| Title: |
External validation of the PAGE-B score for HCC risk prediction in people living with HIV/HBV coinfection |
| Authors: |
Surial, B; Ramírez Mena, A; Roumet, M; Limacher, A; Smit, C; Leleux, O; Mocroft, A; van der Valk, M; Bonnet, F; Peters, L; Rockstroh, JK; Günthard, HF; Berzigotti, A; Rauch, A; Wandeler, G; Abela, I; Aebi-Popp, K; Anagnostopoulos, A; Battegay, M; Bernasconi, E; Braun, DL; Bucher, HC; Calmy, A; Cavassini, M; Ciuffi, A; Dollenmaier, G; Egger, M; Elzi, L; Fehr, J; Fellay, J; Furrer, H; Fux, CA; Hachfeld, A; Haerry, D; Hasse, B; Hirsch, HH; Hoffmann, M; Hösli, I; Huber, M; Jackson-Perry, D; Kahlert, CR; Kaiser, L; Keiser, O; Klimkait, T; Kouyos, RD; Kovari, H; Kusejko, K; Labhardt, N; Leuzinger, K; de Tejada B, M; Marzolini, C; Metzner, KJ; Müller, N; Nemeth, J; Nicca, D; Notter, J; Paioni, P; Pantaleo, G; Perreau, M; Salazar-Vizcaya, L; Schmid, P; Speck, R; Stöckle, M; Tarr, P; Trkola, A; Weisser, M; Yerly, S; Geerlings, SE; Goorhuis, A; Harris, VC; Hovius, JW; Lempkes, B; Nellen, FJB; van der Poll, T; Prins, JM; Spoorenberg, V; van Vugt, M; Wiersinga, WJ; Wit, FWMN; Bruins, C; van Eden, J; Hylkema-van den Bout, IJ; van Hes, AMH; Pijnappel, FJJ; Smalhout, SY; Weijsenfeld, AM; Back, NKT; Berkhout, B; Cornelissen, MTE; van Houdt, R; Jonges, M; Jurriaans, S; Schinkel, CJ; Wolthers, KC; Zaaijer, HL; Peters, EJG |
| Source: |
Journal of Hepatology , 78 (5) pp. 947-957. (2023) (In press). |
| Publisher Information: |
Elsevier BV |
| Publication Year: |
2023 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
HIV infection; Hepatitis B virus; hepatocellular carcinoma; liver cirrhosis; liver neoplasms; model validation; risk assessment; risk prediction models; tenofovir |
| Description: |
Background & Aims: HBV coinfection is common among people living with HIV (PLWH) and is the most important cause of hepatocellular carcinoma (HCC). While risk prediction tools for HCC have been validated in patients with HBV monoinfection, they have not been evaluated in PLWH. Thus, we performed an external validation of PAGE-B in people with HIV/HBV coinfection. Methods: We included data on PLWH from four European cohorts who were positive for HBsAg and did not have HCC before starting tenofovir. We estimated the predictive performance of PAGE-B for HCC occurrence over 15 years in patients receiving tenofovir-containing antiretroviral therapy. Model discrimination was assessed after multiple imputation using Cox regression with the prognostic index as a covariate, and by calculating Harrell's c-index. Calibration was assessed by comparing our cumulative incidence with the PAGE-B derivation study using Kaplan-Meier curves. Results: In total, 2,963 individuals with HIV/HBV coinfection on tenofovir-containing antiretroviral therapy were included. PAGE-B was |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10168869/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10168869/1/1-s2.0-S0168827823000119-main.pdf; https://discovery.ucl.ac.uk/id/eprint/10168869/ |
| Rights: |
open |
| Accession Number: |
edsbas.FEE0F7DB |
| Database: |
BASE |