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Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.

Title:	Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
Authors:	AE Justice; T Karaderi; HM Highland; KL Young; M Graff; Y Lu; V Turcot; PL Auer; RS Fine; X Guo; C Schurmann; A Lempradl; E Marouli; A Mahajan; TW Winkler; AE Locke; C Medina-Gomez; T Esko; S Vedantam; A Giri; KS Lo; T Alfred; P Mudgal; MCY Ng; NL Heard-Costa; MF Feitosa; AK Manning; SM Willems; S Sivapalaratnam; G Abecasis; DS Alam; M Allison; P Amouyel; Z Arzumanyan; B Balkau; L Bastarache; S Bergmann; LF Bielak; M Blüher; M Boehnke; H Boeing; E Boerwinkle; CA Böger; J Bork-Jensen; EP Bottinger; DW Bowden; I Brandslund; L Broer; AA Burt; AS Butterworth; MJ Caulfield; G Cesana; JC Chambers; DI Chasman; Y-DI Chen; R Chowdhury; C Christensen; AY Chu; FS Collins; JP Cook; AJ Cox; DS Crosslin; J Danesh; PIW de Bakker; SD Denus; RD Mutsert; G Dedoussis; EW Demerath; JG Dennis; JC Denny; ED Angelantonio; M Dörr; F Drenos; M-P Dubé; AM Dunning; DF Easton; P Elliott; E Evangelou; A-E Farmaki; S Feng; E Ferrannini; J Ferrieres; JC Florez; M Fornage; CS Fox; PW Franks; N Friedrich; W Gan; I Gandin; P Gasparini; V Giedraitis; G Girotto; M Gorski; H Grallert; N Grarup; ML Grove; S Gustafsson; J Haessler; T Hansen; AT Hattersley; C Hayward; IM Heid; OL Holmen; GK Hovingh; JMM Howson; Y Hu; Y-J Hung; K Hveem; MA Ikram; E Ingelsson; AU Jackson; GP Jarvik; Y Jia; T Jørgensen; P Jousilahti; JM Justesen; B Kahali; M Karaleftheri; SLR Kardia; F Karpe; F Kee; H Kitajima; P Komulainen; JS Kooner; P Kovacs; BK Krämer; K Kuulasmaa; J Kuusisto; M Laakso; TA Lakka; D Lamparter; LA Lange; C Langenberg; EB Larson; NR Lee; W-J Lee; T Lehtimäki; CE Lewis; H Li; J Li; R Li-Gao; L-A Lin; X Lin; L Lind; J Lindström; A Linneberg; C-T Liu; DJ Liu; J Luan; L-P Lyytikäinen; S MacGregor; R Mägi; S Männistö; G Marenne; J Marten; NGD Masca; MI McCarthy; K Meidtner; E Mihailov; L Moilanen; M Moitry; DO Mook-Kanamori; A Morgan; AP Morris; M Müller-Nurasyid; PB Munroe; N Narisu; CP Nelson; M Neville; I Ntalla; JR O'Connell; KR Owen; O Pedersen; GM Peloso; CE Pennell; M Perola; JA Perry; JRB Perry; TH Pers; A Ewing; O Polasek; OT Raitakari; A Rasheed; CK Raulerson; R Rauramaa; DF Reilly; AP Reiner; PM Ridker; MA Rivas; NR Robertson; A Robino; I Rudan; KS Ruth; D Saleheen; V Salomaa; NJ Samani; PJ Schreiner; MB Schulze; RA Scott; M Segura-Lepe; X Sim; AJ Slater; KS Small; BH Smith; JA Smith; L Southam; TD Spector; EK Speliotes; K Stefansson; V Steinthorsdottir; KE Stirrups; K Strauch; HM Stringham; M Stumvoll; L Sun; P Surendran; KMA Swart; J-C Tardif; KD Taylor; A Teumer; DJ Thompson; G Thorleifsson; U Thorsteinsdottir; BH Thuesen; A Tönjes; M Torres; E Tsafantakis; J Tuomilehto; AG Uitterlinden; M Uusitupa; CM van Duijn; M Vanhala; R Varma; SH Vermeulen; H Vestergaard; V Vitart; TF Vogt; D Vuckovic; LE Wagenknecht; M Walker; L Wallentin; F Wang; CA Wang; S Wang; NJ Wareham; HR Warren; DM Waterworth; J Wessel; HD White; CJ Willer; JG Wilson; AR Wood; Y Wu; H Yaghootkar; J Yao; LM Yerges-Armstrong; R Young; E Zeggini; X Zhan; W Zhang; JH Zhao; W Zhao; H Zheng; W Zhou; MC Zillikens; CHD Exome+ Consortium; Cohorts for Heart and Aging Research in Genomic Epidemiology; EPIC-CVD Consortium; ExomeBP Consortium; Global Lipids Genetic Consortium; GoT2D Genes Consortium; InterAct; ReproGen Consortium; T2D-Genes Consortium; MAGIC Investigators; F Rivadeneira; IB Borecki; JA Pospisilik; P Deloukas; TM Frayling; G Lettre; KL Mohlke; JI Rotter; Z Kutalik; JN Hirschhorn; LA Cupples; RJF Loos; KE North; CM Lindgren
Publication Year:	2019
Collection:	University of Leicester: Figshare
Subject Terms:	Genetic association study; Genetics research
Description:	Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF
Document Type:	article in journal/newspaper
Language:	unknown
Relation:	2381/43842
Availability:	https://figshare.com/articles/journal_contribution/Protein-coding_variants_implicate_novel_genes_related_to_lipid_homeostasis_contributing_to_body-fat_distribution_/10199750
Rights:	All Rights Reserved
Accession Number:	edsbas.FF1E580E
Database:	BASE