; Rahamat-Langendoen, J; Stelma, F F; Burger, D; Gisolf, E H; Hassing, R J; Claassen, M; Ter Beest, G; van Bentum, P H M; Langebeek, N; Tiemessen, R; Swanink, C M A; van Lelyveld, S F L; Soetekouw, R; van der Prijt, L M M; van der Swaluw, J; Bermon, N; Jansen, R; Herpers, B L; Veenendaal, D; Verhagen, D W M; Lauw, F N; van Broekhuizen, M C; van Wijk, M; Bierman, W F W; Bakker, M; Kleinnijenhuis, J; Kloeze, E; Middel, A; Postma, D F; Schölvinck, E H; Stienstra, Y; Verhage, A R; Wouthuyzen-Bakker, M; Boonstra, A; de Groot-de Jonge, H; van der Meulen, P A; de Weerd, D A; Niesters, H G M; van Leer-Buter, C C; Knoester, M; Hoepelman, A I M; Arends, J E; Barth, R E; Bruns, A H W; Ellerbroek, P M; Mudrikova, T; Oosterheert, J J; Schadd, E M; van Welzen, B J; Aarsman, K; Griffioen-van Santen, B M G; de Kroon, I; van Berkel, M; van Rooijen, C S A M; Schuurman, R; Verduyn-Lunel, F; Wensing, A M J; Bont, L J; Geelen, S P M; Loeffen, Y G T; Wolfs, T F W; Nauta, N; Rooijakkers, E O W; Holtsema, H; Voigt, R; van de Wetering, D; Alberto, A; van der Meer, I; Rosingh, A; Halaby, T; Zaheri, S; Boyd, A C; Bezemer, D O; van Sighem, A I; Smit, C; Hillebregt, M; de Jong, A; Woudstra, T; Bergsma, D; Meijering, R; van de Sande, L; Rutkens, T; van der Vliet, S; de Groot, L; van den Akker, M; Bakker, Y; El Berkaoui, A; Bezemer, M; Brétin, N; Djoechro, E; Groters, M; Kruijne, E; Lelivelt, K J; Lodewijk, C; Lucas, E; Munjishvili, L; Paling, F; Peeck, B; Ree, C; Regtop, R; Ruijs, Y; Schoorl, M; Schnörr, P; Scheigrond, A; Tuijn, E; Veenenberg, L; Visser, K M; Witte, E C; Van Frankenhuijsen, Maartje; Allegre, Thierry; Makhloufi, Djamila; Livrozet, Jean-Michel; Chiarello, Pierre; Godinot, Mathieu; Brunel-Dalmas, Florence; Gibert, Sylvie; Trepo, Christian; Peyramond, Dominique; Miailhes, Patrick; Koffi, Joseph; Thoirain, Valérie; Brochier, Corinne; Baudry, Thomas; Pailhes, Sylvie; Lafeuillade, Alain; Philip, Gisèle; Hittinger, Gilles; Assi, Assi; Lambry, Véronique; Rosenthal, Eric; Naqvi, Alissa; Dunais, Brigitte; Cua, Eric; Pradier, Christian; Durant, Jacques; Joulie, Aline; Quinsat, Denis; Tempesta, Serge; Ravaux, Isabelle; Martin, Isabelle Poizot; Faucher, Olivia; Cloarec, Nicolas; Champagne, Hélène; Pichancourt, Gilles; Morlat, Philippe; Pistone, Thierry; Bonnet, Fabrice; Mercie, Patrick; Faure, Isabelle; Hessamfar, Mojgan; Malvy, Denis; Lacoste, Denis; Pertusa, Marie-Carmen; Vandenhende, Marie-Anne; Bernard, Noëlle; Paccalin, François; Martell, Cédric; Roger-Schmelz, Julien; Receveur, Marie-Catherine; Duffau, Pierre; Dondia, Denis; Ribeiro, Emmanuel; Caltado, Sabrina; Neau, Didier; Dupont, Michel; Dutronc, Hervé; Dauchy, Frédéric; Cazanave, Charles; Vareil, Marc-Olivier; Wirth, Gaétane; Le Puil, Séverine; Pellegrin, Jean-Luc; Raymond, Isabelle; Viallard, Jean-François; Chaigne de Lalande, Severin; Garipuy, Daniel; Delobel, Pierre; Obadia, Martine; Cuzin, Lise; Alvarez, Muriel; Biezunski, Noemie; Porte, Lydie; Massip, Patrice; Debard, Alexa; Balsarin, Florence; Lagarrigue, Myriam; Prevoteau