| Title: |
Exploiting azide-alkyne click chemistry in the synthesis, tracking and targeting of platinum anticancer complexes. |
| Authors: |
Farrer, NJ; Griffith, DM |
| Publisher Information: |
Elsevier |
| Publication Year: |
2020 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Click chemistry is fundamentally important to medicinal chemistry and chemical biology. It represents a powerful and versatile tool, which can be exploited to develop novel Pt-based anticancer drugs and to better understand the biological effects of Pt-based anticancer drugs at a cellular level. Innovative azide–alkyne cycloaddition–based approaches are being used to functionalise Pt-based complexes with biomolecules to enhance tumour targeting. Valuable information in relation to the mechanisms of action and resistance of Pt-based drugs is also being revealed through click-based detection, isolation and tracking of Pt drug surrogates in biological and cellular environments. Although less well-explored, inorganic Pt-click reactions enable synthesis of novel (potentially multimetallic) Pt complexes and provide plausible routes to introduce functional groups and monitoring Pt-azido drug localisation. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1016/j.cbpa.2019.12.001 |
| DOI: |
10.1016/j.cbpa.2019.12.001 |
| Availability: |
https://doi.org/10.1016/j.cbpa.2019.12.001; https://ora.ox.ac.uk/objects/uuid:1d5b8242-8a18-4705-91a5-d28fa78fcd3c |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.FE19504C |
| Database: |
BASE |