| Title: |
Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants |
| Authors: |
Noordam, Raymond; Wang, Wenyi; Nagarajan, Pavithra; Wang, Heming; Brown, Michael R; Bentley, Amy R; Hui, Qin; Kraja, Aldi T; Morrison, John L; O'Connel, Jeffrey R; Lee, Songmi; Schwander, Karen; Bartz, Traci M; de Las Fuentes, Lisa; Feitosa, Mary F; Guo, Xiuqing; Hanfei, Xu; Harris, Sarah E; Huang, Zhijie; Kals, Mart; Lefevre, Christophe; Mangino, Massimo; Milaneschi, Yuri; van der Most, Peter J; Pacheco, Natasha L; Palmer, Nicholette D; Rao, Varun; Rauramaa, Rainer; Sun, Quan; Tabara, Yasuharu; Vojinovic, Dina; Wang, Yujie; Weiss, Stefan; Yang, Qian; Zhao, Wei; Zhu, Wanying; Ansari, Md Abu Yusuf; Aschard, Hugues; Anugu, Pramod; Assimes, Themistocles L; Attia, John; Baker, Laura D; Ballantyne, Christie; Bazzano, Lydia; Boerwinkle, Eric; Cade, Brain; Chen, Hung-Hsin; Chen, Wei; Ida Chen, Yii-Der; Chen, Zekai; Cho, Kelly; De Anda-Duran, Ileana; Dimitrov, Latchezar; Do, Anh; Edwards, Todd; Faquih, Tariq; Hingorani, Aroon; Fisher-Hoch, Susan P; Gaziano, J Michael; Gharib, Sina A; Giri, Ayush; Ghanbari, Mohsen; Grabe, Hans Jörgen; Graff, Mariaelisa; Charles Gu, C; He, Jiang; Heikkinen, Sami; Hixson, James; Ho, Yuk-Lam; Hood, Michelle M; Houghton, Serena C; Karvonen-Gutierrez, Carrie A; Kawaguchi, Takahisa; Kilpeläinen, Tuomas O; Komulainen, Pirjo; Lin, Henry J; Linchangco, Gregorio V; Luik, Annemarie I; Ma, Jintao; Meigs, James B; McCormick, Joseph B; Menni, Cristina; Nolte, Ilja M; Norris, Jill M; Petty, Lauren E; Polikowsky, Hannah G; Raffield, Laura M; Rich, Stephen S; Riha, Renata L; Russ, Thomas C; Ruiz-Narvaez, Edward A; Sitlani, Colleen M; Smith, Jennifer A; Snieder, Harold; Sofer, Tamar; Shen, Botong; Tang, Jingxian; Taylor, Kent D; Teder-Laving, Maris; Triatin, Rima; Tsai, Michael Y; Völzke, Henry; Westerman, Kenneth E; Xia, Rui; Yao, Jie; Young, Kristin L; Zhang, Ruiyuan; Zonderman, Alan B; Zhu, Xiaofeng; Below, Jennifer E; Cox, Simon R; Evans, Michelle; Fornage, Myriam; Fox, Ervin R; Franceschini, Nora; Harlow, Sioban D; Holliday, Elizabeth; Ikram, M Arfan; Kelly, Tanika; Lakka, Timo A; Lawlor, Deborah A; Li, Changwei; Liu, Ching-Ti; Mägi, Reedik; Manning, Alisa K; Matsuda, Fumihiko; Morrison, Alanna C; Nauck, Matthias; North, Kari E; Penninx, Brenda Wjh; Province, Michael A; Psaty, Bruce M; Rotter, Jerome I; Spector, Tim D; Wagenknecht, Lynne E; van Dijk, Ko Willems; Jaquish, Cashell E; Wilson, Peter Wf; Peyser, Patricia A; Munroe, Patricia B; de Vries, Paul S; Gauderman, W James; Sun, Yan V; Chen, Han; Miller, Clint L; Winkler, Thomas W; Rao, Dabeeru C; Redline, Susan; van Heemst, Diana |
| Contributors: |
R. Noordam; W. Wang; P. Nagarajan; H. Wang; M.R. Brown; A.R. Bentley; Q. Hui; A.T. Kraja; J.L. Morrison; J.R. O'Connel; S. Lee; K. Schwander; T.M. Bartz; L. De Las Fuente; M.F. Feitosa; X. Guo; X. Hanfei; S.E. Harri; Z. Huang; M. Kal; C. Lefevre; M. Mangino; Y. Milaneschi; P.J. Van Der Most; N.L. Pacheco; N.D. Palmer; V. Rao; R. Rauramaa; Q. Sun; Y. Tabara; D. Vojinovic; Y. Wang; S. Wei; Q. Yang; W. Zhao; W. Zhu; M.A.Y. Ansari; H. Aschard; P. Anugu; T.L. Assime; J. Attia; L.D. Baker; C. Ballantyne; L. Bazzano; E. Boerwinkle; B. Cade; H. Chen; W. Chen; Y. Ida Chen; Z. Chen; K. Cho; I. De Anda-Duran; L. Dimitrov; A. Do; T. Edward; T. Faquih; A. Hingorani; S.P. Fisher-Hoch; J.M. Gaziano; S.A. Gharib; A. Giri; M. Ghanbari; H.J. Grabe; M. Graff; C. Charles Gu; J. He; S. Heikkinen; J. Hixson; Y. Ho; M.M. Hood; S.C. Houghton; C.A. Karvonen-Gutierrez; T. Kawaguchi; T.O. Kilpeläinen; P. Komulainen; H.J. Lin; G.V. Linchangco; A.I. Luik; J. Ma; J.B. Meig; J.B. Mccormick; C. Menni; I.M. Nolte; J.M. Norri; L.E. Petty; H.G. Polikowsky; L.M. Raffield; S.S. Rich; R.L. Riha; T.C. Ru; E.A. Ruiz-Narvaez; C.M. Sitlani; J.A. Smith; H. Snieder; T. Sofer; B. Shen; J. Tang; K.D. Taylor; M. Teder-Laving; R. Triatin |
| Publisher Information: |
Elsevier Ireland Ltd |
| Publication Year: |
2026 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
Settore MEDS-01/A - Genetica medica |
| Description: |
Background and aims Deviations from the population mean in sleep duration have been associated with increased risk for developing dyslipidemia and atherosclerotic cardiovascular disease, but the mechanism of effect is poorly characterized. We performed large-scale genome-wide gene-sleep interaction analyses of lipid levels to identify genetic variants underpinning the biomolecular pathways of sleep-associated lipid disturbances and to suggest possible druggable targets. Methods We collected data from 55 cohorts with a combined sample size of 732,564 participants (87 % European ancestry) with data on lipid traits (high-density lipoprotein [HDL-c] and low-density lipoprotein [LDL-c] cholesterol and triglycerides [TG]). Short (STST) and long (LTST) total sleep time were defined by the extreme 20 % of the age- and sex-standardized values within each cohort. Based on cohort-level summary statistics data, we performed meta-analyses for one-degree of freedom tests of interaction and two-degree of freedom joint tests of the SNP-main and -interaction effect on lipid levels. Results The one-degree of freedom variant-sleep interaction test identified 10 novel loci (Pint |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41325697; volume:412; firstpage:1; lastpage:13; numberofpages:13; journal:ATHEROSCLEROSIS; https://hdl.handle.net/2434/1211820 |
| DOI: |
10.1016/j.atherosclerosis.2025.120603 |
| Availability: |
https://hdl.handle.net/2434/1211820; https://doi.org/10.1016/j.atherosclerosis.2025.120603 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.FF3B87C3 |
| Database: |
BASE |