| Title: |
Effects of Vitamin D and K on Interleukin-6 in COVID-19 |
| Authors: |
Visser, M.P.J.; Dofferhoff, A.S.M.; van den Ouweland, J.M.W.; van Daal, H.; Kramers, C.; Schurgers, L.J.; Janssen, R.; Walk, J. |
| Source: |
Visser, M P J, Dofferhoff, A S M, van den Ouweland, J M W, van Daal, H, Kramers, C, Schurgers, L J, Janssen, R & Walk, J 2022, 'Effects of Vitamin D and K on Interleukin-6 in COVID-19', Frontiers in nutrition, vol. 8, 761191. https://doi.org/10.3389/fnut.2021.761191 |
| Publication Year: |
2022 |
| Collection: |
Maastricht University Research Publications |
| Subject Terms: |
COVID-19; desmosine; dp-ucMGP; vitamin D; vitamin K; IL-6; 25-hydroxyvitamin D; NF-KAPPA-B; PROTEIN-S; CALCIFICATION; PATHWAY; CELLS |
| Description: |
BackgroundPathology during COVID-19 infection arises partly from an excessive inflammatory response with a key role for interleukin (IL)-6. Both vitamin D and K have been proposed as potential modulators of this process. MethodsWe assessed vitamin D and K status by measuring circulating 25-hydroxyvitamin D (25(OH)D) and desphospho-uncarboxylated Matrix Gla-Protein (dp-ucMGP), respectively in 135 hospitalized COVID-19 patients in relation to inflammatory response, elastic fiber degradation and clinical outcomes. ResultsComparing good and poor disease outcomes of COVID-19 patients, vitamin 25(OH)D levels were not significantly different. IL-6 levels, however, were significantly higher in patients with poor outcome, compared to patients with good outcome (30.3 vs. 153.0 pg/mL; p < 0.0001). Dp-ucMGP levels as biomarker of extrahepatic vitamin K status was associated with IL-6 levels (r = 0.35; p < 0.0001). In contrast, 25(OH)D levels were only borderline statistically significant correlated with IL-6 (r = -0.14; p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
2296-861X |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35111793; info:eu-repo/semantics/altIdentifier/wos/000750083000001; info:eu-repo/semantics/altIdentifier/pissn/2296-861X; info:eu-repo/semantics/reference/pmid/35356738; info:eu-repo/semantics/reference/wos/000783171700001 |
| DOI: |
10.3389/fnut.2021.761191 |
| Availability: |
https://cris.maastrichtuniversity.nl/en/publications/67622cc3-1543-408a-b7c3-d96ce1854481; https://doi.org/10.3389/fnut.2021.761191 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.FE5378E9 |
| Database: |
BASE |