| Title: |
TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMPZQ variants |
| Authors: |
Rohr, Claudia, M.; Park, Sang-Kyu; Aguiar-Martins, Kelsilandia; Anderson, Timothy, J.C.; Berger, Duncan, J.; Berriman, Matthew; Buddenborg, Sarah, K.; Bustinduy, Amaya, L.; Chevalier, Frédéric, D.; Cotton, James, A.; Crellen, Thomas; Doyle, Stephen, R.; Emery, Aidan, M.; Kincaid Smith, Julien; Kinung'Hi, Safari; Lamberton, Poppy, H.L.; Le Clec’h, Winka; Ndombi, Eric; Pennance, Tom; Rowel, Candia; Summers, Shannan, S.; Tushabe, John, Vianney; Walker, Martin; Webster, Bonnie, L.; Webster, Joanne, P.; Wilson, Shona; Marchant, Jonathan, S. |
| Contributors: |
Medical College of Wisconsin Milwaukee (MCW); Department of Pathobiology and Population Sciences; Royal Veterinary College (RVC); University of London London -University of London London; Texas Biomedical Research Institute San Antonio, TX; The Wellcome Trust Sanger Institute Cambridge; University of Glasgow; College of Veterinary Medicine and Life Sciences; London School of Hygiene and Tropical Medicine (LSHTM); National University of Singapore (NUS); Saw Swee Hock School of Public Health; The Natural History Museum London (NHM); Centre de Biologie pour la Gestion des Populations (UMR CBGP); Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD Occitanie )-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier; Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM); National Institute for Medical Research Tanzania (NIMR); Kenya Medical Research Institute (KEMRI); Kenyatta University of Nairobi (KU); Ministry of Health Uganda; Department of Infectious Disease Epidemiology London (DIDE); Imperial College London; University of Cambridge Cambridge, UK (CAM); Research was supported by the National Institutes of Health R01-AI145871 (to JSM), F31-AI183573 (to CMR), R01-AI123434 (to TJCA), R01-AI160433 (to EN). The FibroScHot project is part of the EDCTP2 programme supported by the European Union (RIA2017NIM-1842-FibroScHot). Collections associated with the Natural History Museum (NHM) in London, were supported by: EU grant CONTRAST (FP6 STREP contract no: 032203), NHM internal funds, and the Schistosomiasis Collection at the NHM (SCAN; Wellcome Trust biomedical resource project, 104958/Z/14/Z). The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) program was funded by the University of Georgia Research Foundation, Inc., which was funded by the Bill & Melinda Gates with the collections funded via sub-awards RR374-053/5054146; RR374-053/4785426 . Other sample collections were supported by the Gates Foundation (INV-048412 to TJCA) and the MERCK Schistosomiasis Research Grant Initiative (To EN). |
| Source: |
ISSN: 2211-3207 ; International journal for parasitology. Drugs and drug resistance ; https://hal.inrae.fr/hal-05576150 ; International journal for parasitology. Drugs and drug resistance, 2026, 30, pp.100639. ⟨10.1016/j.ijpddr.2026.100639⟩ ; https://www.sciencedirect.com/science/article/pii/S2211320726000096. |
| Publisher Information: |
CCSD; Elsevier |
| Publication Year: |
2026 |
| Collection: |
Université de Montpellier: HAL |
| Subject Terms: |
Resistance; Transient receptor potential channel; Schistosomiasis; Database; [INFO.INFO-DB]Computer Science [cs]/Databases [cs.DB]; [SDV.BBM]Life Sciences [q-bio]/Biochemistry; Molecular Biology; [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry; Molecular Biology/Genomics [q-bio.GN]; [SDV.BC]Life Sciences [q-bio]/Cellular Biology; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology; [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; [QFIN.RM]Quantitative Finance [q-fin]/Risk Management [q-fin.RM] |
| Description: |
International audience ; Highlights: • A community resource that catalogues natural variation within the ion channel, TRPMPZQ. • Praziquantel sensitivity, and expression levels of TRPMPZQ variants, are assessed in mammalian cells. • Data will aid surveillance of TRPMPZQ variants that may impact clinical PZQ sensitivity.Abstract: The anthelmintic praziquantel (PZQ) has been used for decades as the clinical therapy for schistosomiasis, and remains the only available drug. As a cheap and effective drug therapy for all human disease-causing Schistosoma species, usage of PZQ underpins mass drug administration strategies aimed at eliminating schistosomiasis as a public health problem by 2030. Concern over the potential emergence of resistance to PZQ is therefore warranted, as it would constitute a major threat to this approach. In terms of molecular adaptations conferring PZQ resistance, variation in the sequence and/or expression of the drug target is an obvious mechanism and should be a priority for surveillance efforts. The target of PZQ is a transient receptor potential ion channel, TRPMPZQ, which is established as a locus that regulates schistosome sensitivity to PZQ. Here, we describe the establishment of a community resource, ‘TRPtracker’, which coalesces data on TRPMPZQ natural variants together with measurements of individual TRPMPZQ variant sensitivity to PZQ assessed by profiling TRPMPZQ in a heterologous expression system. A compendium of laboratory-generated mutants in TRPMPZQ is also compiled in the TRPtracker database to delimit regions within TRPMPZQ that are critical for PZQ sensitivity. Aggregation of data from multiple research groups into TRPtracker catalogues which TRPMPZQ variants have been functionally profiled, where geographically these variants have been found, their frequency within populations, and their potential impact on PZQ sensitivity. The overall goal is to facilitate rapid community-wide exchange of data to monitor predicted variants of concern that are likely to be associated with ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41865684; PUBMED: 41865684 |
| DOI: |
10.1016/j.ijpddr.2026.100639 |
| Availability: |
https://hal.inrae.fr/hal-05576150; https://hal.inrae.fr/hal-05576150v1/document; https://hal.inrae.fr/hal-05576150v1/file/1-s2.0-S2211320726000096-main.pdf; https://doi.org/10.1016/j.ijpddr.2026.100639 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.FE1D138D |
| Database: |
BASE |