| Title: |
Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30 mg/day versus aspirin 100 mg/day in stroke patients: the prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) study |
| Authors: |
Bousser, M; Amarenco, P; Chamorro, A; Fisher, M; Ford, I; Fox, K; Hennerici, M; Mattle, H; Rothwell, P; Julian, D; Fieschi, G; Fieschi, C; Boysen, G; Pocock, S; Conard, J; Orgogozo, JM; Inzitari, D; Erkinjuntti, T; Pasquier, F; O'Brien, JT; Mas, JL; Gueret, P; Lenzi, GL; Leys, D; Lopez Sendon, JL; Norrving, B; Ferro, J; Thygesen, K; Cowpply Bonny; P; Ameriso, S; Donnan, D; Lang, W; Thijs, V; Fernandes, JG; Stamenova, P; Teal, P; Lavados, P; Lu, C; Poljakovic, Z; Kalita, Z; Kaste, M; Moulin, T; Vemmos, K; Diener, HC; Wong, LK; Nagy, Z; Chopra, JS; McCormack, P; Gensini, GF; Budrys, V; Droste, D; Tan, KS; Benomar, A; Cantu Brito, C; Barber, A; Koudstaal, PJ; Thomassen, L; Czlonkowska, A; Cunha, L; Bajenaru, O; Yakhno, N; Chen, C; Lisy, L; Zvan, B; Bryer, A; Kim, JS; Vivancos, J; Wahlgren, NG; Mattle, HP; Liu, SJ; Poungvarin, N; Hentati, F; Bahar, S; Mischenko, T; Lees, K; Abdel Masih, ME; Barboza, A; Cirio, JJ; Crespo, E; Escaray, GE; Esnaola, MM; Rojas Estol, C; Ferrari, J; Fraiman, HD; Garrote, M; Gatto, E; Giannaula, RJ; Gori, H; Herrera, G; Ioli, P; Losano, JC; Povedano Reich, E; Rey, RC; Rotta Escalante, R; Saredo, G; Zurru, MC; Anderson, C; Bladin, C; Crimmins, D; Davis, S; Donnan, G; Dunbabin, D; Frayne, J; Gates, P; Hankey, G; Helme, R; Herkes, G; Karrasch, J; Kimber, T; Jannes, J; Landau, P; Levi, C; Lueck, C; Markus, R; Phan, T; Schwartz, R; Schultz, D; Blacker, D; Read, S; Williams, M; Aichner, F; Auff, E; Bancher, C; Binder, H; Brainin, M; Brucke, T; Eggers, C; Fertl, E; Ladurner, G; Lalouschek, W; Mamoli, B; Mitrovic, N; Noisternig, G; Schmidt, R; Vosko, M; Willeit, J; Zaruba, E; Boon, P; Bourgeois, P; Caekebeke, J; Cals, N; Cras, P; Desfontaines, P; De Deyn, PP; Dieudonne, L; De Klippel, N; Laloux, P; Maertens de Noordhout, A; Merlevede, K; Michotte, A; Pandolfo, M; Peeters, A; Peeters, D; Tack, P; Van Buggenhout, E; Van Landegem, W; Vanhooren, G; Vermylen, P; Annes, M; Brondani, R; De Carvalho, JJ; Cendes, F; Fabio, SR; Ferraz, AC; De Freitas, GR; Gagliardi, RJ; Gomes Neto, A; Haussen, SR; Kowacs, PA; Martins, SC; Minelli, C; Moro, CH; Noujaim, JE; Rocha, MS; Da Silva, MT; Silveira, JR; Yamamoto, F; Zetola, VH; Baldaranov, D; Deleva, N; Haralanov, L; Milanov, I; Mintchev, D; Petrova, N; Shotekov, P; Stamenov, B; Zahariev, Z; Arts, R; Bayer, N; Beaudry, M; Berger, L; Bozek, C; Collier, T; Cote, R; Desai, H; Durocher, A; Hachinski, V; Hill, M; Hoppe, B; Howse, D; Mackey, A; Maharaj, M; Minuk, J; Moddel, G; Novak, D; Penn, A; Rabinovitch, H; Selchen, D; Shuaib, A; Silva, J; Silver, F; Spence, D; Stotts, G; Tamayo, A; Teitelbaum, J; Veloso, F; Voll, C; Winder, T; Barrientos Uribe, N; Galdames Poblete, D; Garcia Figueroa, P; Gasic Yaconi, K; Jaramillo Munoz, A; Lavados Germain, P; Lavados Montes, M; Nancupil Bello, CR; Prina Pacheco, L; Vargas