| Title: |
Th17 cells are associated with pathology in human schistosomiasis (43.24) |
| Authors: |
Larkin, Bridget; Mbow, Moustapha; Meurs, Lynn; Wammes, Linda; de Jong, Sanne; Labuda, Lucja; Smits, Hermelijn; Dieye, Tanaka; Polman, Katja; Mboup, Souleyman; Stadecker, Miguel; Yazdanbakhsh, Maria |
| Source: |
The Journal of Immunology ; volume 188, issue 1_Supplement, page 43.24-43.24 ; ISSN 0022-1767 1550-6606 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2012 |
| Description: |
Infection with parasitic helminths of the genus Schistosoma results in a wide range of immunopathology. Studies in murine schistosomiasis suggest that Th17 cells play a major role in the development of severe pathology; conversely, regulatory T (Treg) cells represent a mechanism to curtail excessive inflammation. We assessed by flow cytometry the profile of peripheral blood (PB) CD4 T cells in a cohort of children with urinary schistosomiasis from the village of Pakh, Department of Richard Toll, Senegal. S. hematobium-infected children with bladder pathology had a significantly higher percentage of PB IL-17+ cells with higher RORγt+/ Foxp3+ and IL-17+/ IL-10+ cell ratios than infected children without pathology. To investigate the relationship between PB values and target organs, we also examined the PB T cell response in murine S. mansoni infection (S. hematobium is non-permissive in mice) and, similar to humans, found a significantly higher percentage of CD4+ IL-17+ cells in high-pathology CBA mice than in low-pathology BL/6 mice. Moreover, a significant increase in IL-17+ cells in spleen and liver granulomas together with lower Foxp3+ cells in the spleen of CBA mice denoted a good correlation between PB and target organs. Our findings for the first time demonstrate an association between pathology and PB Th17 cells in human schistosomiasis and suggest human PB T cell subsets to faithfully reflect those mediating lesions in organs affected by the disease. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.4049/jimmunol.188.supp.43.24 |
| Availability: |
https://doi.org/10.4049/jimmunol.188.supp.43.24; https://academic.oup.com/jimmunol/article/188/1_Supplement/43.24/7980225 |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.FD645955 |
| Database: |
BASE |