| Title: |
Cumulative remnant cholesterol predicts cardiovascular outcomes in elderly patients with atherosclerotic cardiovascular disease |
| Authors: |
Xiao, Zhiwen; Lin, Zhongqiu; Xu, Lin; Xu, Wenlong; Huang, Haoxiang; Wang, Yuegang; Cao, Shiping; Xie, Zhiquan; Liao, Wangjun; Liao, Yulin; Bin, Jianping; Feng, Weijing; Chen, Yanmei |
| Contributors: |
National Natural Science Foundation of China; GuangDong Basic and Applied Basic Research Foundation; China Postdoctoral Science Foundation; Foundation of General Hospital of Southern Theater Command |
| Source: |
European Journal of Preventive Cardiology ; volume 30, issue 17, page 1924-1934 ; ISSN 2047-4873 2047-4881 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2023 |
| Description: |
Aims Remnant cholesterol (RC) reportedly mediates residual cardiovascular risk in atherosclerotic cardiovascular diseases (ASCVD). However, few studies have characterized long-term cumulative RC exposure among elderly people. The study aimed to evaluate the association between cumulative exposure to RC and incident major adverse cardiovascular events (MACE) by analysing a cohort of elderly patients with ASCVD. Methods and results This retrospective multicentre cohort study enrolled ASCVD participants aged ≥75 years with baseline visits occurring from 2006 to 2012 followed by four in-person visits. Cumulative RC was estimated as the area under the curve using measurements from the first to fourth visits by using 9-year data. The time-weighted average (TWA) RC was expressed as cumulative exposure to RC averaged by years. All outcomes were follow-up from the fourth visit to the year 2021. Outcomes included a composite of MACE (stroke, unstable angina pectoris, myocardial infarction, and cardiac death). We included 4,680 participants (73.1% male, mean age 79.3 ± 2.5 years). The median follow-up duration was 6.1 years (interquartile range: 3.4–6.6 years). In the multivariable model adjusted for traditional cardiovascular risk factors, low-density lipoprotein cholesterol level, and most recent RC level, the hazard ratios for MACE that compared the high and low tertiles of the RC variables were 1.30 [95% confidence interval (CI), 1.16–1.44] for cumulative RC and 1.36 (95% CI, 1.23–1.52) for TWA RC. Consistent significant associations were observed among most propensity score analyses. Conclusions Long-term cumulative RC was independently associated with incident MACE in elderly participants with ASCVD, suggesting that achieving and maintaining optimal RC levels later in life may still improve cardiovascular outcomes. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/eurjpc/zwad297 |
| DOI: |
10.1093/eurjpc/zwad297/51930189/zwad297.pdf |
| Availability: |
https://doi.org/10.1093/eurjpc/zwad297; https://academic.oup.com/eurjpc/advance-article-pdf/doi/10.1093/eurjpc/zwad297/51930189/zwad297.pdf; https://academic.oup.com/eurjpc/article-pdf/30/17/1924/53799435/zwad297.pdf |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.FDA05CC9 |
| Database: |
BASE |