Canas, A; Venegas Francke; P: Chen; H; Cheng, Y; Cui, L; Di, Q; Dong, Q; Fan, D; Feng, H; Huang, Y; Li, J; Li, W; Li, Z; Lin, H; Liu, M; Miao, L; Ren, H; Wang, Y; Wu, J; Zhang, W; Zhao, G; Zhao, H; Zhou, H; Antoncic, I; Demarin, V; Lusic, I; Pavlicek, I; Soldo Butkovic, S; Bar, M; Bauer, J; Kalina, M; Kanovsky, P; Jura, R; Neumann, J; Rektor, I; Skoda, O; Vaclavik, D; Eerola, A; Hillbom, M; Kinnunen, E; Koivisto, K; Numminen, H; Rissanen, A; Roine, R; Sivenius, J; Alamowitch, S; Autret, A; Avendano, S; Bataillard, M; Berthier, E; Besson, G; Bille Turc, F; Boulliat, J; Boulesteix, JM; Brosset, C; Cesaro, P; Albucher, JF; Clavelou, P; Colamarino, R; Crassard, I; de Broucker, T; de Bray, JM; Desbordes, P; Diot, E; Ducrocq, X; Ellie, E; Faucheux, JM; Giroud, M; Godefroy, O; Guillon, B; Huttin, H; Just, A; Lamy, C; Lejeune, P; Lucas, C; Macian Montoro, F; Mackowiak, A; Maillet Vioud, M; Pico, F; Milandre, L; Milhaud, D; Malbec, M; Neau, JP; Pinel, JF; Robin, C; Rodier, G; Rosolacci, T; Rouanet, F; Rouhart, FF; Sablot, D; Servan, J; Smadja, D; Trouillas, P; Valance, J; Viader, F; Viallet F; Wolff V; Zagnoli F; Zuber M; Angerer M; Becker U; Berlit P; Berrouschot J; Biniek, R; Bitsch, A; Brodhun, R; Dichgans, M; Druschky, KF; Dux, R; Faiss, JH; Ferbert, A; Gahn, G; Grotemeyer, KH; Goertler, M; Grau, A; Griewing, B; Grond, M; Haan, J; Haberl, R; Hamann, G; Hamer, H; Harms, L; Heide, W; Henningsen, H; Hetzel, A; Hoffmann, F; Huber, R; Isenmann, S; Jander, S; Joerg, J; Kaps, M; Kastrup, A; Kessler, C; Koehler, W; Koelmel, HW; Lichy, C; Luckner, K; Malessa, R; Mallmann, A; Meyding Lamade, U; Molitor, H; Mueller Jensen, A; Muellges, W; Noth, J; Nueckel, M; Ochs, G; Poppert, H; Roether, J; Rosenkranz, M; Sander, D; Schaebitz, WR; Schlachetzki, F; Schlegel, U; Schmid, E; Schneider, D; Schwarz, M; Seidel, G; Sieble, M; Sliwka, U; Stingele, R; Stoegbauer, F; Szabo, K; Topper, R; Treib, J; Weissenborn, K; Widder, B; Witte, O; Karageorgiou, K; Mitsikostas, DD; Papadimitriou, A; Papathanasopoulos, P; Chan, H; Ng, P; Tsoi, T; Bartos, L; Csanyi, A; Csiba, L; Csornai, M; Dioszeghy, P; Fazekas, A; Harcos, P; Horvath, S; Kaposzta, Z; Kerenyi, L; Kincses, J; Koves, A; Nikl, J; Panczel, G; Pongracz, E; Sebestyen, K; Semjen, J; Szabo, M; Szegedi, N; Valikovics, A; Varszegi, R; Vecsei, L; Borah, N; Ichaporia, N; Kaul, S; Meenakshi Sundaram, S; Mehndiratta, MM; Misra, UK; Murthy, JM; Nayak, D; Poncha, F; Shah, A; Singh, G; Srinivasa, R; Venkateswarlu, K; Wadia, RS; Collins, R; Harbison, J; Hickey, P; Kelly, P; Murphy, S; Adami, A; Agnelli, G; Agostoni, E; Anzola, GP; Arnaboldi, M; Bassi, P; Billo, G; Bottacchi, E; Bovi, P; Cappa, S; Cappelletti, C; Carolei, A; Cavallini, A; Chiodo Grandi, F; Comi, G; Consoli, D; Corsi, FM; Costanzo, E; De Falco, F; Devetag, F; Di Lazzaro, V; Di Piero, V; Fattorello Salimbeni, C; Federico, F; Feleppa, M; Ferrarese, C; Gandolfo, C; Giaccaglini, E; Giaquinto, S; Giobbe, D; Giometto, B; Greco, G; Guidetti, D; Guidotti, M; Iudice, A; Lembo, G; Marengo, C; Marini, P; Melis, M; Micieli, G; Musolino, R; Mutani