du Clary, François; Aquilina, Christian; Reynes, Jacques; Baillat, Vincent; Merle, Corinne; Lemoing, Vincent; Atoui, Nadine; Makinson, Alain; Jacquet, Jean Marc; Psomas, Christina; Tramoni, Christine; Aumaitre, Hugues; Saada, Mathieu; Medus, Marie; Malet, Martine; Eden, Aurélia; Neuville, Ségolène; Ferreyra, Milagros; Sotto, Albert; Barbuat, Claudine; Rouanet, Isabelle; Leureillard, Didier; Mauboussin, Jean-Marc; Lechiche, Catherine; Donsesco, Régine; Cabie, André; Abel, Sylvie; Pierre-Francois, Sandrine; Batala, Anne-Sophie; Cerland, Christophe; Rangom, Camille; Theresine, Nadine; Hoen, Bruno; Lamaury, Isabelle; Fabre, Isabelle; Schepers, Kinda; Curlier, Elodie; Ouissa, Rachida; Gaud, Catherine; Ricaud, Carole; Rodet, Roland; Wartel, Guillaume; Sautron, Carmele; Beck-Wirth, Geneviève; Michel, Catherine; Beck, Charles; Halna, Jean-Michel; Kowalczyk, Jakub; Benomar, Meryem; Drobacheff-Thiebaut, Christine; Chirouze, Catherine; Faucher, Jean-François; Parcelier, François; Foltzer, Adeline; Haffner-Mauvais, Cécile; Hustache Mathieu, Mathieu; Proust, Aurélie; Piroth, Lionel; Chavanet, Pascal; Duong, Michel; Buisson, Marielle; Waldner, Anne; Mahy, Sophie; Gohier, Sandrine; Croisier, Delphine; May, Thierry; Delestan, Mikael; Andre, Marie; Zadeh, Mahsa Mohseni; Martinot, Martin; Rosolen, Béatrice; Pachart, Anne; Martha, Benoît; Jeunet, Noëlle; Rey, David; Cheneau, Christine; Partisani, Maria; Priester, Michèle; Bernard-Henry, Claudine; Batard, Marie-Laure; Fischer, Patricia; Berger, Jean-Luc; Kmiec, Isabelle; Robineau, Olivier; Huleux, Thomas; Ajana, Faïza; Alcaraz, Isabelle; Allienne, Christophe; Baclet, Véronique; Meybeck, Agnès; Valette, Michel; Viget, Nathalie; Aissi, Emmanuelle; Biekre, Raphael; Cornavin, Pauline; Merrien, Dominique; Seghezzi, Jean-Christophe; Machado, Moise; Diab, Georges; Raffi, François; Bonnet, Bénédicte; Allavena, Clotilde; Grossi, Olivier; Reliquet, Véronique; Billaud, Eric; Brunet, Cecile; Bouchez, Sabelline; Morineau-Le Houssine, Pascale; Sauser, Fabienne; Boutoille, David; Besnier, Michel; Hue, Hervé; Hall, Nolwenn; Brosseau, Delphine; Souala, Faouzi; Michelet, Christian; Tattevin, Pierre; Arvieux, Cédric; Revest, Matthieu; Leroy, Helene; Chapplain, Jean-Marc; Dupont, Matthieu; Fily, Fabien; Patra-Delo, Solène; Lefeuvre, Céline; Bernard, Louis; Bastides, Frédéric; Nau, Pascale; Verdon, Renaud; de la Blanchardiere, Arnaud; Martin, Anne; Feret, Philippe; Geffray, Loïk; Daniel, Corinne; Rohan, Jennifer; Fialaire, Pascale; Chennebault, Jean