| Title: |
Antiretroviral-naive and -treated HIV-1 patients can harbour more resistant viruses in CSF than in plasma |
| Authors: |
Soulie, Cathia; Descamps, Diane; Grudé, Maxime; Schneider, Véronique; Trabaud, Mary-Anne; Morand-Joubert, Laurence; Delaugerre, Constance; Montes, Brigitte; Barin, Francis; Ferre, Virginie; Raymond, Stéphanie; Jeulin, Hélène; Alloui, Chakib; Yerly, Sabine; Pallier, Coralie; Reigadas, Sandrine; Signori-Schmuck, Anne; Guigon, Aurélie; Fafi-Kremer, Samira; Haïm-Boukobza, Stéphanie; Mirand, Audrey; Maillard, Anne; Vallet, Sophie; Roussel, Catherine; Assoumou, Lambert; Calvez, Vincent; Flandre, Philippe; Marcelin, Anne-Geneviève; on behalf of the ANRS Resistance AC11 Group; Lagier, E.; Roussel, C.; Le Guillou, H.; Alloui, C.; Bettinger, D.; Pallier, C.; Fleury, H.; Reigadas, S.; Bellecave, P.; Recordon-Pinson, P.; Payan, C.; Vallet, S.; Vabret, A.; Henquell, C.; Mirand, A.; Bouvier-Alias, M.; de Rougemont, A.; Dos Santos, G.; Morand, P.; Signori-Schmuck, A.; Bocket, L.; Rogez, S.; Andre, P.; Tardy, J.C.; Trabaud, M.A.; Tamalet, C.; Delamare, C.; Montes, B.; Schvoerer, E.; Ferre, V.; André-Garnier, E.; Cottalorda, J.; Guinard, J.; Guiguon, A.; Descamps, D.; Brun-Vézinet, F.; Charpentier, C.; Visseaux, B.; Peytavin, G.; Krivine, A.; Si-Mohamed, A.; Avettand-Fenoel, V.; Marcelin, A.G.; Calvez, V.; Lambert-Niclot, S.; Soulié, C.; Wirden, M.; Morand-Joubert, L.; Delaugerre, C.; Chaix, M.L.; Amiel, C.; Schneider, V.; Giraudeau, G.; Brodard, V.; Maillard, A.; Plantier, J.C.; Chaplain, C.; Bourlet, T.; Fafi-Kremer, S.; Stoll-Keller, F.; Schmitt, M.P.; Barth, H.; Yerly, S.; Poggi, C.; Izopet, J.; Raymond, S.; Barin, F.; Chaillon, A.; Marque-Juillet, S.; Roque-Afonso, A.M.; Haïm-Boukobza, S.; Flandre, P.; Grudé, M.; Assoumou, L.; Costagliola, D.; Allegre, T.; Schmit, J.L.; Chennebault, J. M.; Bouchaud, O.; Magy-Bertrand, N.; Delfraissy, J.F.; Dupon, M.; Morlat, P.; Neau, D.; Ansart, S.; Jaffuel, S.; Verdon, R.; Jacomet, C.; Lévy, Y.; Dominguez, S.; Chavanet, P.; Piroth, L.; Cabié, A.; Leclercq, P.; Ajana, F.; Cheret, A.; Weinbreck, P.; Cotte, L.; Poizot-Martin, I.; Ravaud, I.; Christian, B.; Truchetet, F.; Grandidier, M.; Reynes, J.; May, T.; Goehringer, F.; Raffi, F.; Dellamonica, P.; Prazuck, T.; Hocqueloux, L.; Yéni, P.; Landman, R.; Launay, O.; Weiss, L.; Viard, J.P.; Katlama, C.; Simon, A.; Girard, P.M.; Meynard, J.L.; Molina, J.M.; Pialoux, G.; Hoen, B.; Goeger-Sow, M.T.; Lamaury, I.; Beaucaire, G.; Jaussaud, R.; Rouger, C.; Michelet, C.; Borsa-Lebas, F.; Caron, F.; Khuong, M.A.; Lucht, F.; Rey, D.; Calmy, A.; Marchou, B.; Gras, G.; Greder-Belan, A.; Vittecoq, D.; Teicher, E. |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2014 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Original research |
| Description: |
Objectives The neurological disorders in HIV-1-infected patients remain prevalent. The HIV-1 resistance in plasma and CSF was compared in patients with neurological disorders in a multicentre study. Methods Blood and CSF samples were collected at time of neurological disorders for 244 patients. The viral loads were >50 copies/mL in both compartments and bulk genotypic tests were realized. Results On 244 patients, 89 and 155 were antiretroviral (ARV) naive and ARV treated, respectively. In ARV-naive patients, detection of mutations in CSF and not in plasma were reported for the reverse transcriptase (RT) gene in 2/89 patients (2.2%) and for the protease gene in 1/89 patients (1.1%). In ARV-treated patients, 19/152 (12.5%) patients had HIV-1 mutations only in the CSF for the RT gene and 30/151 (19.8%) for the protease gene. Two mutations appeared statistically more prevalent in the CSF than in plasma: M41L ( P = 0.0455) and T215Y ( P = 0.0455). Conclusions In most cases, resistance mutations were present and similar in both studied compartments. However, in 3.4% of ARV-naive and 8.8% of ARV-treated patients, the virus was more resistant in CSF than in plasma. These results support the need for genotypic resistance testing when lumbar puncture is performed. |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://jac.oxfordjournals.org/cgi/content/short/dku419v1; http://dx.doi.org/10.1093/jac/dku419 |
| DOI: |
10.1093/jac/dku419 |
| Availability: |
http://jac.oxfordjournals.org/cgi/content/short/dku419v1; https://doi.org/10.1093/jac/dku419 |
| Rights: |
Copyright (C) 2014, The British Society for Antimicrobial Chemotherapy |
| Accession Number: |
edsbas.FE0E2C38 |
| Database: |
BASE |