| Title: |
Cost-effectiveness of topical pharmacological, oral pharmacological, physical and combined treatments for acne vulgaris |
| Authors: |
Mavranezouli, Ifigeneia; Welton, Nicky J.; Daly, Caitlin H.; Wilcock, Jane; Bromham, Nathan; Berg, Laura; Xu, Jingyuan; Wood, Damien; Ravenscroft, Jane C.; Dworzynski, Katharina; Healy, Eugene |
| Publication Year: |
2022 |
| Collection: |
University of Southampton: e-Prints Soton |
| Description: |
Background. Acne vulgaris is a common skin condition that may cause psychoso-cial distress. There is evidence that topical treatment combinations, chemical peels and photochemical therapy (combined blue/red light) are effective for mild-to-moderate acne, while topical treatment combinations, oral antibiotics combined with topical treatments, oral isotretinoin and photodynamic therapy are most effective for moderate-to-severe acne. Effective treatments have varying costs. The National Institute for Health and Care Excellence (NICE) in England considers cost-effectiveness when producing national clinical, public health and social care guidance. Aim: To assess the cost-effectiveness of treatments for mild-to-moderate and moderate-to-severe acne to inform relevant NICE guidance. Methods: A decision–analytical model compared costs and quality-adjusted life-years (QALYs) of effective topical pharmacological, oral pharmacological, physical and combined treatments for mild-to-moderate and moderate-to-severe acne, from the perspective of the National Health Service in England. Effectiveness data were derived from a network meta-analysis. Other model input parameters were based on published sources, supplemented by expert opinion. Results: All of the assessed treatments were more cost-effective than treatment with placebo (general practitioner visits without active treatment). For mild-to-moderate acne, topical treatment combinations and photochemical therapy (com-bined blue/red light) were most cost-effective. For moderate-to-severe acne, topical treatment combinations, oral antibiotics combined with topical treatments, and oral isotretinoin were the most cost-effective. Results showed uncertainty, as reflected in the wide confidence intervals around mean treatment rankings. Conclusion: A range of treatments are cost-effective for the management of acne. Well-conducted studies are needed to examine the long-term clinical efficacy and cost-effectiveness of the full range of acne treatments. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://eprints.soton.ac.uk/472985/1/Clin_Experimental_Derm_2022_Mavranezouli_Cost_effectiveness_of_topical_pharmacological_oral_pharmacological_.pdf; Mavranezouli, Ifigeneia, Welton, Nicky J., Daly, Caitlin H., Wilcock, Jane, Bromham, Nathan, Berg, Laura, Xu, Jingyuan, Wood, Damien, Ravenscroft, Jane C., Dworzynski, Katharina and Healy, Eugene (2022) Cost-effectiveness of topical pharmacological, oral pharmacological, physical and combined treatments for acne vulgaris. Clinical and Experimental Dermatology, 47 (12), 2176–2187. (doi:10.1111/ced.15356 ). |
| Availability: |
https://eprints.soton.ac.uk/472985/; https://eprints.soton.ac.uk/472985/1/Clin_Experimental_Derm_2022_Mavranezouli_Cost_effectiveness_of_topical_pharmacological_oral_pharmacological_.pdf |
| Rights: |
cc_by_nc_4 |
| Accession Number: |
edsbas.FFE586CF |
| Database: |
BASE |