Marie; Rabier, Valérie; Abgueguen, Pierre; Rehaiem, Sami; Luycx, Odile; Niault, Mathilde; Moreau, Philippe; Poinsignon, Yves; Goussef, Marie; Mouton-Rioux, Virginie; Houlbert, Dominique; Alvarez-Huve, Sandrine; Barbe, Frédérique; Haret, Sophie; Perre, Philippe; Leantez-Nainville, Sophie; Esnault, Jean-Luc; Guimard, Thomas; Suaud, Isabelle; Girard, Jean-Jacques; Simonet, Véronique; Debab, Yasmine; Schmit, Jean-Luc; Jacomet, Christine; Weinberck, Pierre; Genet, Claire; Pinet, Pauline; Ducroix, Sophie; Durox, Hélène; Denes, Éric; Abraham, Bruno; Gourdon, Florence; Antoniotti, Odile; Molina, Jean-Michel; Ferret, Samuel; Lascoux-Combe, Caroline; Lafaurie, Matthieu; Colin de Verdiere, Nathalie; Ponscarme, Diane; De Castro, Nathalie; Aslan, Alexandre; Rozenbaum, Willy; Pintado, Claire; Clavel, François; Taulera, Olivier; Gatey, Caroline; Munier, Anne-Lise; Gazaigne, Sandrine; Penot, Pauline; Conort, Guillaume; Lerolle, Nathalie; Leplatois, Anne; Balausine, Stéphanie; Delgado, Jeannine; Timsit, Julie; Tabet, Magda; Gerard, Laurence; Girard, Pierre-Marie; Picard, Odile; Tredup, Jürgen; Bollens, Diane; Valin, Nadia; Campa, Pauline; Bottero, Julie; Lefebvre, Benedicte; Tourneur, Muriel; Fonquernie, Laurent; Wemmert, Charlotte; Lagneau, Jean-Luc; Yazdanpanah, Yazdan; Phung, Bao; Pinto, Adriana; Vallois, Dorothée; Cabras, Ornella; Louni, Françoise; Pialoux, Gilles; Lyavanc, Thomas; Berrebi, Valérie; Chas, Julie; Lenagat, Sophie; Rami, Agathe; Diemer, Myriam; Parrinello, Maguy; Depond, Audrey; Salmon, Dominique; Guillevin, Loïc; Tahi, Tassadit; Belarbi, Linda; Loulergue, Pierre; Zak Dit Zbar, Olivier; Launay, Odile; Silbermann, Benjamin; Leport, Catherine; Alagna, Laura; Pietri, Marie-Pierre; Simon, Anne; Bonmarchand, Manuela; Amirat, Naouel; Pichon, François; Kirstetter, Myriam; Katlama, Christine; Valantin, Marc Antoine; Tubiana, Roland; Caby, Fabienne; Schneider, Luminita; Ktorza, Nadine; Calin, Ruxandra; Merlet, Audrey; Ben Abdallah, Saadia; Weiss, Laurence; Buisson, Martin; Batisse, Dominique; Karmochine, Marina; Pavie, Juliette; Minozzi, Catherine; Jayle, Didier; Castel, Philippe; Derouineau, Jean; Kousignan, Pascale; Eliazevitch, Murielle; Pierre, Isabelle; Collias, Lio; Viard, Jean-Paul; Gilquin, Jacques; Sobel, Alain; Slama, Laurence; Ghosn, Jade; Hadacek, Blanka; Thu-Huyn, Nugyen; Nait-Ighil, Lella; Cros, Agnes; Maignan, Aline; Duvivier, Claudine; Consigny, Paul Henri; Lanternier, Fanny; Shoai-Tehrani, Michka; Touam, Fatima; Jerbi, Saadia; Bodard, Loïc; Jung, Corinne; Goujard, Cécile; Quertainmont, Yann; Duracinsky, Martin; Segeral, Olivier; Blanc, Arnaud; Peretti, Delphine; Cheret, Antoine; Chantalat, Christelle; Dulucq, Marie Josée; Levy, Yves; Lelievre, Jean Daniel; Lascaux, Anne Sophie; Dumont, Cécile; Boue, François; Chambrin, Véronique; Abgrall, Sophie; Kansau, Imad; Raho-Moussa, Mariem; De Truchis, Pierre; Dinh, Aurélien; Davido, Benjamin; Marigot, Dhiba; Berthe, Huguette; Devidas, Alain; Chevojon, Pierre; Chabrol, Amélie; Agher, Nouara; Lemercier, Yvon; Chaix, Fabrice; Turpault, Isabelle; Bouchaud, Olivier; Honore, Patricia; Rouveix, Elisabeth; Reimann, Evelyne; Belan, Alix Greder; Godin