| Title: |
Multi-faceted intervention to improve management of antibiotics for children presenting to primary care with acute cough and respiratory tract infection (CHICO): efficient cluster randomised controlled trial |
| Authors: |
Blair, Peter S.; Young, Grace; Clement, Clare; Dixon, P.; Seume, Penny; Ingram, Jenny; Taylor, Jodi; Cabral, Christie; Lucas, Patricia J.; Beech, Elizabeth; Horwood, Jeremy; Gulliford, Martin; Francis, Nick A.; Creavin, Sam; Lane, Janet A.; Bevan, Scott; Hay, Alistair D. |
| Publisher Information: |
BMJ Publishing Group |
| Publication Year: |
2023 |
| Collection: |
University of the West of England, Bristol: UWE Research Repository |
| Description: |
Objective: To assess whether an easy-to-use multifaceted intervention for children presenting to primary care with respiratory tract infections would reduce antibiotic dispensing, without increasing hospital admissions for respiratory tract infection. Design: Two arm randomised controlled trial clustered by general practice, using routine outcome data, with qualitative and economic evaluations. Setting: English primary care practices using the EMIS electronic medical record system. Participants: Children aged 0-9 years presenting with respiratory tract infection at 294 general practices, before and during the covid-19 pandemic. Intervention: Elicitation of parental concerns during consultation; a clinician focused prognostic algorithm to identify children at very low, normal, or elevated 30 day risk of hospital admission accompanied by antibiotic prescribing guidance; and a leaflet for carers including safety netting advice. Main outcome measures: Rate of dispensed amoxicillin and macrolide antibiotics (superiority comparison) and hospital admissions for respiratory tract infection (non-inferiority comparison) for children aged 0-9 years over 12 months (same age practice list size as denominator). Results: Of 310 practices needed, 294 (95%) were randomised (144 intervention and 150 controls) representing 5% of all registered 0-9 year olds in England. Of these, 12 (4%) subsequently withdrew (six owing to the pandemic). Median intervention use per practice was 70 (by a median of 9 clinicians). No evidence was found that antibiotic dispensing differed between intervention practices (155 (95% confidence interval 138 to 174) items/year/1000 children) and control practices (157 (140 to 176) items/year/1000 children) (rate ratio 1.011, 95% confidence interval 0.992 to 1.029; P=0.25). Pre-specified subgroup analyses suggested reduced dispensing in intervention practices with fewer prescribing nurses, in single site (compared with multisite) practices, and in practices located in areas of lower socioeconomic deprivation, ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0959-8138 |
| Relation: |
https://uwe-repository.worktribe.com/file/12084493/1/Multi-faceted%20intervention%20to%20improve%20management%20of%20antibiotics%20for%20children%20presenting%20to%20primary%20care%20with%20acute%20cough%20and%20respiratory%20tract%20infection%20%28CHICO%29%3A%20efficient%20cluster%20randomised%20controlled%20trial; https://uwe-repository.worktribe.com/output/12084493 |
| Availability: |
https://uwe-repository.worktribe.com/output/12084493 |
| Rights: |
openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.FE4CD1EB |
| Database: |
BASE |