| Title: |
Medication prescription and adherence disparities in non valvular atrial fibrillation patients: an Italian portrait from the ARAPACIS study. |
| Authors: |
Raparelli V; Proietti M; Buttà C; Di Giosia P; Sirico D; Gobbi P; Corrao S; Vestri AR; Perticone F; Corazza GR; Violi F; Basili S; ARAPACIS Study Investigators; GIS Group; DAVI', Giovanni |
| Contributors: |
Raparelli, V; Proietti, M; Buttà, C; Di Giosia, P; Sirico, D; Gobbi, P; Corrao, S; Davi', Giovanni; Vestri, Ar; Perticone, F; Corazza, Gr; Violi, F; Basili, S; ARAPACIS Study, Investigator; Gis, Group |
| Publication Year: |
2014 |
| Collection: |
ARUd'A - Archivio Istituzionale della ricerca dell'università Chieti-Pescara (IRIS) |
| Description: |
Non-valvular atrial fibrillation (NVAF) represents a major health-care problem, needing an extensive and strict thrombosis prevention for stroke and cardiovascular (CV) disease risks. NVAF management guidelines recommend adequate antithrombotic and anti-atherosclerotic therapies. Medication adherence has been recognized as a pivotal element in health quality promotion and in the achievement of better clinical outcomes. We conducted a post-hoc analysis of the "Atrial fibrillation Registry for Ankle-brachial index Prevalence Assessment-Collaborative Italian Study (ARAPACIS)" with the aim of discerning differences in pharmacological management and medication adherence among NVAF Italian patients. Furthermore, data were analysed according to Italian geographical macro-regions (North, Center, South) to evaluate whether socioeconomic conditions might also influence medication adherence. Thus, we selected 1,366 NVAF patients that fulfilled the Morisky Medication Adherence Scale-4 items. Regional disparities in drug prescriptions were observed. In particular, in high-risk patients (CHA2DS2-VASc ≥2) oral anticoagulants were more prescribed in Northern and Center patients (61 and 60 %, respectively) compared to 53 % of high-risk Southern patients. Also, medication adherence showed a progressive decrease from North to South (78 vs. 60 %, p < 0.001). This disparity was independent of the number of drugs consumed for any reason, since prevalence of poly-therapy among the three macro-regions was similar. Our results show regional differences in NVAF patients' antithrombotic management and medication adherence, potentially reflecting well-known disparities in socioeconomic status among Italian regions. Future interventions promoting campaigns to global health-care education may be desirable to improve clinical outcomes in NVAF patients. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:000345407800006; volume:9; issue:8; firstpage:861; lastpage:870; numberofpages:10; journal:INTERNAL AND EMERGENCY MEDICINE; https://hdl.handle.net/11564/605121 |
| DOI: |
10.1007/s11739-014-1096-1 |
| Availability: |
https://hdl.handle.net/11564/605121; https://doi.org/10.1007/s11739-014-1096-1 |
| Accession Number: |
edsbas.FE304F53 |
| Database: |
BASE |