R; Neri G; Parati E; Pastore L; Porazzi D; Prati P; Procaccianti G; Rasura M; Rossini, PM; Santilli ,IM; Semplicini, A; Silvestrini, M; Tanganelli, P; Tedeschi, G; Tezzon, F; Tola, MR; Villani, A; Zanferrari, C; Zarcone, D; Bickuviene, I; Gumbrevicius, G; Obelieniene, D; Skaringa, AA; Virketiene, I; Tharakan, J; Aleman Pedroza, JM; Escamilla Garza, JM; Fernandez Vera, JA; Leal Cantu, R; Leon Flores, LI; Lopez Ruiz, M; Reyes Gutierrez, GA; Reyes Morales, S; Rivera Castano, L; Rodrigues Leyva, I; Ruiz Sandoval, JL; Vega Boada, F; Belahsen, F; Kissani, N; Mosseddaq, R; Slassi, I; Yahyaoui, M; Boiten, J; Bornebroek, M; De Kort, PL; De Leeuw, HF; Donders, RC; Franke, CL; Hertzberger, LI; Jansen, BP; Kappelle, LJ; Keizer, K; Kuster, JA; Limburg, M; Mulleners, WM; Pop, PH; Van Den Berg, JS; Van Gemert, HM; Verbiest, HB; Weinstein, HC; Clark, M; Fink, J; Gommans, J; Jayathissa, S; Kilfoyle, D; Kumar, A; Hurtig, U; Indredavik, B; Kloster, R; Salvesen, R; Drozdowski, W; Fryze, W; Klimek, A; Kochanowski, J; Kozubski, W; Ksiazkiewicz, B; Kwiecinski, H; Kuczynska Zardzewialy, A; Motta, E; Nowacki, P; Nyka, W; Opala, G; Pierzchala, K; Pniewski, J; Podemski, R; Selmaj, K; Stelmasiak, Z; Stepien, A; Strzelecka Gorzynska, M; Szczudlik, A; Wajgt, A; Wiszniewska, M; Wlodek, A; Canhao, P; Correia, C; Grilo Goncalves, J; Machado Candido, J; Salgado, AV; Bulboaca, A; Campeanu, A; Lazar, T; Marginean, I; Minea, D; Pascu, I; Pereanu, M; Perju Dumbrava, L; Popescu, CD; Simu, M; Stefanache, F; Toldisan, I; Tuta, S; Zaharia, C; Alifirova, V; Arkhipov, S; Balunov, O; Balyazin, V; Belkin, A; Belova, A; Boiko, A; Bogdanov, E; Butko, D; Chukhlovina, M; Doronin, B; Ermilova, E; Evzelman, M; Fedin, A; Fedorova, N; Golikov, K; Golovkin, V; Gusev, E; Gustov, A; Jakupov, E; Kamchatnov, P; Khabirov, F; Kirienko, A; Klimov, I; Klocheva, E; Kotov, S; Kuznetsov, A; Laskov, V; Levin, Y; Mashkova, N; Nazarov, A; Novikova, L; Odinak, M; Parfenov, V; Pilipenko, P; Pokrovsky, A; Poverennova, I; Rodoman, G; Roshkovskaya, L; Shirokov, E; Shmyriov, V; Sholomov, I; Skoromets, A; Skvortsova, V; Spirin, N; Stakhovskaya, L; Sharov, M; Sherman, M; Shutov, A; Strachunskaya, E; Stulin, I; Suslina, Z; Volosevitch, A; Vorobiev, P; Vorobyeva, O; Voronkova, L; Voskresenskaya, O; Zhuliov, N; Chan, B; Chang, HM; Ramani, NV; Brozman, M; Dvorak, M; Dzugan, J; Garay, R; Gdovinova, Z; Gurcik, L; Krastev, G; Kukumberg, P; Kurca, E; Meluch, S; Nyeky, M; Turcani, P; Vyletelka, J; Klanjscek, G; Zujovic, E; Zupan, M; Bester, FC; Carr, J; Coetzee, C; Frost AC; Gardiner J; Giampaolo DL; Kesler S; Lurie DM; Retief CF; Roos JS; Bae HJ; Cha JK; Cho KH; Heo JH; Kim EG; Kim JS; Lee BC; Lee KH; Lee J; Rha JH; Yoon BW; Alvarez Sabin J; Arboix Damunt A; De Arce Borda A; Asensi Alvarez JM; Bermejo Pareja F; Botia Paniagua E; Casado I; Naranjo I; Castillo Sanchez J; Chamorro Sanchez A; Davalos Errando A; Diaz Marin C; Diez Tejedor E; Egido Herrero JA; Fernandez Bolanos R; Fernandez Fernandez O; Figuerola Roig A; Geffner Sclarsky D; Gil Nunez A; Gomez Sanchez JC; Gomez Escalonilla Escobar CI; Gonzalez Masegosa A; Gonzalez Menacho J; Gracia Fleta F; Izquierdo Ayuso G; Jimenez Hernandez D; Jimenez Martinez C; Lago Martin A; 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| Contributors: |
