Genome-wide analysis of constitutional DNA methylation in familial melanoma
| Title: | Genome-wide analysis of constitutional DNA methylation in familial melanoma |
|---|---|
| Authors: | Salgado, Catarina; Gruis, Nelleke; Bonder, Marc Jan; Luijk, René; Zhernakova, Dasha V.; Moed, Matthijs; Deelen, Patrick; Vermaat, Martijn; Van Iterson, Maarten; Van Dijk, Freerk; Van Galen, Michiel; Bot, Jan; Jhamai, P. Mila; Verbiest, Michael; Suchiman, H. Eka D.; Verkerk, Marijn; Van Der Breggen, Ruud; Van Rooij, Jeroen; Lakenberg, Nico; Arindrarto, Wibowo; Kielbasa, Szymon M.; Van 'T Hof, Peter; Nooren, Irene; Beekman, Marian; Deelen, Joris; Van Heemst, Diana; Zhernakova, Alexandra; Tigchelaar, Ettje F.; Swertz, Morris A.; Hofman, Bert A.; Uitterlinden, André G.; Pool, René; Van Dongen, Jenny; Hottenga, Jouke J.; Stehouwer, Coen D.A.; Van Der Kallen, Carla J.H.; Schalkwijk, Casper G.; Van Den Berg, Leonard H.; Van Zwet, Erik W.; Mei, Hailiang; Slagboom, P. Eline; Wijmenga, Cisca; Veldink, Jan H.; Van Greevenbroek, Marleen M.J.; Van Duijn, Cornelia M.; Boomsma, Dorret I.; Isaacs, Aaron; Jansen, Rick; Van Meurs, Joyce; Thoen, Peter A.C.; Franke, Lude; Heijmans, Bastiaan T.; Oosting, Jan; Van Doorn, Remco |
| Source: | Salgado, C, Gruis, N, Bonder, M J, Luijk, R, Zhernakova, D V, Moed, M, Deelen, P, Vermaat, M, Van Iterson, M, Van Dijk, F, Van Galen, M, Bot, J, Jhamai, P M, Verbiest, M, Suchiman, H E D, Verkerk, M, Van Der Breggen, R, Van Rooij, J, Lakenberg, N, Arindrarto, W, Kielbasa, S M, Van 'T Hof, P, Nooren, I, Beekman, M, Deelen, J, Van Heemst, D, Zhernakova, A, Tigchelaar, E F, Swertz, M A, Hofman, B A, Uitterlinden, A G, Pool, R, Van Dongen, J, Hottenga, J J, Stehouwer, C D A, Van Der Kallen, C J H, .... |
| Publication Year: | 2020 |
| Collection: | University of Groningen research database |
| Subject Terms: | DNA methylation; Epimutation; Familial melanoma; Loss of imprinting |
| Description: | Background: Heritable epigenetic alterations have been proposed as an explanation for familial clustering of melanoma. Here we performed genome-wide DNA methylation analysis on affected family members not carrying pathogenic variants in established melanoma susceptibility genes, compared with healthy volunteers. Results: All melanoma susceptibility genes showed the absence of epimutations in familial melanoma patients, and no loss of imprinting was detected. Unbiased genome-wide DNA methylation analysis revealed significantly different levels of methylation in single CpG sites. The methylation level differences were small and did not affect reported tumour predisposition genes. Conclusion: Our results provide no support for heritable epimutations as a cause of familial melanoma. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| ISSN: | 1868-7075; 1868-7083 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/32143689; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/11370/b63954c4-e935-4347-bf4e-2a8aada5382a; info:eu-repo/semantics/altIdentifier/pissn/1868-7075; info:eu-repo/semantics/altIdentifier/eissn/1868-7083 |
| DOI: | 10.1186/s13148-020-00831-7 |
| Availability: | https://hdl.handle.net/11370/b63954c4-e935-4347-bf4e-2a8aada5382a; https://research.rug.nl/en/publications/b63954c4-e935-4347-bf4e-2a8aada5382a; https://doi.org/10.1186/s13148-020-00831-7; https://www.scopus.com/pages/publications/85081258657 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.FD43F4A3 |
| Database: | BASE |