| Title: |
Urotensin receptor in GtoPdb v.2023.1 |
| Authors: |
Davenport, Anthony P.; Douglas, Stephen A.; Fournier, Alain; Giaid, Adel; Krum, Henry; Lambert, David G.; Leprince, Jérôme; MacLean, Margaret R.; Ohlstein, Eliot H.; Thomas, Walter G.; Tostivint, Hervé; Vaudry, David; Vaudry, Hubert; Webb, David J. |
| Source: |
IUPHAR/BPS Guide to Pharmacology CITE; Vol. 2023 No. 1 (2023) ; 2633-1020 |
| Publisher Information: |
University of Edinburgh |
| Publication Year: |
2023 |
| Subject Terms: |
GtoPdb_general: generated Tue May 2 16:06:30 2023; family F65; Urotensin receptor; version 2023.1; GtoPdb_hierarchy: ( F65 O365 I65 ); GtoPdb_authors: 71 348 349 350 352 353 474 560 564 565 566 567 568 569; GtoPdb_references: 6120 7022 7031 7032 7033 7034 7035 7036 7037 7038 7039 7040 7041 7042 7043 7044 7045 7046 7047 7048 7049 7050 7051 7052 7053 7054 7055 7056 7057 7058 7059 7060 7061 7062 7063 7064 7065 7066 7067 7068 7069 7070 7071 7072 7073 7074 7075 7076 7077 7078 7079 7080 7081 7082 7083 7084 7085 7086 7087 7088 7089 7090 7091 7092 7093 7094 7095 7096 7097 7098 7099 7100 7101 7102 7103 7104 7105 14393 14394 14395 14440 14697 14698 14700 14701 15138 18779 28142 30013 32056 32104 32105 32106 32108 32109 39416 41491 41492 42159 44757 |
| Description: |
The urotensin-II (U-II) receptor (UT, nomenclature as agreed by the NC-IUPHAR Subcommittee on the Urotensin receptor [26, 36, 94]) is activated by the endogenous dodecapeptide urotensin-II, originally isolated from the urophysis, the endocrine organ of the caudal neurosecretory system of teleost fish [7, 93]. Several structural forms of U-II exist in fish and amphibians [94]. The goby orthologue was used to identify U-II as the cognate ligand for the predicted receptor encoded by the rat gene gpr14 [2, 20, 63, 69, 72]. Human urotensin-II, an 11-amino-acid peptide [20], retains the cyclohexapeptide sequence of goby U-II that is thought to be important in ligand binding [61, 53, 10]. This sequence is also conserved in the deduced amino-acid sequence of rat urotensin-II (14 amino-acids) and mouse urotensin-II (14 amino-acids), although the N-terminal is more divergent from the human sequence [19]. A second endogenous ligand for the UT has been discovered in rat [86]. This is the urotensin II-related peptide, an octapeptide that is derived from a different gene, but shares the C-terminal sequence (CFWKYCV) common to U-II from other species. Identical sequences to rat urotensin II-related peptide are predicted for the mature mouse and human peptides [32]. UT exhibits relatively high sequence identity with somatostatin, opioid and galanin receptors [94]. The urotensinergic system displays an unprecedented repertoire of four or five ancient UT in some vertebrate lineages and five U-II family peptides in teleost fish [91]. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf; text/html |
| Language: |
English |
| Relation: |
https://journals.ed.ac.uk/gtopdb-cite/article/view/8712/11530; https://journals.ed.ac.uk/gtopdb-cite/article/view/8712/11531; https://journals.ed.ac.uk/gtopdb-cite/article/view/8712/11532 |
| DOI: |
10.2218/gtopdb/F65/2023.1 |
| Availability: |
https://journals.ed.ac.uk/gtopdb-cite/article/view/8712; https://doi.org/10.2218/gtopdb/F65/2023.1 |
| Rights: |
Copyright (c) 2023 The authors |
| Accession Number: |
edsbas.FFA7499B |
| Database: |
BASE |