| Title: |
DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases |
| Authors: |
Wielscher, M. (Matthias); Mandaviya, P. R. (Pooja R.); Kuehnel, B. (Brigitte); Joehanes, R. (Roby); Mustafa, R. (Rima); Robinson, O. (Oliver); Zhang, Y. (Yan); Bodinier, B. (Barbara); Walton, E. (Esther); Mishra, P. P. (Pashupati P.); Schlosser, P. (Pascal); Wilson, R. (Rory); Tsai, P.-C. (Pei-Chien); Palaniswamy, S. (Saranya); Marioni, R. E. (Riccardo E.); Fiorito, G. (Giovanni); Cugliari, G. (Giovanni); Karhunen, V. (Ville); Ghanbari, M. (Mohsen); Psaty, B. M. (Bruce M.); Loh, M. (Marie); Bis, J. C. (Joshua C.); Lehne, B. (Benjamin); Sotoodehnia, N. (Nona); Deary, I. J. (Ian J.); Chadeau-Hyam, M. (Marc); Brody, J. A. (Jennifer A.); Cardona, A. (Alexia); Selvin, E. (Elizabeth); Smith, A. K. (Alicia K.); Miller, A. H. (Andrew H.); Torres, M. A. (Mylin A.); Marouli, E. (Eirini); Gao, X. (Xin); van Meurs, J. B. (Joyce B. J.); Graf-Schindler, J. (Johanna); Rathmann, W. (Wolfgang); Koenig, W. (Wolfgang); Peters, A. (Annette); Weninger, W. (Wolfgang); Farlik, M. (Matthias); Zhang, T. (Tao); Chen, W. (Wei); Xia, Y. (Yujing); Teumer, A. (Alexander); Nauck, M. (Matthias); Grabe, H. J. (Hans J.); Doerr, M. (Macus); Lehtimaki, T. (Terho); Guan, W. (Weihua); Milani, L. (Lili); Tanaka, T. (Toshiko); Fisher, K. (Krista); Waite, L. L. (Lindsay L.); Kasela, S. (Silva); Vineis, P. (Paolo); Verweij, N. (Niek); van der Harst, P. (Pim); Iacoviello, L. (Licia); Sacerdote, C. (Carlotta); Panico, S. (Salvatore); Krogh, V. (Vittorio); Tumino, R. (Rosario); Tzala, E. (Evangelia); Matullo, G. (Giuseppe); Hurme, M. A. (Mikko A.); Raitakari, O. T. (Olli T.); Colicino, E. (Elena); Baccarelli, A. A. (Andrea A.); Kahonen, M. (Mika); Herzig, K.-H. (Karl-Heinz); Li, S. (Shengxu); BIOS consortium; Conneely, K. N. (Karen N.); Kooner, J. S. (Jaspal S.); Kottgen, A. (Anna); Heijmans, B. T. (Bastiaan T.); Deloukas, P. (Panos); Relton, C. (Caroline); Ong, K. K. (Ken K.); Bell, J. T. (Jordana T.); Boerwinkle, E. (Eric); Elliott, P. (Paul); Brenner, H. (Hermann); Beekman, M. (Marian); Levy, D. (Daniel); Waldenberger, M. (Melanie); Chambers, J. C. (John C.); Dehghan, A. (Abbas); Järvelin, M.-R. (Marjo-Riitta) |
| Publisher Information: |
Springer Nature |
| Publication Year: |
2022 |
| Collection: |
Jultika - University of Oulu repository / Oulun yliopiston julkaisuarkisto |
| Subject Terms: |
DNA methylation; Obesity; Risk factors |
| Description: |
We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1,511 independent differentially methylated loci associated with CRP. These CpG sites show correlation structures across chromosomes, and are primarily situated in euchromatin, depleted in CpG islands. These genomic loci are predominantly situated in transcription factor binding sites and genomic enhancer regions. Mendelian randomization analysis suggests altered CpG methylation is a consequence of increased blood CRP levels. Mediation analysis reveals obesity and smoking as important underlying driving factors for changed CpG methylation. Finally, we find that an activated CpG signature significantly increases the risk for cardiometabolic diseases and COPD. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/url/https://doi.org/10.6084/m9.figshare.19188674.v1 |
| Availability: |
http://urn.fi/urn:nbn:fi-fe2022110764776 |
| Rights: |
info:eu-repo/semantics/openAccess ; © The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.FD68DDA0 |
| Database: |
BASE |