Collet, Claire; Souak, Safia; Mortier, Emmanuel; Bloch, Martine; Simonpoli, Anne-Marie; Manceron, Véronique; Cahitte, Isabelle; Hiraux, Emmanuel; Lafon, Erik; Cordonnier, François; Zeng, Ai-Feng; Zucman, David; Majerholc, Catherine; Bornarel, Dominique; Uludag, Agnès; Gellen-Dautremer, Justine; Lefort, Agnès; Bazin, Christine; Daneluzzi, Vincent; Gerbe, Juliette; Jeantils, Vincent; Coupard, Mélissa; Patey, Olivier; Bantsimba, Jonas; Delllion, Sophie; Paz, Pauline Caraux; Cazenave, Benoit; Richier, Laurent; Garrait, Valérie; Delacroix, Isabelle; Elharrar, Brigitte; Vittecoq, Daniel; Bolliot, Claudine; Lepretre, Annie; Genet, Philippe; Masse, Virginie; Perrone, Véronique; Boussard, Jean-Luc; Chardon, Patricia; Froguel, Eric; Simon, Philippe; Tassi, Sylvie; Avettand Fenoel, Véronique; Barin, Francis; Bourgeois, Christine; Cardon, Fanny; Chaix, Marie-Laure; Delfraissy, Jean François; Essat, Asma; Fischer, Hugues; Lecuroux, Camille; Petrov-Sanchez, Ventzislava; Rouzioux, Christine; Saez-Cirion, Asier; Seng, Rémonie; Kuldanek, Kristin; Mullaney, Scott; Young, Carmel; Zucchetti, Antonella; Bevan, Margaret-Ann; McKernan, Sinead; Wandolo, Emily; Richardson, Celia; Youssef, Elaney; Green, Pippa; Faulkner, Sue; Faville, Rebecca; Herman, Sandra; Care, Christine; Blackman, Helen; Bellenger, Katharine; Fairbrother, Keith; Phillips, Andrew; Babiker, Abdel; Delpech, Valerie; Fidler, S; Clarke, Mindy; Fox, Julie; Gilson, R; Goldberg, David; Hawkins, David; Johnson, Anne; Johnson, Margaret; McLean, Ken; Nastouli, Eleni; Post, Frank; Kennedy, N; Pritchard, J; Andrady, U; Rajda, N; Donnelly, C; McKernan, S; Drake, S; Gilleran, G; White, D; Ross, J; Harding, J; Faville, R; Sweeney, J; Flegg, P; Toomer, S; Wilding, H; Woodward, R; Dean, G; Richardson, C; Perry, N; Gompels, M; Jennings, L; Bansaal, D; Browing, M; Connolly, L; Stanley, B; Estreich, S; Magdy, A; O'Mahony, C; Fraser, P; Jebakumar, S P R; David, L; Mette, R; Summerfield, H; Evans, M; White, C; Robertson, R; Lean, C; Morris, S; Winter, A; Faulkner, S; Goorney, B; Howard, L; Fairley, I; Stemp, C; Short, L; Gomez, M; Young, F; Roberts, M; Green, S; Sivakumar, K; Minton, J; Siminoni, A; Calderwood, J; Greenhough, D; DeSouza, C; Muthern, Lisa; Orkin, C; Murphy, S; Truvedi, M; McLean, K; Hawkins, D; Higgs, C; Moyes, A; Antonucci, S; McCormack, S; Lynn, W; Bevan, M; Fox, J; Teague, A; Anderson, J; Mguni, S; Post, F; Campbell, L; Mazhude, C; Russell, H; Carrick, G; Ainsworth, J; Waters, A; Byrne, P; Johnson, M; Kuldanek, K; Mullaney, S; Lawlor, V; Melville, R; Sukthankar, A; Thorpe, S; Murphy, C; Wilkins, E; Ahmad, S; Green, P; Tayal, S; Ong, E; Meaden, J; Riddell, L; Loay, D; Peacock, K; Blackman, H; Harindra, V; Saeed, A M; Allen, S; Natarajan, U; Williams, O; Lacey, H; Care, C; Bowman, C; Herman, S; Devendra, S