| Title: |
Comprehensive vs. standard remote monitoring of cardiac resynchronization devices in heart failure patients: results of the ECOST-CRT study |
| Authors: |
Klein, Cédric; Kouakam, Claude; Lazarus, Arnaud; de Groote, Pascal; Bauters, Christophe; Marijon, Eloi; Mouquet, Frédéric; Degand, Bruno; Guyomar, Yves; Mansourati, Jacques; Leclercq, Christophe; Guédon-Moreau, Laurence; Guedon-Moreau, Laurence; Babuty, Dominique; Pons, Maxime; Guy-Moyat, Benoit; Deharo, Jean-Claude; Gras, Daniel; Himbert, Caroline; Pasquie, Jean-Luc; Eschalier, Romain; Marzak, Halim; Boursier, Michel; Jourda, François; Anselme, Frédéric; Gorka, Hervé; Billon, Olivier; Champ-Rigot, Laure; Ait Said, Mina; Taieb, Jérôme; Badoz, Marc; Laborderie, Julien; Belhameche, Mohamed; Ploux, Sylvain; de Guillebon, Maxime; Dompnier, Antoine; Boveda, Serge; Gomes-Ferreira, Sophie; Giraudeau, Cédric; Peyrol, Michael; Winum, Pierre; Gal, Benjamin; Blangy, Hugues; Le Vavasseur, Olivier; Duparc, Alexandre; Forelle, Laura; Behaghel, Albin; Fouche, Renaud; Laurent, Gabriel; Barake, Hassan; Reuter, Sylvain; Sultan, Pierre; da Costa, Antoine |
| Contributors: |
Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Pole Cardio-vasculaire et pulmonaire CHU Lille; Institut Jean Le Rond d'Alembert (DALEMBERT); Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS); Institut Pasteur de Lille; Pasteur Network (Réseau International des Instituts Pasteur); Biologie Structurale Intégrative (ERL 9002 - INSERM U1167 - BSI); Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS); Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE); Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille); Hôpital Européen Georges Pompidou APHP (HEGP); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO); Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); Service de cardiologie CHU de Poitiers; Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ); Hôpital Saint Philibert Lomme; Groupement des Hôpitaux de l'Institut Catholique de Lille (GHICL); Université catholique de Lille (UCL)-Université catholique de Lille (UCL); Centre Hospitalier Régional Universitaire de Brest (CHRU Brest); Optimisation des régulations physiologiques (ORPHY (EA 4324)); Université de Brest (UBO EPE)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Institut Brestois Santé Agro Matière (IBSAM); Université de Brest (UBO EPE)-Université de Brest (UBO EPE); Service de cardiologie et maladies vasculaires Rennes = Cardiac, Thoracic, and Vascular Surgery Rennes; Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou; Laboratoire Traitement du Signal et de l'Image (LTSI); Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM); Institut Coeur Poumon CHU Lille; Centre Hospitalier Régional Universitaire de Tours (CHRU Tours); Université de Tours (UT); Service de cardiologie CHU Limoges; CHU Limoges; Hôpital de la Timone CHU - APHM (TIMONE); Aix Marseille Université (AMU); This work was supported by an unrestricted grant from Biotronik SE & Co. KG. The authors thank the clinical team of BIOTRONIK France SAS and Ms Aramatoulaye Sambou, Research Coordinator in CHU Lille, for their assistance in the conduct of the ECOST-CRT study. |
| Source: |
ISSN: 1099-5129. |
| Publisher Information: |
CCSD; Oxford University Press (OUP) |
| Publication Year: |
2025 |
| Collection: |
Université François-Rabelais de Tours: HAL |
| Subject Terms: |
Cardiac resynchronization therapy; Heart failure; Remote monitoring; [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system |
| Description: |
International audience ; Aims: Integrating remote monitoring (RM) into existing healthcare practice for heart failure (HF) patients to improve clinical outcome remains challenging. The ECOST-CRT study compared the clinical outcome of a comprehensive RM scheme including a patient questionnaire capturing signs and symptoms of HF and notifications for HF specific parameters to traditional RM in patients with cardiac resynchronization therapy (CRT) devices.Methods and results: Patients were randomized 1:1 to standard daily RM (notification for technical parameters and ventricular arrhythmias; control group) or comprehensive RM (adding a monthly symptom questionnaire and notifications for biventricular pacing, premature ventricular contraction, atrial arrhythmias; active group). The primary endpoint was all-cause mortality or hospitalization for worsening HF (WHF). Six hundred fifty-two patients (70.4 ± 10.3 years, 73% men, left ventricular ejection fraction 29.1 ± 7.6%, 68% CRT-Defibrillators, 32% CRT-Pacemakers) were enrolled. The COVID-19 pandemic caused an early termination of the study, so the mean follow-up duration was 18 ± 8 months. No statistically significant difference in the primary endpoint was found between the groups [59 (18.3%) control vs. 77 (23.3%) active group; log-rank test P = 0.13]. Among the secondary endpoints, the MLHF questionnaire showed a larger share of patients with improvement of quality of life compared to baseline in the active group (78%) vs. control (61%; P = 0.03).Conclusion: The study does not support the notion that comprehensive RM, when compared to standard RM, in HF patients with CRT improves the clinical outcome of all-cause mortality or WHF hospitalizations. However, this study was underpowered due to an early termination and further trials are required.Registration: Clinical Trials.gov Identifier: NCT03012490. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39400005; PUBMED: 39400005 |
| DOI: |
10.1093/europace/euae233 |
| Availability: |
https://hal.univ-brest.fr/hal-04905237; https://hal.univ-brest.fr/hal-04905237v1/document; https://hal.univ-brest.fr/hal-04905237v1/file/euae233.pdf; https://doi.org/10.1093/europace/euae233 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.FF4D4B77 |
| Database: |
BASE |