| Title: |
Efficacy and Nephrotoxicity of Extended versus Intermittent Infusion of Beta-Lactams for the Treatment of Ventilator Associated Pneumonia |
| Authors: |
Ali Rihan, Bassel Fathalla; Nashed, Sherif Wadie; Elagamy, Ashraf El Sayed; Hassan, Ramy Mohammed |
| Source: |
QJM: An International Journal of Medicine ; volume 117, issue Supplement_2 ; ISSN 1460-2725 1460-2393 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2024 |
| Description: |
Background Patients in the intensive care unit (ICU) are at risk for dying not only from their critical illness but also from secondary processes such as nosocomial infection. Pneumonia is the second most common nosocomial infection in critically ill patients. Eighty-six percent of nosocomial pneumonias are associated with mechanical ventilation and are termed ventilator- associated pneumonia (VAP). Ventilator-associated pneumonia is defined as pneumonia occurring more than 48 h after patients have been intubated and received mechanical ventilation. Diagnosing VAP requires a high clinical suspicion combined with bedside examination, radiographic examination, and microbiologic analysis of respiratory secretions. Aim of the Work to compare the Efficacy and nephrotoxicity of extended versus intermittent infusion of beta-lactams for the treatment of ventilator associated pneumonia. Patients and Methods This Retrospective cohort study has been held in Intensive Care Units in Ain Shams University Hospitals on critically ill patients with ventilator associated pneumonia after applying exclusion criteria, in the period from April 2023 till December 2023. After approval of Ethical & Research committee of Ain Shams University. Results The current study results compared between the extended infusion group and the intermittent infusion group based on bacterial eradication, statistically significant differences were observed. In the extended infusion group, 70.0% of patients achieved bacterial eradication, whereas in the intermittent infusion group, only 45.0% achieved bacterial eradication. The p-value for this comparison was 0.024, indicating statistical significance. These findings suggest that patients in the extended infusion group had a higher rate of bacterial eradication compared to those in the intermittent infusion group. This implies that extended infusion of beta-lactam antibiotics may be more effective in eliminating bacteria associated with ventilator-associated pneumonia. The current study results ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/qjmed/hcae175.028 |
| Availability: |
https://doi.org/10.1093/qjmed/hcae175.028; https://academic.oup.com/qjmed/article-pdf/117/Supplement_2/hcae175.028/60747216/hcae175.028.pdf |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.FD5AC418 |
| Database: |
BASE |