V; Wither, J; Bridgwood, A; Singh, G; Bushby, S; Kellock, D; Young, S; Rooney, G; Snart, B; Currie, J; Fitzgerald, M; Arumainayyagam, J; Chandramani, S; Rajamanoharan, S; Robinson, T; Taylor, B; Brewer, C; Mayr, Christoph; Schmidt, Wolfgang; Speidel, Andrea; Strohbach, Frank; Arastéh, Keikawus; Cordes, Christiane; Stündel, Manfred; Claus, Jörg; Baumgarten, Axel; Carganico, Andreas; Ingiliz, Patrick; Dupke, Stephan; Freiwald, Matthias; Rausch, Michael; Moll, Arend; Schleehauf, Dorothea; Hintsche, Bettina; Klausen, Gerd; Jessen, Heiko; Jessen, Arne; Köppe, Siegfried; Kreckel, Peter; Schranz, Dietmar; Fischer, Klaus; Schulbin, Hubert; Speer, Miriam; Glaunsinger, Tobias; Wicke, Thomas; Bieniek, Bernhard; Hillenbrand, Heribert; Schlote, Frank; Lauenroth-Mai, Elke; Schuler, Christoph; Schürmann, Dirk; Wesselmann, Hans; Brockmeyer, Norbert; Gehring, Peter; Schmalöer, Dirk; Hower, Martin; Spornraft-Ragaller, Petra; Häussinger, Dieter; Reuter, Stefan; Esser, Stefan; Markus, Rudolf; Kreft, Burkhard; Berzow, Dirk; Christl, Andreas; Meyer, Andreas; Plettenberg, Andreas; Stoehr, Albrecht; Graefe, Katrin; Lorenzen, Thore; Adam, Axel; Schewe, Knut; Weitner, Lutwin; Fenske, Stefan; Hansen, Stefan; Stellbrink, Hans-Jürgen; Wiemer, Dorothea; Hertling, Sandra; Schmidt, Reinhold; Arbter, Peter; Claus, Bernd; Galle, Peter; Jäger, Hans; Jä Gel-Guedes, Eva; Postel, Nils; Fröschl, Monika; Spinner, Christoph; Bogner, Johannes; Salzberger, Bernd; Schölmerich, Jürgen; Audebert, Franz; Marquardt, Ties; Schaffert, Andreas; Schnaitmann, Eiko; Trein, Andreas; Frietsch, Bernhard; Müller, Marcus; Ulmer, Albrecht; Detering-Hübner, Barbara; Kern, Peter; Schubert, Franz; Dehn, Günther; Schreiber, Maria; Güler, Cengiz; Schmidt, Daniel; Meixenberger, Karolin
Source: Wymant, C, Bezemer, D, Blanquart, F, Ferretti, L, Gall, A, Hall, M, Golubchik, T, Bakker, M, Ong, S H, Zhao, L, Bonsall, D, de Cesare, M, MacIntyre-Cockett, G, Abeler-Dörner, L, Albert, J, Bannert, N, Fellay, J, Grabowski, M K, Gunsenheimer-Bartmeyer, B, Günthard, H F, Kivelä, P, Kouyos, R D, Laeyendecker, O, Meyer, L, Porter, K, Ristola, M, van Sighem, A, Berkhout, B, Kellam, P, Cornelissen, M, Reiss, P, Fraser, C, Aubert, V, Battegay, M, Bernasconi, E, Böni, J, Braun, D L, Bucher, H C, Burton-Jeangros, C, Calmy, A, Cavassini, M, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, ....
Publication Year: 2022
Description: We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV-CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences-is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.
Document Type: article in journal/newspaper
Language: English
ISSN: 0036-8075; 1095-9203
Relation: info:eu-repo/semantics/altIdentifier/pmid/35113714; info:eu-repo/semantics/altIdentifier/pissn/0036-8075; info:eu-repo/semantics/altIdentifier/eissn/1095-9203
DOI: 10.1126/science.abk1688
Availability: https://research.vumc.nl/en/publications/b1227ff3-359f-455e-bf7b-ac8308fcf500; https://doi.org/10.1126/science.abk1688; https://www.scopus.com/pages/publications/85124019619
Rights: info:eu-repo/semantics/openAccess
Accession Number: edsbas.FD21B460
Database: BASE