| Title: |
Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies |
| Authors: |
Dorajoo, R; Chang, X; Gurung, RL; Li, Z; Wang, L; Wang, R; Beckman, KB; Adams-Haduch, J; M, Y; Liu, S; Meah, WY; Sim, KS; Lim, SC; Friedlander, Y; Liu, J; van Dam, RM; Yuan, JM; Koh, WP; Khor, CC; Heng, CK |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2019 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
Genetic factors underlying leukocyte telomere length (LTL) may provide insights into telomere homeostasis, with direct links to disease susceptibility. Genetic evaluation of 23,096 Singaporean Chinese samples identifies 10 genome-wide loci (P < 5 × 10-8). Several of these contain candidate genes (TINF2, PARP1, TERF1, ATM and POT1) with potential roles in telomere biology and DNA repair mechanisms. Meta-analyses with additional 37,505 European individuals reveals six more genome-wide loci, including associations at MPHOSPH6, NKX2-3 and TYMS. We demonstrate that longer LTL associates with protection against respiratory disease mortality [HR = 0.854(0.804-0.906), P = 1.88 × 10-7] in the Singaporean Chinese samples. We further show that the LTL reducing SNP rs7253490 associates with respiratory infections (P = 7.44 × 10-4) although this effect may not be strongly mediated through LTL. Our data expands on the genetic basis of LTL and may indicate on a potential role of LTL in immune competence. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://hdl.handle.net/11343/277585 |
| Availability: |
https://hdl.handle.net/11343/277585 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.FFEF5F8C |
| Database: |
BASE |