| Title: |
Valproate, Carnitine Metabolism, and Biochemical Indicators of Liver Function |
| Authors: |
Beghi, Ettore; Bizzi, Adalgisa; Codegoni, Anna Maria; Trevisan, Daniela; Torri, Walter |
| Source: |
Epilepsia ; volume 31, issue 3, page 346-352 ; ISSN 0013-9580 1528-1167 |
| Publisher Information: |
Wiley |
| Publication Year: |
1990 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Summary: The effects of valproate (VPA) on carnitine and lipid metabolism and on liver function were assessed in 213 age‐ and sex‐matched outpatients from five centers, with the following distribution: VPA monotherapy, 54; VPA polytherapy, 55; other monotherapies, 51; and untreated, 53. Mean total and free carnitine levels were significantly lower in patients with polytherapy; acylcar‐nitine was significantly higher for VPA monotherapy and the ratio of acyl‐ to free carnitine was significantly higher in all patients receiving VPA. Ammonia, uric acid, and bilirubin were the only tests selectively impaired with VPA. A significant correlation was found between serum ammonia and VPA dosage. Glucose, B‐lipoproteins, try‐glicerides, acetacetate, and p‐hydroxybutyrate were unchanged in the four groups. Sex and age appeared to interact with total and free carnitine values. Adverse drug reactions were apparently unrelated to carnitine metabolism impairment. Only a few patients had abnormal carnitine values. Our data support the assumption that carnitine deficiency and abnormal liver function due to VPA are mostly subclinical events. RÉSUMÉ Les effets du valproate (VPA) sur le métabolisme de la carnitine, le métabolisme lipidique et le fonctionnement hépatique ont étéévalués chez 213 patients ambulatoires appariés pour l'âge et pour le sexe et provenant de 5 centres différents, répartis dans les groupes suivants: monothérapie par VPA, 54; polythérapie incluant le VPA, 55; autres monothérapies, 51; non traités, 53. Les taux moyens de carnitine totale et libre ont été significativement dimimiés chez les patients sous polythérapie. L'acyl‐carnitine était significativement plus élevée sous monothérapie par VPA, et le rapport acyl‐carnitine/carnitine libre était plus élevé chez les patients recevant du VPA. L'amnoniémie, l'uricémie et la bilirubinémie ont été les seuls paramètres modifyés sélectivement par le VPA. Une corrélation significative a été constatée entre l'amnoniémie et le taux sanguin de VPA. II n'y a pas eu de ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/j.1528-1157.1990.tb05387.x |
| Availability: |
https://doi.org/10.1111/j.1528-1157.1990.tb05387.x; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1528-1157.1990.tb05387.x; https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1528-1157.1990.tb05387.x |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.FF26DF64 |
| Database: |
BASE |