Bousser, M; Amarenco, P; Chamorro, A; Fisher, M; Ford, I; Fox, K; Hennerici, M; Mattle, H; Rothwell, P; Julian, D; Fieschi, G; Fieschi, C; Boysen, G; Pocock, S; Conard, J; Orgogozo, J; Inzitari, D; Erkinjuntti, T; Pasquier, F; O'Brien, J; Mas, J; Gueret, P; Lenzi, G; Leys, D; Lopez Sendon, J; Norrving, B; Ferro, J; Thygesen, K; Cowpply, B; P; Ameriso, S; Donnan, D; Lang, W; Thijs, V; Fernandes, J; Stamenova, P; Teal, P; Lavados, P; Lu, C; Poljakovic, Z; Kalita, Z; Kaste, M; Moulin, T; Vemmos, K; Diener, H; Wong, L; Nagy, Z; Chopra, J; Mccormack, P; Gensini, G; Budrys, V; Droste, D; Tan, K; Benomar, A; Cantu Brito, C; Barber, A; Koudstaal, P; Thomassen, L; Czlonkowska, A; Cunha, L; Bajenaru, O; Yakhno, N; Chen, C; Lisy, L; Zvan, B; Bryer, A; Kim, J; Vivancos, J; Wahlgren, N; Liu, S; Poungvarin, N; Hentati, F; Bahar, S; Mischenko, T; Lees, K; Abdel Masih, M; Barboza, A; Cirio, J; Crespo, E; Escaray, G; Esnaola, M; Rojas Estol, C; Ferrari, J; Fraiman, H; Garrote, M; Gatto, E; Giannaula, R; Gori, H; Herrera, G; Ioli, P; Losano, J; Povedano Reich, E; Rey, R |
| Publisher Information: |
S Karger AG |
| Publication Year: |
2009 |
| Collection: |
Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| Subject Terms: |
Ischemic Attack; Transient; Double-Blind Method; Endpoint Determination; Dose-Response Relationship; Drug; Human; Stroke; Receptors; Thromboxane; Aged; Propionate; Naphthalene; Aspirin; International Cooperation; 80 and over; Treatment Outcome; Platelet Aggregation Inhibitor; Cardiovascular Disease; Middle Aged; Female; Male; Settore MED/26 - NEUROLOGIA |
| Description: |
Ischemic stroke is the leading cause of mortality worldwide and a major contributor to neurological disability and dementia. Terutroban is a specific TP receptor antagonist with antithrombotic, antivasoconstrictive, and antiatherosclerotic properties, which may be of interest for the secondary prevention of ischemic stroke. This article describes the rationale and design of the Prevention of cerebrovascular and cardiovascular Events of ischemic origin with teRutroban in patients with a history oF ischemic strOke or tRansient ischeMic Attack (PERFORM) Study, which aims to demonstrate the superiority of the efficacy of terutroban versus aspirin in secondary prevention of cerebrovascular and cardiovascular events. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:000265417600013; volume:27; issue:5; firstpage:509; lastpage:518; journal:CEREBROVASCULAR DISEASES; https://hdl.handle.net/2108/83387 |
| DOI: |
10.1159/000212671 |
| Availability: |
https://hdl.handle.net/2108/83387; https://doi.org/10.1159/000212671 |
| Accession Number: |
edsbas.FFCAEE57 |
| Database: |
BASE |